Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Frequency-domain correlative cardiography (FCG) is a new non-invasive technique for diagnosing heart disease. FCG was performed in 110 patients who also underwent coronary cineangiography. 12-lead ECG and treadmill exercise testing to determine its diagnostic role in coronary heart disease (CHD). In the group with CHD 61 had true-positive and 8 false-negative FCG results, while in the group without CHD 30 were true-negative and 11 false-positive. Its sensitivity is 88.4%, specificity 73.2%, correct diagnostic rate 84.3% and predictive value 84.7%. The diagnostic efficacy of FCG is better than those of 12-lead ECG and treadmill exercise test. These results indicate that FCG is a valuable noninvasive method for detecting patients with CHD.
Zhonghua Nei Ke Za Zhi 1990 May
PMID:[Diagnostic evaluation of frequency domain correlative cardiography in patients with coronary heart disease]. 224 90

The clinical classification and characteristics of various types of plateau sickness were reported after analysing 13,403 such cases in Tibet region. The conception of plateau sickness and the opinion of its classification in China and abroad were discussed and the names suggested for various types of the disease were also given. However, the rationality of different classifications of the sickness was questioned according to the present understanding of its pathology and clinical manifestations. It is the opinion of the authors to divide this sickness, first of all, into two categories of acute and chronic and then to subdivide each of them into several types according to clinical symptoms and the pathological changes of principally encroached organs. The acute category was subdivided into 4 types as follows: 1. high altitude acute response (HAAR); 2. high altitude pulmonary edema (HAPE); 3. high altitude cerebral edema (HACE); 4. high altitude children cardiopathy (HACC). The chronic category was subdivided into 5 types as follows: 1. high altitude chronic response (HACR); 2. high altitude erythoblastosis (HAEb); 3. high altitude adult cardiopathy (HAAC); 4. high altitude hypertension (HAHyper); 5. high altitude hypotension (HAHypo). This classification is useful in clinical practice and research.
Zhonghua Nei Ke Za Zhi 1990 Jan
PMID:[Clinical classification of altitude sickness: analysis of 13,403 cases]. 240 Nov 67

31 patients undergoing diagnostic cardiac catheterization for suspected congenital heart disease and 30 normal subjects were examined by pulsed Doppler echocardiography. Spectrum analysis of the shape of flow velocity curve and instantaneous flow velocities of the pulmonary artery during systolic period was made and their ratio calculated. The results showed that there was a remarkable difference between the flow velocity curve of pulmonary hypertension (PH) and that of normal pulmonary pressure. Combining with the characteristics of pulmonary arterial hemodynamics, a preliminary exploration was made on the mechanism of flow velocity curve changes. A ratio of flow velocities--PV% was proposed. The sensitivity and specificity for diagnosing PH with PV% were 94% and 100% respectively. There was a high correlation between PV% and pulmonary artery systolic pressure (r = -0.84) or pulmonary artery mean pressure (r = -0.82). It is concluded that PV% may eliminate many factors that influence the pulmonary artery hemodynamics and is a reliable, practical qualitative and quantitative index for diagnosing PH noninvasively.
Zhonghua Nei Ke Za Zhi 1989 Aug
PMID:[Diagnosis of pulmonary hypertension by pulsed Doppler echocardiography--comparison with cardiac catheterization]. 259 27

The recurrence rate of atrioventricular reentry tachycardia (AVRT) after radiofrequency current ablation (RFCA) of 124 accessory atrioventricular pathways (AP) in 122 patients were reported and the possible causes of recurrence of AVRT were analyzed. Of the 122 patients, 81 were male, 41 female. The average age of the patients was 46.3 +/- 14.4 (14-71) hears. There were 81 manifest AP in 80 patients, 43 concealed AP in 42 patients. 13 of the 124 AP were located in left anterior wall, 59 left lateral wall, 8 left posterior wall, 10 left posterior interventricular septum. 14 right anterior interventricular septum, 2 mid-septum, 14 righy posterior interventricular septum and 4 right free wall. All patients had no organic heart disease. The total recurrence rate of 124 AP in the 122 patients during a follow-up period of 2-25 (13.5 +/- 7.1) months was 4.03% (5/124), with manifest and concealed AP 1.23% (1/81) and 9.30% (4/43), respectively (P < 0.05); left free wall and interventricular septum AP were 2.5% (2/80) and 7.5% (3/40), respectively (P > 0.05); left and right AP were 3.3% (3/90) and 3.1% (1/32), respectively (P > 0.05). The recurrence time was from 0.5 to 60 (15.4 +/- 25.4) days. The recurrence may be related to inaccurate ablation target site, functional and anatomical characteristics of AP, locations of AP, and insufficient ablation energy, etc. It is suggested that AVRT patients receiving RFCA should be followed up for a certain period.
Zhonghua Nei Ke Za Zhi 1995 Mar
PMID:[Analysis of the causes of recurrence of atrioventricular reentry tachycardia in patients treated with radiofrequency current ablation]. 764 38

