Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 110 patients with dermatomyositis cardiovascular pathology was found in 77, and only in 37 of them it was attributable to the underlying pathology. In all of these patients myocardial lesions were found, that manifested themselves most frequently by non-specific ECG changes. Cardiac insufficiency and arrhythmias were revealed less frequently, mainly during exacerbations of the pathological process. Only in one patient endocarditis was diagnosed, and in two others elements of chronic cor pulmonale due to pneumonitis. In 18 patients signs of moderate myocardial dystrophy developed after a long-term therapy with corticosteroid hormones. A study of the central haemodynamics in 20 patients with dermatomyositis revealed a tendency towards a hyperkinetic state of the circulation in those patients who had the most sereve muscle syndrome. Angioscopy of the bulbar conjunctiva revealed the changes that persisted even during the remission period, achieved by means of active steroid therapy.
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PMID:[Cardiovascular pathology in dermatomyositis]. 115 33

Patients with rheumatic mitral diseases and chronic cor-pulmonale associated with pulmonary hemodynamic disorders were examined for the intravital status of microcirculation in the bulbar conjunctiva. Systemic derangement of microcirculation was discovered, with all the components (resistive, metabolic, capacitance) being involved. In patients suffering from rheumatic fever, the analogous microcirculatory alterations were revealed in the conjunctiva and in the visceral pleura of pulmonary biopsy specimens. This reflects the generalized character of microcirculatory response under pathological conditions. The significance of microcirculatory disorders in the pathogenesis of arterial pulmonary hypertension, respiratory and heart failure is under discussion.
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PMID:[The characteristics of the microcirculatory disorders in rheumatic mitral defects and chronic cor pulmonale]. 209 1

Studies on microcirculation in the elderly include observations in the small vessels of the bulbar conjunctiva and of the nailbed with respect to a classification of the findings according to a number of semeiologic criteria (diameter and shape alterations, terminal capillary network, intravascular red cell aggregation). In vascular diseases of the elderly there are typical alterations of the capillaroscopic findings in the bulbar conjunctiva and in the nailbed, particularly in cases of arteriosclerosis, arterial hypertension, diabetic microangiopathy, heart failure, ischemic myocardiopathies. During the treatment with some vasoactive drugs (nicotinic acid and its derivatives, buflomedil, CPD-choline) there are marked modifications of the small conjunctival vessels, with evident dilatations, appearance of collaterals, increased homogeneity of the blood flow, better evidence of the capillary network and reduction of intravascular red cell aggregation.
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PMID:Microcirculation in the elderly. 383 Nov 49

The conjunctival biomicroscopy has been used to study the microcirculation in the bulbar conjunctiva of 88 patients with cardiac insufficiency, 67 of them had its refractory form. The changes found in the microcirculation bed in the refractory and nonrefractory forms of cardiac insufficiency differed as to the extent and a significantly greater expression in the refractory form of cardiac insufficiency.
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PMID:[Characteristics of the microcirculatory status in the bulbar conjunctiva in a refractory form of heart failure]. 708 33

We report a 46-year-old man with bacterial endocarditis and cardiac failure, who developed status epileptics. The patient was apparently well until July of 1991 when there was a gradual onset of fever and general fatigue. He was hospitalized to the cardiology service of our hospital where diagnosis of bacterial endocarditis and aortic insufficiency was made. On October 9, 1991, he suddenly developed cardiogenic shock, and emergency replacement of the aortic valve was made; at the operation, the main trunk of the left coronary artery showed embolic occlusion, and the myocardial movement was markedly diminished; serum creatine kinase was 3.150 IU/l. His cardiac failure did not resolve, and renal failure developed in December 1991, for which peritoneal dialysis was necessary. On February 2, 1992, he suddenly developed a clonic seizure which started from his face with a transient post-ictal left hemiparesis; a cranial CT scan was unremarkable. He was treated with phenytoin and glycerol, however, he developed status epileptics on February 3; he developed cardiac arrest after the injection of phenytoin 750 mg. He was resuscitated, however, his status did not resolve. Neurological consultation was asked on February 4. On physical examination, his blood pressure was 80/40 mmHg heart rate 77/min and regular, and body temperature 39.1 degrees C. The palpebral conjunctiva were slightly anemic, however, the bulbar conjunctiva were not icteric. No cervical adenopathy was noted. Glade II systolic murmur was heard in the apex; the lungs were clear. The abdomen was flat and soft without organomegaly. No edema was present in the legs. On neurologic examination, he was comatose without response to painful stimuli. He repeatedly had convulsion lasting for 30 seconds every 2 to 3 minutes; his convulsions started with the conjugate deviation of the eyes to the left followed by turning of the head toward left, and then clonic convulsions started in this left upper limb extending to other extremities. The optic fundi were unable to visualize because of corneal clouding; light reflex was sluggish on the right side; no oculocephalic response was elicited; corneal reflex was also lost bilaterally. Extremities were hypotonic, and no automatic movement was seen. The triceps brachii reflex was diminished, but all the other deep reflexes were lost; no plantar response was elicited. Meningeal sign was absent. He was treated with intravenous diazepam; the interval of convulsions prolonged, however, blood pressure dropped to 40 to 40 mmHg. On February 4, intravenous thiopental anesthesia was instituted, and assisted respiration was started.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[A 46-year-old man with cardiac failure and statues epileptics]. 794 26

