Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infants with congenital heart disease and chronic lung disease are at risk for development of systemic-to-pulmonary collateral arteries (SPCA). This study characterizes associated clinical findings in 20 premature infants without CHD who were diagnosed as having SPCA with echocardiography. SPCA can occur in premature infants without chronic lung disease and may represent a transient phenomenon.
 ...
PMID:Development of systemic to pulmonary collateral arteries in premature infants. 978 9

CHD is the number one killer of men and women. Men and women need to be educated about the warning symptoms of CHD and MI to assist in earlier diagnosis and treatment. Women need to be taught about the variety of factors that may affect their risk for CHD. All women should be counseled about the importance of primary and secondary prevention, as those with low probability of disease may some day have some form of cardiovascular illness, and those with high probability of disease may prevent or lessen the effects from an infarction. The Women's Health Initiative (WHI) is a study that may answer many of the unresolved questions about women and MI. The WHI was established by the National Institutes of Health (NIH) in 1993 to address negligence of women's health by the major federal research agencies. It is the largest study ever funded by NIH. Forty centers throughout the United States will follow 163,000 women for a 10-year-period to determine how to prevent heart disease, breast and colon cancer, and osteoporosis in postmenopausal women. The age range of women is from 50 to 79 years old. This study will have a major impact upon care of women for these varied conditions. While waiting for the answers to questions about treatment and prevention, we must use what information is available to us now. Women report for care later than men and often do not receive the same therapies and treatments, thus we need to become advocates for the female patient. We need to also assess the social support and caregiver availability that women have at home. If the situation is inadequate then community resources need to be accessed. In addition, follow-up care is essential. Because many women have complications of CHF and shock with their infarcts, we need to assure adequate follow-up. Transportation for the follow-up may also need to be provided or arranged since women's caregivers may be unable to drive their spouses to the doctor's office. Also, single, older women may be unable to use public transportation with ease. We can address the needs of the female population with CHD if we make a thorough assessment and individualize their plan of care. In today's world of health care, meeting an individual's needs is an ongoing challenge because the length of stay is shortened and resources are tighter. Creativity is often needed to adequately meet the assessed needs. In the future, MI may not be the number one killer of women. Preventing the onset of the disease or decreasing the risk of a reinfarction by empowering women may have an impact. It is hoped that the information given in this article could help the health care worker educate and empower women about this disease.
 ...
PMID:Myocardial infarction. The number one killer of women. 944 72

Syndromes of risk factor disturbance may contribute to the development of coronary heart disease and non-insulin-dependent diabetes mellitus, but their definition and quantification remain problematic. Using factor analysis, constellations of risk factor variables that could indicate distinct syndromes of metabolic disturbance were explored in the baseline data of the first follow-up cohort of 742 men from the Heart Disease and Diabetes Risk Indicators in a Screened Cohort (HDDRISC) study. The primary analysis considered 16 intercorrelated variables measured in more than 90% of cohort participants. A missing-values estimation routine was used to ensure inclusion of all participants in the analysis. Subanalyses were undertaken, including a repeat of the primary analysis on the 522 individuals who had received measurement of HDL cholesterol, an oblique rather than orthogonal factor rotation procedure performed on primary and HDL subset analyses, a repeat of these two primary and HDL subset analyses using only those participants with complete measurements, and a repeat of these six analyses including only the seven variables conventionally associated with the metabolic syndrome. The principal factor that emerged in all analyses undertaken comprised oral glucose tolerance test insulin and glucose response, serum uric acid, and body mass index. Fasting serum triglyceride concentration was included in this factor in 11 of the 12 analyses undertaken, fasting plasma insulin in 8, fasting plasma glucose in 5, and mean arterial pressure in 3. HDL cholesterol factored in isolation from insulin in all analyses undertaken. These findings provide strong support for a core metabolic cluster, which is unlikely to include blood pressure and does not include HDL. The factor scores relating to this cluster will provide a means of assessing its quantitative importance in prospective analysis of the development of CHD and diabetes in this cohort.
 ...
PMID:Factors of the metabolic syndrome: baseline interrelationships in the first follow-up cohort of the HDDRISC Study (HDDRISC-1). Heart Disease and Diabetes Risk Indicators in a Screened Cohort. 948 85

