Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five hundred and eighty-eight patients with mitral valve disease were studied. The incidence of systemic emboli was found to be higher in patients with pure mitral stenosis (16.6%) and mixed mitral stenosis and incompetence (19.4%) than in patients with mitral incompetence (3.1%). The patients with mitral stenosis who had episodes of systemic emboli tended to be older than 40 years, with moderate or severe valve lesions, atrial fibrillation and moderate or gross enlargement of the left atrial appendage or left atrium. The following factors were found to be unrelated to systemic embolism---associated aortic valve disease, sex, smoking habit, history of rheumatism, parity, haemoglobin, blood urea, pulmonary hypertension, duration of antifailure treatment, presence of heart failure, and cardiothoracic ratio.
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PMID:Thromboembolic complications of mitral valve disease. 28 50

Trichinellosis myocarditis with the presence of juvenile forms of the parasite in the myocardium is an extremely rare pathology, according to the literature. The present observation refers to a woman of 43 who had been treated for a long time for rheumatism. In 1974, aortic valve failure was diagnosed and in September, 1976, she was sent for operative treatment. Three hours after admission she developed acute cardiac insufficiency and died. Trichinellosis myocarditis was diagnosed at autopsy.
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PMID:[Trichinosis-induced myocarditis]. 73 13

Physical performance of children with rheumatic heart diseases depends upon the activity of rheumatism (rheumatism carditis) and specificity distinguishing the given disease. Spiroergometric examinations under a load of 1 w/kg is a highly informative method of evaluating the physical performance capacity of children with rheumatic heart diseases. By using this method it is possible to obtain quantitative and qualitative functional characteristics of their cardiopulmonary system, to disclose latent cardiac insufficiency. The data obtained help improve the rehabilitation of rheumatic patients.
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PMID:[Physical work capacity in rheumatic heart defects in children]. 102 17

In 56 patients aged over 60 years features peculiar to the diagnosis and the course of rheumatic heart diseases were studied. Clinical and laboratory findings, those of roentgenoscopy and roentgenography of the heart, as well as of electro- and phonocardiography were used. In 35 lethal cases clinico-anatomic comparisons and histological investigation were made for elucidating the activity of the rheumatic process. In persons aged over 60 the relapses of rheumatism have been found to be of rare occurrence and rheumatic affections run a course without any marked hypertension in the lesser circulation and become complicated by cardiac insufficiency no sooner than many years after establishiment fo the diagnosis. In individuals older than 60 an active rheumatic process according to histological investigations and the authors occurs in 14.3 per cent of the cases.
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PMID:[Characteristics of diagnosis and clinical course of rheumatic heart defects in middle- and old age]. 102 34

Idiopathic inflammatory myopathy, a category encompassing polymyositis, dermatomyositis, and a number of other disorders, is very uncommon, but has been the focus of intense study in the Arthritis and Rheumatism Branch of the National Institute of Arthritis and Musculoskeletal and Skin Diseases for the past several years. We describe the clinical picture, stressing the need for biopsy to ensure correct diagnosis. It is especially important to recognize the treatment-resistant variant, inclusion body myositis. The extraskeletal manifestations, particularly the cardiopulmonary, oropharyngeal, gastrointestinal, and endocrine involvement, are described. The cardiopulmonary involvement, especially interstitial lung disease, arrhythmias, and cardiac failure, may dominate the clinical picture. The known causes are varied, and include drugs, toxins, and some infectious agents, however, in most cases a cause cannot yet be identified. Circumstantial evidence suggests that picornaviruses may initiate some cases in humans, and a very similar disease in mice caused by a picornavirus is actively under study. Studies of autoantibodies and cellular immune function support a central role for disordered immunity in the pathogenesis. The myositis-specific autoantibodies, especially those directed at certain enzymes important in protein synthesis (the aminoacyl-transfer RNA synthetases), are found in a clinically distinct subset of patients. Although most patients respond initially to corticosteroids, cytotoxic drugs are sometimes added when steroid toxicity or refractoriness develops. We describe several newer therapies under study for such cases and outline future directions in research.
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PMID:Current concepts in the idiopathic inflammatory myopathies: polymyositis, dermatomyositis, and related disorders. 266 48

