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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Radionuclide study of ejection fraction of the right heart ventricle was carried out in lung tuberculosis patients with respiratory insufficiency and cor pulmonale. Oxygen therapy was found to promote reduction of right ventricle heart failure in effective treatment of lung tuberculosis. The greatest reduction of heart failure was recorded in cases where oxygen therapy was combined with cardiac glycosides. As the tuberculosis process progresses, oxygen therapy does not decrease right ventricle heart failure. The treatment by antibacterial agents alone without using oxygen does not lead to the rise of ejection fraction of the right ventricle of the heart.
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PMID:[Ventricular ejection fraction in oxygen therapy of patients with pulmonary tuberculosis]. 164 45

The purpose of the study was to elaborate criteria for the assessment of the severity of pulmonary hypertension and cor pulmonale in patients with chronic bronchitis and to give rationale for expert medical evaluation of the working capacity of such patients. 94 patients (89 males and 5 females) aged 20 to 60 with chronic bronchitis were examined. Basing on the clinical, x-ray, ECG, VCG and echocardiography data, the gravity of cor pulmonale was assessed by the degree of right ventricular hypertrophy (absent, mild, marked, dramatically marked), changes in the right ventricular echo dimensions and the stage of heart failure, and by the lung vital capacity (in percent of the predicted value). The rationale for expert medical evaluation of patients with associated cor pulmonale and chronic bronchitis is described.
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PMID:[The medical disability evaluation of patients with pulmonary hypertension and cor pulmonale]. 182 62

The association between proteinuria and congestive cardiac failure was investigated in patients with hypertensive heart disease, cardiomyopathy, rheumatic heart disease and cor pulmonale. In 33 such patients, proteinuria occurred before and after successful treatment of the cardiac failure. Overall there was a wide variation in the degree of proteinuria amongst the various groups and statistical analysis showed that the distribution of levels of proteinuria and the mean levels of proteinuria were statistically different between any two groups of patients, P = 0.05. Biopsy proven hypertensive nephrosclerosis was found to be a cause of heavy proteinuria which was in the nephrotic range in two such patients. Congestive cardiac failure due to hypertensive heart disease should be included in the differential diagnosis of massive proteinuria even in the absence of renal insufficiency.
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PMID:The pattern of proteinuria in congestive cardiac failure due to common heart diseases. 206 87

Acute course and long-term regimens of depin-E administration were evaluated clinically and pharmacologically in 50 patients with chronic obstructive bronchitis (COB) and chronic cor pulmonale (CCP). The drug has three mechanisms of action: arteriolovenodilating, bronchodilating, direct pulmonary vascular. Therapeutic effect was achieved in 80% and 60% of COB and CCP patients, respectively. No response was demonstrated for patients with severe cardiac failure. Depin-E can be recommended for prophylaxis and treatment of CCP, to arrest hypertension crises in lesser circulation, to improve pulmonary circulation, central hemodynamics, exercise tolerance.
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PMID:[Effectiveness of depin-E in patients with chronic bronchitis]. 221 46

The effect of digoxin in the treatment of decompensated chronic cor pulmonale was investigated in a randomized double-blind, cross-over, placebo-controlled trial. A total of 34 successive patients with evident right heart failure were included in the study. The mean maintenance daily dose of digoxin was 0.30 +/- 0.03 mg with the mean serum level of 1.7 +/- 0.7 nmol/L. The severity of heart failure was assessed according to a clinicoradiographic scoring system (Heart Failure Score). The heart failure worsened during the placebo-period in eight (23.5%) patients (four with atrial fibrillation, two with a third heart sound (S3), one with a cardiothoracic ratio of more than 0.5 and one with sinus rhythm). By regression analysis, the heart failure significantly worsened only in the subgroup of patients with atrial fibrillation. Digoxin was successfully (without worsening of the heart failure) discontinued in 26 (76.5%) patients. No significant improvement was observed in the patients with S3 gallop. It was concluded that digoxin had no beneficial effect in chronic cor pulmonale patients with heart failure, except in those with atrial fibrillation.
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PMID:Role of digoxin in right ventricular failure due to chronic cor pulmonale. 222 40