Dietary Guidelines have emerged over the past 30 years recommending that Americans limit their consumption of total fat and saturated fat as one way to reduce the risk of a range of chronic diseases. However, a low-fat diet is not a no-fat diet. Dietary fat clearly serves a number of essential functions. For example, maternal energy deficiency, possible exacerbated by very low-fat intakes (< 15% of energy), is one key determinant in the etiology of low birth weight. The debate continues over recommendations for limiting total fat and saturated fatty acid intake in children. Recent evidence indicates that diets with adequate energy providing less than 30% of energy from fat are sufficient to promote normal growth and normal sexual maturation. More attention needs to be devoted to the effect of dietary fat reduction on the nutrient density of children's diets. The association between dietary fat and CHD has been extensively studied. Diets high in saturated fatty acids and trans fatty acids increase LDL cholesterol levels, and in turn, the risk of heart disease. The relationship between high-carbohydrate/low-fat diets and CHD is more ambiguous because high-carbohydrate diets induce dyslipidemia in certain individuals. Obesity among adults and children is now of epidemic proportions in the United States. High-fat diets leading to excessive energy intakes are strongly linked to the increasing obesity in the United States. However, the prevalence of obesity has increased during the same time period that dietary fat intake (both in absolute terms and as a percentage of total dietary energy) has decreased. These trends suggest that a concomitant decrease in total dietary energy and modifications of other lifestyle factors, such as physical activity, also need to be emphasized. Obesity is also an independent risk factor for the development of diabetes. The current availability of fat-modified foods offers the potential for dietary fat reduction and treatment of the comorbidities associated with diabetes. However, to date, few studies have documented the effectiveness of fat-modified foods as part of a weight loss regimen or in reduction in CHD risks among individuals with diabetes mellitus. The association between total dietary fat and cancer is still under debate. While there is some evidence demonstrating associations between dietary fat intake and cancers of the breast, prostate, and colon, there are serious methodologic issues, including the difficulty in differentiating the effects of dietary fat independent of total energy intake. Reported total fat and saturated fatty acid intakes as a percentage of total energy have been declining over the past 30 years in the United States. Despite this encouraging trend, the majority of individuals--regardless of age--do not report consuming a diet that meets the levels of fat and saturated fatty acids recommended by the Dietary Guidelines for Americans. On a relative basis, saturated fat intake has gone down less than has total fat intake. Individuals of all ages who report consuming a diet with < or = 30% of energy from fat consistently have lower energy intakes. Given the increasing rates of obesity in the United States at an earlier and earlier age, dietary fat reduction may be an effective part of an overall strategy to balance energy consumption with energy needs. In each of the age/gender groups reporting consumption of < or = 30% of energy from fat and less than 10% of energy from saturated fatty acids, fat-modified foods play a more important role in their diets than for people who are consuming higher levels of fat and saturated fat. The data are clear than fat-modified foods make a more significant contribution to diets of consumers with low-fat intakes. While one cannot argue cause and effect from the results presented, the patterns of fat-modified foods/low-fat intakes are consistent. The focus on overall diet quality is often lost in the national obsession with lowering fat inta
 ...
PMID:Dietary fat consumption and health. 962 78

Binding of NO to heavy metal-containing proteins probably accounts for many of its physiologic actions. NO inhalation is a promising new treatment for various disorders of neonates. The therapy is most likely to benefit premature neonates who are hypoxemic despite breathing pure oxygen and those who suffer from impaired carbon dioxide elimination. Newborn infants who have congenital heart disease may benefit from inhaled NO therapy if their disease involves some form of pulmonary venous hypertension or if they have recently undergone surgery involving cardiopulmonary bypass grafting. The use of NO in infants with PPHN might obviate the need for ECMO or other invasive treatment methods. Neonates with CDH seem likely to benefit marginally from NO therapy. Minimizing the toxicities of NO inhalation therapy requires that the physicians understand the nuances of infant care. The therapeutic value of increasing carbon dioxide elimination with NO inhalation warrants further investigation.
 ...
PMID:Nitric oxide inhalation therapy for newborn infants. 978 16

Endocarditis is a rare but serious complication often related to complex CHD. The incidence, particularly among smaller infants with cyanotic heart disease, seems to be increasing. The pathophysiology is related to a combination of host and bacterial factors that predispose to endothelial colonization and infection. Diagnosis, although occasionally difficult, is life saving, but the treatment is prolonged. Prophylaxis before appropriate procedures may significantly decrease the risk for development in appropriate patients.
 ...
PMID:Pediatric bacterial endocarditis. Treatment and prophylaxis. 1021 75

