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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Heart failure is a clinical syndrome caused mainly by cardiovascular diseases such as coronary heart disease, hypertension and valvular disease, but several categories of drugs may potentially induce heart failure in patients without previous heart disease or precipitate revealing of heart failure symptoms in patients with preexisting left ventricle impairment. Pathophysiologically drugs that increase preload, afterload or have negative inotropic properties may be able to cause this adverse reaction. In the article the potential role in the occurrence of heart failure of cytostatics, immunomodulating drugs, nonsteroidal anti-inflammatory drugs, calcium channel blockers, beta-adrenoceptor antagonists, antiarrhythmics, anesthetics and antidepressants is reviewed.
Pol Merkur Lekarski 2001 Sep
PMID:[Drug-induced heart failure]. 1176 28

An episode of depression in a patient with Ischaemic Heart Disease is presented. The patient had undergone coronary angioplasty with optimal results. The clinical picture of the depressive disorder consisted mainly of chest pain complaints in the cardiac area, which made the diagnosis all the more difficult. The application of antidepressive treatment caused the depressive symptoms together with the chest pain to disappear. A therapeutic success was achieved owing to the good co-operation between the invasive cardiologist and the psychiatrist.
Psychiatr Pol
PMID:[An episode of depression in a patient with coronary artery disease]. 1184 11

As evidenced by clinical trials, sterols and stanols may reduce LDL-cholesterol more potently than the restriction in the dietary intake of saturated fatty acids and cholesterol. So far, in Poland no clinical trials on the preventive applications of plant sterol margarines were conducted. Therefore, the objective of our study was to confirm their utility in primary prevention of cardiovascular disorders in young, healthy men who habitually consume butter. The present study was conducted on 42 healthy men (24.5 +/- 6 yr)--priests students living throughout the study in a boarding house and 4 weeks consumed during the study the same amounts (portions) of all diet elements, and the only difference were the two compared fats used in the study. 31 men consumed daily 15 g of extra butter (30 g/d), and 31 men consumed twice daily 15 g of margarine (30 g/d) with the addition of plant sterol esters amounting to 8 g/100 g of the product. Total cholesterol reduction by 7% (p < 0.001), and above all the LDL reduction by as much as over 11% (p < 0.001) confirm the beneficial effect of sterols on lipid parameters. The first time we observed reduction of oxidized LDL (oxy-LDL) by as much as 21% (p < 0.001) after consumption of margarine with plant sterol. This results suggest that sterols have pleiotropic effects, similar to statins. Our proposal of this results is that sterol have anti-inflammatory effect, probability by reduction of oxysterols from food. Of note is the fact that dietary sterol intake did not cause any changes in the HDL fraction level. Also the observed reduction in the atherogenic index (LDL-C/HDL-C) by over 11% (p < 0.001). On the other hand, the disadvantageous effect of butter-containing diet on blood serum lipids, with a trend towards their increase, was confirmed in the present study. The results obtained indicate a potent hypolipaemic activity of dietary sterol intake in normocholesterolemics young men, and probably that is the one of the important methods of prevention heart disease.
Pol Arch Med Wewn 2003 Jun
PMID:[The impact of plant-sterol supplemented diet on the LDL and oxidized-LDL levels in young men]. 1456 91

Eosinophilia and pleural effusion may suggest pulmonary eosinophilia. We present a case of 42 years old woman with hypereosinophilia history since 5 months and no evidence of parasitic infections. She had no history of heart disease. Laboratory tests revealed eosinophilia (13.0 x 10(9)/l) and elevated serum IgE (2050 IU/ml), ANCA was not detected. ECP was not elevated. Pleural effusion contained 37% of eosinophils. An ECG revealed low voltage of QRS in all leads and Q waves in leads Vi-V-3. An echocardiography showed enlargement of left auricle and left ventricle with ejection fraction = 35%. The only pulmonary manifestation in this case was eosinophilic pleural effusions associated with congestive heart failure. A women was treated with prednisone 1 mg/kg/d and cyclophosphamide 2 mg/kg/d with clinical improvement and normalisation of eosinophil number in peripheral blood. But echocardiographic picture of the heart was nor better during 2 months of observation.
Pneumonol Alergol Pol 2003
PMID:[Churg-Strauss syndrome--cardiac problem in lung disease department]. 1505 69

Cardiac arrhythmias are the reason of the most sudden deaths in athletes. The annual risk of sudden death at athletes is between 5 to 10 per one million. Benign arrhythmia including bradyarrhythmias, atrial and ventricular premature contractions are common in the athletes. Supraventricular arrhythmias such as atrial fibrillation, nodal reciprocal entrant tachycardia and Wolff-Parkinson-White syndrome are less common. Perhaps the rarest and the most dangerous arrhythmias are ventricular arrhythmias, among them arrhythmias secondary to hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia, long QT syndrome, and anomalous origin of coronary arteries. Asymptomatic bradyarrhythmias (if the heart rate in bradyarrhythmia appropriate increases with exercise), supraventricularis tachycardias, and atrial premature contractions without structural heart disease are not the contraindication to sports Athletes with premature ventricular contraction, nonsustained ventricular tachycardia and non structural heart disease are without athletic restrictions as long as the arrhythmias do not worsen and they not cause dyspnea or presyncope during exertion. Frequent or multiform premature ventricular contraction or sustained ventricular tachycardia indicate a higher risk, and all participation in athletic should be restricted.
Pol Merkur Lekarski 2004 Jan
PMID:[Cardiovascular diseases as a cause of sudden death in athletes]. 1507 12