Decompensated cor pulmonale is a clinical syndrome manifested by signs of congestive heart failure in pulmonary disease. The authors emphasize that the haemodynamic characteristic of the syndrome differs substantially from the classical picture of chronic heart failure: the cardiac output is usually normal at rest and sometimes even during exercise, signs of impaired contractility of the right ventricle are absent and the effect of cardiac glycosides is minimal. It is possible that the clinical syndrome of decompensated cor pulmonale is caused mainly by respiratory failure and subsequent impaired function of some organs, in particular the kidney.
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PMID:[Cor pulmonale and cor pulmonale decompensation--what is the future of these terms?]. 224 74

Until now the pathomechanism of pulmonary heart disease is insufficiently elucidated. Therefore, at present, rational therapeutical concepts are possible only in chronic obstructive lung diseases. Without any modification, the principle of comprehensive treatment of the basic pulmonary disease remains valid. In the symptomatic therapy of the pulmonary heart disease, in first place the long-term oxygen therapy becomes mandatory. Treatment with vasodilatory drugs remains in the long-term activity disappointing. Reasonable expectations are directed to clinical trials of angiotensin-converting-enzyme-inhibitors. Cardiac glycosides remain reserved for manifest cardiac failure. The stabilization of the acid-base-balance is of great importance for the efficacy of treatment. The decision on the use of additives depends upon a critical evaluation of the actual clinical state and upon the consideration of the risks from polymorbidity.
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PMID:[Therapeutic principles in pulmonary heart disease and right heart insufficiency]. 238 53

Cor pulmonale was diagnosed in a 4-year-old beef cow at pasture. Clinical and pathological evidence for the diagnosis included ventral oedema, respiratory distress, chronic interstitial pneumonia and cardiac failure. The cause of the pneumonia was not identified.
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PMID:Cor pulmonale in an Angus cow. 259 Jan 40

Cardiac arrhythmias (CA) are a frequent and dangerous complication of respiratory and cardiac failure in patients with chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effects of mexiletine on CA in patients with cor pulmonale in a state of cardio-respiratory decompensation. We studied 32 COPD patients with severe airways obstruction; mean VC 2.35 +/- 0.53 litres; FEV1, 0.92 +/- 0.3 litres and respiratory failure, PaO2 = 56 +/- 5 mm Hg, PaCO2 = 47 +/- 9 mm Hg allocated by random numbers to 20 treated and 12 controls. Continuous 24-hour Holter monitoring was performed for 3 consecutive days after admission to the department following routine treatment which consisted of low-flow oxygen, antibiotic, bronchodilators and diuretics. On the first day, the type and frequency of CA were analysed. Then the treated patients were given mexiletine 250 mg i.v. + 200 mg orally followed by 200 mg every 8 h for the next 48 h. Controls continued the routine treatment only. Mexiletine treatment resulted in a highly significant reduction in the mean number of premature ventricular beats from 163 to 28 and 30/24 h, respectively (p less than 0.01). Episodes of ventricular tachycardia were abolished. The mean number of premature supraventricular beats also fell from 85 to 67 and 48/24 h (p less than 0.01). Number of episodes of sinus tachycardia fell from 17 during the first day to 13 and 10 on the 2nd and 3rd days, respectively. In the controls, the frequency and type of CA remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The effects of mexiletine on cardiac arrhythmias in patients with cor pulmonale. 263 53

In this study, observation of the effects of verapamil on pulmonary arterial pressure and on treating right heart failure were done in 15 patients with chronic cor pulmonale complicated with heart failure using monitoring of hemodynamic changes by right cardiac catheter. The results showed that verapamil had remarkable effect on pulmonary arterial pressure. With no significant effect on systemic blood pressure, verapamil decreases right ventricular systolic pressure by 1.3 kPa (9.6 mmHg), pulmonary arterial systolic pressure by 1.5 kPa (11 mmHg) and mean pulmonary arterial pressure by 1.1 kPa (8.5 mmHg). Verapamil is clinically useful by decreasing cardiac afterload, improving cardiac function, treating right heart failure and relieving bronchial spasm.
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PMID:[Effects of verapamil on pulmonary arterial pressure in patients with cor pulmonale complicated by heart failure]. 263 53


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