The bioavailability in human subjects of non-nutrient plant factors, including dietary flavonoids and phyto-oestrogens, is of great importance relative to their reported health protective effects. These effects include protection against heart disease, and also in the case of the phyto-oestrogens, hormone-dependent cancers. Epidemiological studies have shown flavonoid intake (mostly quercetin) to be inversely associated with mortality from CHD. Quercetin is a potent antioxidant in vitro, and protection against the oxidative damage to LDL implicated in atherogenesis has been suggested as a possible mechanism. Human subjects can absorb significant amounts of quercetin (particularly in the glucoside form) and it would appear to be sufficiently bioavailable to act as an antioxidant in vivo; however, following our recent study (J O'Reilly, TAB Sanders and H Wiseman, unpublished results), it is currently less clear whether quercetin really can act as an antioxidant in vivo. The isoflavone phyto-oestrogens genistein and daidzein are much less effective antioxidants than quercetin in vitro, however, they are well-absorbed by human subjects and appear to be sufficiently bioavailable to act as antioxidants in vivo. In our recent study (O'Reilly et al. 1998) lower plasma isoprostane concentrations and increased resistance of LDL to oxidation were observed following the high-isoflavone dietary phase compared with the low-isoflavone dietary phase. Considerable inter-individual variation in isoflavone metabolite excretion has been observed, in particular the production of equol (the gut bacterial metabolite of daidzein; a more potent antioxidant and more oestrogenic than daidzein), and this appears to be influenced by habitual diet. Further studies on the bioavailability of these non-nutrient plant factors and related influencing factors are clearly still required.
 ...
PMID:The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens. 1034 51

Despite the nearly universal finding from observational studies that postmenopausal estrogen therapy reduces the risk of CHD and the multiple plausible mechanisms by which estrogen might reduce the risk of CHD, hormone therapy had no benefit in the only large randomized clinical trial to date. Although it is possible that estrogen taken over the long term actually reduces CHD risk, it is not reasonable to begin the regimen used in HERS to prevent new or recurrent heart disease, given the observed excess early risk. Given the possible long term benefit, women who are already taking hormone replacement therapy may elect to remain on it. Women who are undecided should be asked to consider participation in clinical trials. The HERS has dramatically illustrated the need for them.
 ...
PMID:Hormones and heart disease in women: Heart and Estrogen/Progestin Replacement Study in perspective. 1037 73

This study was designed to evaluate whether hair calcium concentration reflects the mortality from coronary heart disease on a UK-wide basis and to determine the effect--if any--of environmental factors which might affect calcium metabolism on this relationship. The study was based on our earlier findings of an inverse relationship between hair calcium concentration and that in the intima of the aorta and the association of high aorta calcium with severe alterations to the vessel walls which was found never to co-exist with hair calcium concentrations greater than 700 ppm. Hair samples were collected from 4393 males in an ethically approved study in 40 different health districts. These covered the range in known prevalence of heart disease as reflected in the published standardised mortality ratios (SMR). Data on water hardness were obtained from the Water Authorities and on mean annual sunshine hours from the Meteorological Office. Statistical analysis was by regression and multivariate regression techniques. Hair calcium was determined by XRF analysis and the accuracy validated by means of certified reference samples. Significant relationships were found between health district and county SMR and their respective mean hair calcium concentrations accounting for 37 and 55% of their respective variances in SMR. Water hardness and sunshine hours accounted for 39 and 49% of the variance in mortality from CHD. In combination they accounted for 54% of the variance and with the inclusion of hair calcium 65%. South-east England had the highest hair calcium, the hardest water and the most sunshine hours and the lowest mortality from CHD. The converse was true of Scotland. Hair calcium concentration did reflect the risk of CHD on a population basis and was strongly influenced by both the hardness of the water supply and the annual sunshine hours which also independently affected the SMR for CHD.
 ...
PMID:Relationship of hair calcium concentration to incidence of coronary heart disease. 1089 91

The author summarizes the most frequent health problems and complications of congential heart disease in adulthood. All presented problems n adult patients with CHD emphasize th correct organization and health care of these patients. The basic care has to be provided in place of residence of educated general physicians and cardiologists. However, the treatment of patients with complicated defects required to form specialized centers for both ambulatory and hospitalized patients.
 ...
PMID:[The most frequent health problems and complications in adult carriers of congenital heart defects]. 1115 75


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>