Vascular parkinsonism has not been well defined and the clinical correlation of vascular parkinsonism is still not clear. The aim of the study was to estimate prevalence of occurrence of vascular parkinsonism, analysis of risk factors leading to its development and to identify clinical features that suggest a vascular origin. 214 patients with Parkinson's disease were examined. Their ages ranged from 37 to 88 years (median 66.4 years). Evidence of vascular parkinsonism was assessed using a vascular rating scale previously described by Winikates and Jankovic. Statistical analysis was performed with Mann-Whitney U test, chi 2 Pearson test, chi 2 Yates test, Spearman rank correlation and Student's t test. Out of 214 patients 8 were proved to have developed Parkinson's disease due to vascular disease, what gave 3.74%. Out of risk factors for stroke 5 patients had hypertension, 3 had diabetes mellitus, 2 suffered from heart disease, 2 had infarctus myocardii, 1 had hyperlipidemia, 1 had atrial fibrillation. Additionally, those patients had neuroimaging (CT or MRI) evidence of vascular disease in one or more vascular territories. Patients with vascular parkinsonism were older, had shorter duration of disease, were more likely to present rigidity rather than tremor. Dementia and incontinence were more common in vascular group than in Parkinson's disease group. Patients with vascular parkinsonism were also significantly more likely to have corticospinal findings. Proving that Parkinson's disease had vascular etiology is extremely difficult. The test results are inconclusive.
Neurol Neurochir Pol 2003
PMID:[Clinical correlation of vascular parkinsonism]. 1509 42

A case of a 5-year-old boy with complex heart disease and acute occlusion of modified Blalock-Taussig shunt is presented. The patient was treated with balloon angioplasty and local infusion of recombinant tissue plasminogen activator without persistent good effect. He was successful treated with the implantation of two coronary stents into the occluded shunt.
Kardiol Pol 2004 Apr
PMID:[Thrombolysis and stent implantation in a child with an acute occlusion of the modified Blalock-Taussig shunt--a case report]. 1522 85

We describe a case of a 59-year-old female with paroxysmal atrial fibrillation and arterial hypertension who had syncopal attacks due to polymorphic ventricular tachycardia (PMVT) with a short coupling interval of an initiating beat (280 msec). We excluded structural heart disease. In the resting ECG the QTc interval was 420 msec. During Holter monitoring a slight changes of the ST-T segment in V1 were observed (from positive T wave with ST elevation of 1 mm to flat or negative T wave without ST elevation). Additionally, after PMVT a large U-wave (4 mm of amplitude) with the QTU interval of 600 msec and QTUc interval of 662 msec were observed. The U wave disappeared 9 minutes afterwards. The ajmaline test was positive for the Brugada syndrome. The patient received ICD and sotalol, and during 6-month follow-up she remains asymptomatic.
Kardiol Pol 2004 Jun
PMID:[Polymorphic ventricular tachycardia with a short coupling interval in a patient with normal heart--a case report]. 1533 60

Congenitally corrected transposition of the great arteries (CCTGA) is a rare form of congenital heart disease characterised by atrioventricular as well as ventriculoarterial discordance. The life expectancy of individuals with CCTGA is limited by the onset of the systemic ventricular failure. There have been only a few patients with CCTGA and age >50 years reported in literature. We describe a 72-year-old man with CCTGA who was admitted to the hospital because of severe congestive heart failure. Our patient s survival is one of the longest ever described.
Kardiol Pol 2004 Jul
PMID:[Congenitally corrected transposition of the great arteries in a 72 year old man--a case report]. 1533 20

Heart failure (HF) is a complex clinical syndrome due to ischaemic heart disease, idiopathic cardiomyopathy, hypertension, valve heart disease and others. It is not clear if the etiology of HF influences decreased in this syndrome exercise tolerance. Controversial is also dependence of cytokine levels on etiology of HF. The aim of the study was to compare exercise capacity and cytokines levels in pts with ischaemic and dilated cardiomyopathy. We analyzed circulating levels of TNF-alpha and its soluble receptors sTNF-RI and sTNF-RII, and interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in 41 pts with CHF, functional class NYHA I-IV, mean EF--25.2 +/- 7.1%. For determination of cytokines level (using R & D System tests) venous blood was withdrawn after 30 minutes of supine rest. All underwent echocardiography and cardiopulmonary exercise stress testing. Dilated cardiomyopathy (DCM) was diagnosed in 21 pts, ischaemic (ICM) in 20 pts. Pts with DCM were younger then with ICM (48 +/- 6.6 vs 56 +/- 6.6 yrs; p = 0.001). There were no significant differences between groups concerning BMI and EF. There were no significant differences in the level of TNF-alpha and sTNF-RI between groups. There was a trend of increased sTNF-RII in pts with ICM (3179.7 +/- 832.7 vs 2699 +/- 680.1 pg/ml; p = 0,07), IL-1beta (2.55 +/- 2.41 vs 1.49 +/- 1.68 pg/ml; p = 0.087) and IL-6 (6.25 +/- 2.21 vs 4.98 +/- 3.64 pg/ml; p = 0.065), and significant increased ESR (11.2 +/- 9.5 vs 5.5 +/- 4.7 mm/h; p = 0.04). Peak VO2 was reduced in pts with ICM group as compared to those with DCM (14.1 +/- 3.7 vs 18.1 +/- 4.8 ml/kg/min; p = 0.0069). In chronic heart failure circulating levels of cytokines tended to be higher in pts with ischaemic origin of the syndrome. The exercise capacity is lower in ischaemic cardiomyopathy.
Pol Arch Med Wewn 2004 Jun
PMID:[Cardiopulmonary exercise testing and cytokines in chronic heart failure. Comparison of patients with ischaemic and with dilated cardiomyopathy]. 1550 92


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