Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Echocardiography was used to compare the left ventricular function in 35 cases of congestive cardiomyopathy (COCM), 16 cases of obstructive and 28 cases of non-obstructive asymmetric septal hypertrophy, 43 cases of scleroderma heart disease, 21 cases of ischaemic cardiomyopathy (ICM), 2 cases of restrictive cardiomyopathy, and one case of cardiac amyloidosis. COCM was characterized by left ventricular dilatation, decreased contractility and signs of elevated end-diastolic pressure. In asymmetric septal hypertrophy there was a decreased distensibility of the obstructed left ventricle, both in early and end-diastole, but the pump function remained normal. In scleroderma and amyloid heart disease both the contractility and distensibility of the small, stiff heart were reduced. In restrictive cardiomyopathy the only abnormality was the impaired end-diastolic distensibility. Reduced contractility confined primarily to the interventricular septum and impaired early diastolic distensibility are the characteristic features distinguishing ischaemic cardiomyopathy from COCM. However, echocardiography is not suitable for individual differentiation of ICM and COCM. The COCM can be differentiated from left ventricular aneurysm by M-mode sector scanning technique.
Cor Vasa 1978
PMID:Functional differentiation of various types of cardiomyopathies by echocardiography. 15 92

Cor triatriatum is a rare cardiac malformation occurring in about 0.1% of all congenital heart disease. As symptoms are usually present soon after birth, diagnosis in adulthood is extremely rare. We describe a case of a 33-year-old asymptomatic woman who was referred for echocardiographic examination because of a postural variable systolic click. The anatomy of the malformation and the hemodynamics of the left atrium were accurately assessed by means of conventional transthoracic Doppler echocardiography. The antero-inferior course of the intraatrial membrane inserting proximal to the left atrial appendage was documented in multiple perpendicular planes of examination. All pulmonary veins drained correctly into the proximal compartment of the left atrium. Additionally, a small atrial septal defect communicated between the distal compartment of the left atrium and the right atrium. Using pulsed wave Doppler, no site of pressure gradient could be detected between the two compartments of the left atrium. Thus, conventional transthoracic Doppler echocardiography represents an adequate tool for assessing cor triatriatum in adults. The patient refused transesophageal echocardiography.
 ...
PMID:[Cor triatriatum in adulthood: Doppler echocardiographic diagnosis. Case report of an asymptomatic adult]. 158 46

Research of the relevant international literature on HLA studies in patients with hypertrophic cardiomyopathy yielded controversial results. There are no studies, conducted in sufficiently large groups of patients, that would consider the different functional and morphological forms of the disease. Therefore, the authors carried out detailed typing of 60 Class I and II antigens in 117 patients known to suffer from hypertrophic cardiomyopathy. Values of the relative risk and chi-square test showed a number of possible associations. However, after correction for the number of antigens tested, only HLA-B21 was shown to have a significantly high frequency (in patients with the obstructive form and in those with advanced myocardial hypertrophy, defined as a wall thickness greater than 30 mm). An association with this antigen has previously been demonstrated in a number of cases of ischaemic heart disease, myocardial infarction of young people, and in hypertensive subjects. HLA typing may be helpful in recognizing forms which are not fully typical. In Czechoslovakia, HLA-B21 carriers are at increased risk of developing a serious heart disease manifesting already in young age.
Cor Vasa 1991
PMID:An immunogenetic study in hypertrophic cardiomyopathy. 181 Jul 2

Thiamine administration (200 mg/kg 2 hours before start of the experiment) substantially reduced the myocardial ischaemic lesion in a model of experimental myocardial infarction in the rat. As shown by stereometric analysis of histological heart preparations, the cytoprotective action of vitamin B1 is mediated by increased cardiomyocyte resistance towards ischaemia, i.e., through an adequate increase in the relative volume of the protection zone. Experiments on a model of emotional-painful stress in the rat show that the antiischaemic action of vitamin B1 cannot be explained by a specific cardiotropism of thiamine (the presence of thiamine phosphate buffer depots excludes the manifestation of coenzymatic effects of thiamine under given conditions) but by an antistressor action of thiamine resulting in exclusion of an important pathogenetic link in the mechanism of stress-conditioned cardiopathy.
Cor Vasa 1991
PMID:Thiamine cardiotropism. 191 76

