Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 50-year-old female patient with a long history of Raynaud's phenomenon and rapidly deteriorating right-sided cardiac failure is presented. Pulmonary veno-occlusive disease was diagnosed from typical clinical and hemodynamic findings using a Swan-Ganz balloon catheter. The diagnosis was definitely confirmed at necropsy. There was no clinical, laboratory, or histologic evidence of a connective tissue disease.
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PMID:Pulmonary veno-occlusive disease. 295 33

Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension that mainly affects children and young adults. Its cause is unknown, although viral infections and drugs have been implicated. Patients with PVOD present with symptoms of right-sided heart failure. Radiologic examination shows prominent pulmonary arteries with Kerley B lines, pleural effusion, and mediastinal adenopathy. The definite diagnosis is made by histologic examination. Eccentric intimal fibrosis and recanalized thrombi in pulmonary veins and venules, arterialized veins, alveolar edema, and medial hypertrophy of arteries are seen on lung biopsy. No effective treatment is available; lung transplantation has been tried. The prognosis associated with PVOD is poor.
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PMID:Pulmonary veno-occlusive disease. 1046 36