Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a case history of 29-year old female with infective endocarditis, who was admitted 15 months after neurosurgical treatment of disruption of cerebral aneurysm. The diagnosis of organic heart disease had been established in her childhood. 6 months after discharge from neurosurgery she developed marked dyspnoea on exertion and became febrile (up to 39.0 C). The presumptive diagnosis of infective endocarditis was established 6 months later, when she developed the symptoms and signs of severe anaemia with ESR 170 mm/hr although blood cultures were negative. The patient underwent treatment with Penicillin and Debecillin. On admission to our Institute echocardiography showed a very large, mobile vegetation in the left ventricle, connected to the anterior leaflet of mitral valve. Decision of mitral valve replacement was made, but rupture of the next cerebral aneurysm was the reason of unexpected, sudden death of the patient. The postmortem examination revealed 7 x 4 cm large vegetation, with the mass of 7.0 g. Histologically the vegetation consisted of mass of fibrin strands, platelets and blood cell with inflammatory cells. On its base the signs of the process of organization were marked. This vegetation was the largest one that we found in literature on this subject.
Kardiol Pol 1991
PMID:[Unusually large vegetation on the mitral valve in a patient with bacterial endocarditis]. 194 48

The Multivariate risk of developing Ischaemic Heart Disease (IHD) during period of 6 years was estimated for men aged 40-59 years on the basis of 2 Polish populations. Coefficients of multivariate logistic function (MLF) were calculated using sample of 4831 men with 240 cases of IHD. The significant risk factors were: age, total serum cholesterol level, diastolic blood pressure, number of cigarettes smoked, familial history of IHD. For these five significant factors new MLF coefficients were calculated. Discriminant power and goodness of fit for both functions were analysed and no significant differences found. The reduced MLF was applied to construct a simple questionnaire of IHD risk test.
Kardiol Pol 1991
PMID:[Utilization of risk factors in medical practice for ischemic heart disease evaluation]. 204 27

Among 1150 ambulatory 24-hour ecg recordings, those taken from 67 persons no more than 40 years old, suffering from paroxysmal unconsciousness or maladies suggesting paroxysmal arrhythmias, without clinical signs of ischaemic heart disease, valve defects, cardiomyopathies or myocarditis, were chosen for further analysis. Echocardiographic signs of mitral valve prolapse (MVP) were found in 33 persons (23 females), whereas in the next 34 persons (20 females) no evidence of MVP was noted. There were no statistical differences between ages, mean heart rates and incidences of the ST segment depression greater than or equal to 2 mm in these two groups. Prolongation of the QT interval greater than 440 ms was found in 8 persons with MVP and in 3 without MVP. Appearance of the single ventricular extrasystoles, sporadic or frequent, was almost identical in both groups. Whereas polymorphic extrasystoles and/or ventricular couplets were significantly more frequent in the MVP group. Our study shows that MVP is present in about a half of persons no more than 40 years old referring to Holter ecg because of symptoms suggesting arrhythmias, without other signs of heart disease; and that complex ventricular arrhythmias in these patients with MVP are significantly more frequent than in persons with similar complaints without MVP.
Pol Arch Med Wewn 1990 Dec
PMID:[Evaluation of 24-hour ambulatory ECG recording in patients with mitral valve prolapse]. 209 22

40 patients with MVP (mean age 36 years--group I) and 20 controls without any heart disease (mean age 40 years--group II) after thorough clinical examination (including Holter monitoring) were subjected to electrophysiological study for sinoatrial node function assessment. The following parameters were studied (before and after "pharmacological denervation"):, SNRT, CSNRT, SP and SACT (using direct method and Strauss and Narul's method). SN dysfunction was found in 19 patients with MVP (37.5%) and in 3 controls (15%) in 24-hour Holter ecg. In the electrophysiological study SN dysfunction was diagnosed in 13 patients (32.5%) of group I. 10 of them displayed also electrocardiographic symptoms of SN dysfunction. "Pharmacological denervation" of the heart (propranolol 0.1 mg/kg, atropine 0.02 mg/kg) revealed 4 cases of concealed SN dysfunction defining the functional background of abnormalities in 7 out of 13 patients. Our data show that SN dysfunction is common in patients with MVP. Electrophysiological study performed with "pharmacological denervation" may disclose cases of concealed SN dysfunction and define them as functional or organic.
Kardiol Pol 1990
PMID:[Sinoatrial node in primary mitral valve prolapse (electrophysiological study)]. 209 48