Microcirculatory bed of the epi- and pericardium, parietal pleura, bulbar conjunctiva is studied in congenital heart defects. The alterations of the microvessels were similar in all above organs. The following conclusions are made: a) the reduction of microvessels manifests as capillary failure of the myocardium resulting in cardiomyocyte destruction and development of cardiosclerosis, b) myocardial alterations result in heart failure and enhancement of systemic microhemocirculation, c) irreversible pathological processes can be prevented by early surgery only.
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PMID:[Microcirculatory disorders of the systemic circulation and the myocardium in congenital heart defects with a left to right shunt]. 809 44

Microcirculation of the bulbar conjunctiva and nailbed was studied in 120 patients with chronic renal failure (CRF) and its complications. Peritoneal, pleural and pericardial circulation was investigated in 15 dogs with experimental chronic uremia. It was found that the degree and frequency of microcirculatory disorders in chronic uremia correlate with the stage of CRF and diseases causing CRF. The presence of cardiac insufficiency aggravated CRF. Clinical, morphological, light and electron microscopic examinations of microcirculation in CRF revealed alterations in all the regions of microcirculation. Additional data on etiopathogenesis of cardiovascular disorders in CRF were obtained basing on the changes in peritoneal, pleural and pericardial microvessels in the experimental model of chronic uremia.
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PMID:[Microcirculation bed in chronic uremia]. 1118 91

We describe a case of recurrent Kawasaki disease (KD) in a non-Asian 6-year-old boy who had been diagnosed with typical KD without cardiac involvement at age 3 years. He was admitted to the PICU 3 years later for heart failure, hypotension, and deterioration of his general condition. Ultrasonography revealed left ventricular dysfunction with a 44% ejection fraction and grade I mitral valve failure without coronary artery involvement. Subsequent observation of hyperemic conjunctiva, bilateral cervical adenopathies with erythematous skin (normal neck ultrasound and computed axial tomography findings), peeling of the fingertips at day 8 of the illness, and occurrence of an inflammatory syndrome led to a diagnosis of incomplete recurrent KD with a clinical picture of Kawasaki shock syndrome (KSS). Clinical improvement was rapidly obtained after intravenous immunoglobulin and intravenous corticosteroid therapy (30 mg/kg per day for 3 subsequent days). Left ventricular function gradually improved, with ultrasound returning to normal after 3 months. Diagnosis was difficult to establish because of the recurrence of the disease and the incomplete clinical picture, with clinical features of KSS. Physicians need to be aware of these pitfalls in the management of patients with clinical signs of KD.
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PMID:Kawasaki shock syndrome complicating a recurrence of Kawasaki disease. 2538 85

Fibrosis is a shared end-stage pathway to lung, liver, and heart failure. In the ocular mucosa (conjunctiva), fibrosis leads to blindness in trachoma, pemphigoid, and allergy. The indirect fibrogenic role of DCs via T cell activation and inflammatory cell recruitment is well documented. However, here we demonstrate that DCs can directly induce fibrosis. In the mouse model of allergic eye disease (AED), classical CD11b+ DCs in the ocular mucosa showed increased activity of aldehyde dehydrogenase (ALDH), the enzyme required for retinoic acid synthesis. In vitro, CD11b+ DC-derived ALDH was associated with 9-cis-retinoic acid ligation to retinoid x receptor (RXR), which induced conjunctival fibroblast activation. In vivo, stimulating RXR led to rapid onset of ocular mucosal fibrosis, whereas inhibiting ALDH activity in DCs or selectively depleting DCs markedly reduced fibrosis. Collectively, these data reveal a profibrotic ALDH-dependent pathway by DCs and uncover a role for DC retinoid metabolism.
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PMID:Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy. 2759 39