As Cor Triatriatum is a rare congenital cardiopathy and benign after corrective surgery, decisive means of diagnosis are essential. The AA review some descriptive theoretical concepts and make reference to the difficulties, present at times, in diagnosis by cardiac catheterization. They consider Eco-Doppler to be the means of excellence for its recognition describing all aspects that point to the diagnosis of this pathology. Described is the case of a 12 month old baby, in whom some semiological findings had lead to a wrong diagnosis. In the discussion, additional diagnosis is eliminated due to some anatomic characteristics defined by echocardiography.
 ...
PMID:[Cor triatriatum. Echo/Doppler diagnosis followed by immediate surgical correction. Report of a clinical case]. 209 38

A new method of ECG diagnosis, based on a mathematical model of electrical heart generator as a mobile dipole, was clinically verified in 10 healthy subjects and 2 patients with combined cardiopathy and pronounced bilateral ventricular hypertrophy. Electrocardiograms were recorded in 80 unipolar leads from the body surface; recordings were processed by a computer. The output information were the pathways of the heart electrical centre (dipole) during the heart cycle. The trajectories in patients with combined ventricular hypertrophy markedly differed--even in the absence of ECG changes in standard leads--from trajectories in healthy subjects. The new method of ECG diagnosis consequently offers information which cannot be obtained when using conventional and corrected orthogonal ECG leads.
Cor Vasa 1986
PMID:Non-dipole components of the heart electrical field in electrocardiographic diagnosis of combined ventricular hypertrophy. 293 87

On the basis of 5-years intervention results concerning chronic heart and vessel diseases of a check, which is representative for approx. 280.000 inhabitants of defined territories (EBMO-Cor Berlin), the prognose for the time of 5 and 10 years were estimated. It refers to ambulantories with the diagnosis hypertension and coronary heart disease, who were treated in a different way. The fundamental idea was to extract a prognostic index to make possible a choice of the treatment, adequate to the specific disease and its severe degrees, free of chance. The basic requirement of the application of the "Markoff-model" was the evidence of homogeneity concerning transition of severe degrees, used as reference, which was proved by means of the 2-k-chi 2-Felder-test. By using a starting vector of 1000 patients in each case inquiries about the distribution to the severe degrees had been made. The so achieved results illustrate a therapy-dependent susceptibility of these (morphologically defined) population suffering from a heart disease and allow a forecast, estimated also for a longer period, about the extent of the transition of a respecting and with the possibilities of the outpatient practice defined severe degrees of a heart and circulation disease and with that about chance and risk of a patient. By means of the epidemiological reference of the study the result gains special importance for outpatient practice.
 ...
PMID:[Assessment of prognosis with Markov chains in chronic cardiovascular diseases in relation to various therapies]. 340 Feb 96

On the material of 25 children, who died in the first year of life of congenital heart disease, pathomorphological changes in the vessels of the microcirculatory bed of the greater omentum were studied. In 14 patients, the heart disease was characterized by reduced blood inflow to the greater circulation, in 11 children by increased inflow. A dependence of morphological changes in vessels of the microcirculatory bed on the character of disorders in central haemodynamics was documented. Adaptive and pathological changes in the microvessels are distinguished, and their clinical functional significance is assessed. The progressive development of pathological structural changes in the microcirculatory bed is considered a consequence of functional depletion not only of central (cardiac) but also of peripheral (microcirculatory system) adaptive mechanisms.
Cor Vasa 1985
PMID:Microcirculatory disorders in congenital heart diseases with insufficient or relatively excess blood supply to the greater circulation. 399 95

On the basis of literary data and of their own series of 264 adult patients, who were in 1978-1982 subjected to invasive haemodynamic examination for congenital heart disease, 162 patients operated on, and 128 patients followed up for long-term periods after surgical treatment of congenital heart disease in adult age, the authors analyse the causes of late recognition of the disease, operative complications and long-term operative results. It is pointed out that a haemodynamically serious congenital heart disease is indicated for surgical correction even in adult age, and that age itself does not represent a limitation to cardiosurgical intervention. In adult age, it is necessary to anticipate a greater number of complications and a more severe post-operative course, but the long-term results are very good.
Cor Vasa 1985
PMID:Congenital heart disease in the adult. 409 70

The authors examined and operated on five patients with congenital coronary arteriovenous fistulas. Patients suffering from this disease do not exhibit complaints typical of cardiopathy and the results of electrocardiographic and roentgenographic examination lack specific features. The presence of low systolic-diastolic murmur suggests a common arteriovenous coronary orifice and by means of coronarography it is possible to make a topical diagnosis.
Cor Vasa 1982
PMID:Congenital coronary arteriovenous fistulas. 718


1 2 3 4 Next >>