45 patients (13 females and 32 males; mean age-37 years) without an organic heart disease underwent the study, on condition that effective transesophageal, ventricular stimulation was achieved. The transesophageal pacemaker SP-5 made by OBR TEMED ZABRZE was used. Ventricular stimulation threshold and a lock of evident retrograde conduction was estimated during ventricular stimulation with a constant cycle length of 500 ms. To assess concealed retrograde atrioventricular conduction, programmed ventricular stimulation of a 50 ms cycle length was applied between late diastole and left ventricular refraction. Concealed retrograde atrioventricular conduction was diagnosed of a sinus impulse reached later ventricles than that during sinus rhythm preceding an examination. There was no evident atrioventricular retrograde conduction in 15 patients (33%). In 9 of them (60%) programmed stimulation revealed concealed retrograde atrioventricular conduction reaching atrioventricular node. Obtained results indicate, that the transesophageal programmed ventricular stimulation enables to examine concealed a-v conduction phenomenon and can be helpful in approximate localization of retrograde atrioventricular block.
Kardiol Pol 1990 Jan
PMID:[Latent retrograde atrioventricular conduction in healthy persons]. 227 79

Morphometric evaluation of cortical neurons in children with congenital heart defect of cyanotic and non-cyanotic++ type was performed. Investigations based on autopsied material included three age groups of 6, 12 and 24 months respectively in both of the two groups with heart defect and in the control group. Formalin-fixed samples taken from frontal, parietal, occipital and temporal cortex were embedded in celoidin and slices were impregnated according to the Golgi procedure. The development of dendrites was estimated using three different and independent morphometric methods. The results were statistically analysed to reveal a putative mutual dependence between the type of disease, age and localization in cerebral hemispheres and development of dendrites. The study disclosed significant differences in the dendritic tree in relation to the heart defect, especially that of cyanotic type as compared with the control group. A comparison between the groups with the heart defect and the control disclosed significant differences in the dendritic tree. The most remarkable difference was noted in the group of cyanotic heart disease in which the development of the dendritic tree was markedly retarded. No differences between particular localizations in cerebral hemispheres have been found. The validity of Golgi method for investigation of neuron structure was emphasized.
Neuropatol Pol 1989
PMID:[Morphological indicators of CNS changes in cyanotic and non-cyanotic congenital heart defects in the developmental age. Nerve cells and their processes studied by staining, impregnation and electron microscopy.I. Development of dendrites studied by the Golgi method]. 248 23

Collagen from tissues of the heart valve, the wall of the left auricle, palatine tonsils and periodontium was studied. The material was taken during surgical procedures, performed for therapeutic reasons, in patients with acquired valvular heart disease (avhd) and congenital heart disease. The obtained results pertain to the content of total collagen as well as to its soluble and insoluble fractions. An increase of the soluble collagen fraction, as compared to the insoluble one, provides support for collagen degradation, and this fact has prompted the authors to conclude that collagen plays a part in the etiopathogenesis of a.v.h.d. The authors suggest that estimation of collagen metabolites, and the amount of soluble collagen in tissues, and particularly in palatine tonsils, may be helpful in identifying persons susceptible to a.v.h.d.
Mater Med Pol
PMID:Collagen content in the heart of patients operated on for valvular heart disease caused mainly by infective endocarditis. 248 61

