Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results of early studies support the concept that steroid treatment may reduce mortality from acute myocardial infarction. This double-blind, randomized, 1118-patient study was performed to determine if methylprednisolone sodium succinate (MPSS, Solu-Medrol Sterile Powder, The Upjohn Company) reduced 28-day mortality following myocardial infarction complicated by cardiac failure. Treatment with 30 mg/kg intravenous MPSS (maximum dose, 3 g) resulted in 28-day mortality rates of 11.7% with MPSS and 9.9% with placebo when treatment was initiated within six hours of the onset of chest pain (Group 1). Mortality rates at 28 days were 10.4% with MPSS and 14.7% with placebo when the treatment was initiated 6-12 hours after onset of chest pain (Group 2). In the late-treatment group, six-month mortality rates were 13.7% with MPSS and 20.3% with placebo (p = 0.08). Analysis of data by life table methods showed similar survival rates between MPSS- and placebo-treated patients in Group 1. In Group 2, survival rates were increased in MPSS-treated patients in the intervals from 48 hours through seven days (p = 0.04) and from three months through six months (p = 0.03). A Cox regression analysis showed that the relative risk of death for Group 1 patients was similar, regardless of treatment; Group 2 patients on MPSS had a significantly decreased relative risk of death (p less than 0.01). MPSS treatment was not associated with increased incidence of myocardial rupture, cardiac aneurysm, early malignant ventricular arrhythmias, or other adverse cardiac events.
 ...
PMID:Methylprednisolone as an intervention following myocardial infarction. The Solu-Medrol Sterile Powder AMI Studies Group. 287 3

The authors suggest that the males under 60 with myocardial infarction who have no chronic circulatory insufficiency in their case history should be divided into the groups of high and low risk of the development of ventricular fibrillation, thromboembolic complications and acute cardiac aneurysm. The group of risk is determined on the basis of 5 clinical characteristics: the character of myocardial infarction, the stage of arterial hypertension, evaluation of the general state, heart failure and the heart rate.
 ...
PMID:[Prognosis of ventricular arrhythmias in myocardial infarct patients]. 687 59

Anti-heart antibodies detected by indirect immunofluorescence were found in the blood of persons deceased suddenly of heart failure more often (36,7%) than in those who died of other causes (16,6%). Antibodies were found the most frequently in rheumatic heart failure (50%), in other heart diseases (50%), and in ischemic heart disease (35,5%). In ischemic heart disease there was a high level of antibodies in patients with chronic heart aneurysm (66,6%) as compared with low level in those with acute infarction (16,6%). Obviously, antiheart antibodies often accompany a heart disease without being closely related to the heart failure. A negative result of serological examination does not exclude a heart disease.
 ...
PMID:[Heart antibodies in sudden death]. 712 44

Patients with an untreated myocardial infarction may present with serious late complications. 3 patients are described. A 63-year-old woman became progressively more short of breath 4 days after an acute episode of chest pain accompanied by nausea and sweating. It proved to be a cardiogenic shock following a rupture of a papillary muscle. A man aged 65 collapsed 5 days after an episode of back pain and nausea. This was a cardiac tamponade due to rupture of the left ventricle. A woman aged 74 had transient aphasia and during investigations for this was seen to have anomalies on ECG. She had cerebral emboli and a cardiac aneurysm with associated thrombus. All 3 patients recovered following mitral-valve replacement, repair of the rupture and medicinal treatment for the clot, respectively. Around one-third of patients who have a myocardial infarction do not have chest pain but experience shortness of breath, autonomic nervous symptoms (sweating, nausea, vomiting), extreme and inexplicable tiredness and fainting. These atypical symptoms should suggest myocardial infarction. In order to avoid high morbidity and death from complications such as arrhythmias, heart failure, rupture and aneurysm formation it is important that a patient who has had a myocardial infarction should be treated as soon as possible, preferably by reperfusion therapy.
 ...
PMID:[Complications of an unrecognized myocardial infarction]. 1635 69

The aim of the work was to identify risk factors of atrial fibrillation (AF) in 151 patients with metabolic syndrome (MS, IDF 2005); 88 of them presented with the recurrent form of AE 63 had no arrhythmia. Practically all patients suffered from arterial hypertension. The groups were comparable in terms of age, concomitant disorders, AH duration, arterial pressure, and severity of chronic heart failure. Patients with permanent AF, hemodynamically significant heart disease, myocardial infarction with wave Q in the medical history, and cardiac aneurysm were excluded from the study. We evaluated anthropometric parameters, carbohydrate and lipid metabolism, daily albuminuria, results of echoCG, and insulin resistance. Patients with AF had worse anthropometric and metabolic parameters and more pronounced remodeling of myocardium with left ventricular diastolic dysfunction, insulin resistance, endothelial dysfunction, and renal lesions than patients with MS without AF Patients with MS having abdominal obesity and AH over 10 years, marked insulin resistance (IR index higher than 2.77), reduced HDL cholesterol level (below 1.1 mmol/l), left atrial dilation (end diastolic size >43mm), albuminuria >60 mg/d, waist circumference >104 cm were at high risk of AF (prognostically unfavourable arrhythmia). It is concluded that dynamic observation of the above MS and echo-CG parameters, and albuminuria coupled to the adequate correction of insulin resistance, control of AH and dyslipidemia is important for the prevention of cardiac arrhythmia.
 ...
PMID:[Assessment of risk factors of atrial fibrillation in patients with metabolic syndrome]. 2256 46