The authors report 6 cases of severe and silent aortic insufficiency having simulated in all aspects the picture of a dilated cardiomyopathy at the stage of cardiac insufficiency with primary manifestations. They insist on signs leading to the diagnosis of this clinical entity: past history of rheumatism, signs of electrical left ventricular hypertrophy in the absence of arterial hypertension, aortic calcifications and mostly presence of a discrete mitral diastolic fluttering during echocardiographic examination. Supra-sigmoid aortic angiography confirms the diagnosis of severe aortic regurgitation. In order to explain the non-perception of the murmur, they invoke the alteration of the transmission secondary to an air cushion (3 cases the association of another valvulopathy with murmur (1 case) and mainly the decrease of the leakage by increase of the left ventricular telediastolic pressure and the decrease of the diastolic aortic pressure, with diminution of the turbulences. The advantage of knowing this entity rests on the possibility of valve replacement, even at the stage of myocardial failure, since the satisfactory long-term post-operative evolution in 4 patients stands in contrast with the dangerous nature of a spontaneous evolution.
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PMID:[Silent aortic insufficiency mimicking dilated cardiomyopathy]. 359 58

A case of systemic lupus erythematosus (SLE) associated with fever, heart failure, and left ventricular (LV) aneurysm is reported. A diagnosis of SLE was suspected owing to the presence of active lymphocytic myocarditis and fibrinous endocarditis at LV endomyocardial biopsy and was confirmed by identification of 4 of the 11 criteria proposed by the American Rheumatism Association for the definition of SLE. A 2-month period of steroid therapy was followed by a remarkable recovery of LV function and progression of endomyocarditis to a healed phase at control LV biopsy. The LV aneurysm disappeared, likely because thrombosis occurred as a result of the hypercoagulable state accompanying the presence of anticardiolipin antibodies. This is the first reported case of LV aneurysm induced by SLE and is a rare clinicohistologic documentation of the effectiveness of steroid treatment on lupus endomyocarditis.
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PMID:Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus. 854 1

The aim of the investigation was microalbuminuria evaluation as an early symptom of renal involvement in systemic lupus erythematosus (SLE). Thirty patients aged 18 to 66 years (mean: 39,4 years) with mean duration of SLE of 6,3 years (range: 0,5 to 22 years) were examined. All of them fulfilled the preliminary criteria of the American Rheumatism Association for the classification of SLE. During the study none of patients had clinical or laboratory symptoms of nephropathy, hypertension, diabetes mellitus and heart failure. Microalbuminuria was measured by immunoturbidimetric method and the urine microalbumin concentration was expressed as the ratio microalbumin-creatinine concentration in 24 hour urine [equation: see text] Ratio I was 3,36 (+/- 2,76) in patients suffering from SLE comparing to I = 1,35 (+/- 0.89) in normal controls (p < 0.001). There was no correlation between increasing microalbuminuria and patients age and duration of disease. There was also no correlation between microalbuminuria and erythrocyte sedimentation rate or immunological activity parameters (i.e. antinuclear antibodies, anti dsDNA antibodies, levels of C3 and C4 components of complement).
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PMID:[Microalbuminuria in patients with systemic lupus erythematosus]. 912

In 39 patients the correction of insufficiency of mitral, tricuspid and aortic valves were performed by cardiopulmonary bypass. Genesis of valve diseases was rheumatism. Correction of tricuspid valve insufficiency was performed by annuloplasty with one or two hemiarch sutures by N. M. Amosov--De Vega method. Correction of mitral and aortic valve diseases included double valve replacement--in 37 (94.9%) patients, mitral valve replacement and plication of aortic cusp by Trusler's method--in 2 (5.1%). From 39 consecutive operated patients at the hospital period 15 died. The main reason of death was acute heart failure. The late results were followed-up in 21 patients. The good result were marked in 6 (28.6%) patients, satisfactory one--in 6 (28.6%) and unsatisfactory--in 1 (4.8%). 8 (38.1%) patients were died during 1 till 8 years. Correction of combined insufficiency lead to high hospital mortality and there were not good results of survival and good results stability at the late period.
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PMID:[Surgical correction of combined insufficiency of mitral, tricuspid and aortic valves]. 1244 88

Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine.
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PMID:Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb. 2171 18


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