24 endomyocardial biopsies were performed in children aged 4-18 (x = 12.9) without any complications. The endomyocardial biopsy was performed in 12 patients with the heart failure of unknown origin (6 - restrictive heart disease, 4 - dilated cardiomyopathy with arrhythmias, 2-post-inflammatory dilated cardiomyopathy), in 5 patients with a clinical diagnosis of myocarditis, in 1 with the hypertrophic cardiomyopathy, in 2 cases of the dilated cardiomyopathy without heart failure and in 1 girl with the recurrent exudative pericarditis. Active myocarditis with fibrosis was stated in 2 cases of a restrictive heart disease, mild inflammatory state in 2 patients with a clinical diagnosis of the myocarditis and in 3 others with the dilated cardiomyopathy. All of 7 patients with the myocarditis underwent the immunosuppressive therapy. In the patient with endomyocardial fibrosis the result of left ventricular biopsy corresponded with angiocardiographic diagnosis. Non-specific changes in biopsies were stated in 2 children with the restrictive cardiomyopathy and in 5 with the dilated cardiomyopathy. Bioptic, morphologic lesions in patients with the dilated cardiomyopathy did not correlate with hemodynamic parameters of contractility. Biopsies were normal in 6 subjects. Endomyocardial biopsy influenced on making a decision of the therapy in 9 of 21 patients (42.8%). Diagnosis was verified in 7 patients (38.3%) basing on endomyocardial biopsy. In 18 of 24 subjects (75%) endomyocardial biopsy contributed to the interpretation of the disease pathology.
Kardiol Pol 1989
PMID:[Endomyocardial biopsy in children and adolescents]. 261 40

Pacemaker implantation was performed in 26 children aged from 5 months to 15 years (mean 4.6). The indications for pacemaker implantation were: sick sinus syndrome in 4 patients, III degrees idiopathic A-V block in 2 both with congenital heart disease and III degrees post-op. A-V block in 20 patients. 34 pacemakers produced by seven different companies were implanted. Epicardial electrode was used in all but one patient in whom endocardial electrode was introduced. Demand for impulse voltage was 2.4-5.2 V (mean 4.4 V), impulse duration was from 0.25 ms to 1.65 ms (mean 0.62 ms). Three out of 26 pts. (11.5%) died (1-intraoperative bleeding, 1-ventricular rhythm disturbances, 1-sudden death). In seven children first exchange of the pacemaker (one for mechanic damage and 6 for exhausted batteries) was performed mean 4.3 years after previous implantation. In two children second battery exchange was necessary mean 7.5 years after previous (both exhausted batteries). In five children a damaged epicardial electrodes were exchanged (21%).
Kardiol Pol 1993 Jan
PMID:[Permanent cardiac pacing in children. Personal experience]. 823 Sep 73

Carotid sinus massage (CSM) was performed in 44 patients (23 female, 21 male, mean age 52 years) with recurrent episodes of unexplained syncope and without any organic heart disease. The protocol of examination consisted of 5 s CSM performed unilaterally in supine, upright 60 degrees positions, after administration of propranolol (i.v. 0.1 mg/kg) and during autonomic inhibition (atropine i.v. 0.02 mg/kg after propranolol). The diagnosis of hypersensitive carotid sinus syndrome (HCSS) was established in case of pathologic response to CSM in supine and upright 60 degrees positions. Positive results of CSM was obtained in 15 (34%) examined patients. Cardioinhibitory form of HCSS was recognized in 9 and mixed form in 6 cases. Pathologically augmented carotid sinus reflex was provoked in 8 cases by massage of the right, in 4 cases of the left and in 3 both carotid sinuses. Maximal time of electrical asystole after CSM was 6300 ms while maximal decreased od systolic blood pressure was 70 mmHg. Intravenous administration of propranolol caused decrease of systolic blood pressure approximately 43 +/- 15 mmHg whereas the cardioinhibitory effect of CSM after this drug significantly was increased only in patients with a positive response to CSM in the supine or upright 60 degrees positions. Autonomic inhibition significantly decreased the cardioinhibitory effect of CSM without significant influence on its vasodepressive component.
Kardiol Pol 1993 Feb
PMID:[Carotid sinus massage in diagnosing syncope of unknown origin]. 823 Sep 86


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