In order to reduce the misdiagnostic rate of obliterative pulmonary hypertension (OPH), the clinical data was analysed of 126 cases of OPH, including 83 cases of unexplained pulmonary hypertension (UPH) and 43 cases of thromboembolic pulmonary hypertension (TEPH). The results showed that the misdiagnostic rate of UPH and TEPH was 93.98% and 79.07% respectively, with a total misdiagnostic rate of 88.89%. UPH was frequently misdiagnosed as congenital heart disease (63.86%), valvular heart disease (13.5%) and coronary heart disease (9.64%). TEPH was usually misdiagnosed as cardiomyopathy (37.21%), coronary heart disease (18.61%), and valvular heart disease (18.61%). The possible causes of misdiagnosis were discussed.
Zhonghua Nei Ke Za Zhi 1993 Mar
PMID:[Analysis of the misdiagnoses of obliterative pulmonary hypertension]. 815 45

The clinical data of 514 cases of high altitude heart disease (HAHD) were reported, 62 cases of them were autopsied. According to the clinical characteristics and pathological changes, of the myocardlum, a clinical classification of HAHD was suggested. There might be four clinical phases, i.e. aggravating, acute, subacute and chronic. Cases of HAHD with different onset time may show different clinical manifestations of these four phases.
Zhonghua Nei Ke Za Zhi 1995 May
PMID:[A study on the clinical classification of high altitude heart disease]. 856 13

The long-term results of 68 cases of thyrotoxic heart disease (THD) treated with 131I were analysed. 17 of 68 patients have been followed for 2-4 years, 32 for 5-9 years, 7 for 10-14 years, 8 for 15-19 years and 4 for 20-33 years. The mean period of follow up was 9 years. Of the 68 patients, 47 did not respond to antithyroid drug (ATD) therapy. Before 131I therapy, all the patients suffered from one or more of cardiac abnormalities caused by hyperthyroidism such as paroxysmal or permanent atrial fibrillation, cardiac enlargement, cardiac failure, frequent atrial or ventricular extrasystoles, angina pectoris and so on. All patients were given individualized therapeutic 131I dose of 2.59-4.44 MBq per gram of thyroid weight. The total 131I dose for patients was 85.1 MBq to 462.2 MBq. The long-term results showed that 55 cases were cured and 11 cases achieved complete remission. The total effective rate was 97 percent. There was no relapse of hyperthyroidism. Except that 4 cases of early hypothyroidism and 5 of delayed hypothyroidism were diagnosed, there were no other complications. The incidence of postradioiodine hypothyroidism at 5-9 years was 7.4 percent and at 10-33 years 20 percent. Our results indicate that 131I is a simple, safe, economic and effective treatment for THD. Pre-treatment with ATD for hyperthyroidism with cardiac complications is not necessary. 131I should be considered as the treatment of first choice for hyperthyroidism with cardiac abnormalities.
Zhonghua Nei Ke Za Zhi 1995 Sep
PMID:[Long-term results following 131I treatment of thyrotoxic heart disease: a report of 68 cases]. 869 23

Eleven patients with ischemia heart disease (IHD) were treated with low dose aspirin (ASA, 50mg/day) for more than two weeks (ASA group). 29 cases with IHD not taking ASA served as patient control (NASA group) and 13 cases without IHD not taking ASA as normal control. Blood samples for measurement of plasma (serum) TXB2 and 6-keto-PGF1 alpha were simultaneously taken from aortic root (AO) and coronary sinus (CS). The results showed: ASA group had lower plasma TXB2 level in AO blood than NASA group (P < 0.05), but there was no significant difference in plasma 6-keto-PGF1 alpha level between the two groups. Both of plasma and serum TXB2/6-keto-PGF1 alpha ratios in AO blood in ASA group were significantly lower than those in NASA group (P < 0.05 and P < 0.0005 respectively). Plasma TXB2 CS/AO ratio and 6-keto-PGF1 alpha CS/AO ratio in ASA group were significantly lower than those in NASA group (P < 0.05), but not different from those in control group. Both ASA and NASA groups had lower serum TXB2 CS/AO ratios than control group (P < 0.05). The results suggest that low dose aspirin inhibits selectively TXA2 synthesis in systemic circulation and inhibits synthesis and/or release of TXA2 and PGI2 equally (no selectivity) in coronary circulation, but could not completely inhibit intracoronary platelet activation.
Zhonghua Nei Ke Za Zhi 1995 Sep
PMID:[Effects of low dose aspirin on platelet function and prostaglandins metabolism in systemic and coronary circulation in patients with ischemia heart disease]. 869 24

Plasma renin activity (PRA), angiotensin II (ATII), aldosterone (ALD) and atrial natriuretic factor (ANF) were determined in 30 patients with high altitude myocardial hypoxidosis (HAMH) with radioimmunoassay and the data were compared with those of 40 healthy subjects and 26 patients with high altitude chronic cardiopathy (HACC). All of them have been in Lasa, a place with an altitude of 3,658 meter, for a long time. The results showed that PRA and plasma ATII increased significantly (P < 0.05-0.01) and plasma ANF decreased significantly (P < 0.01) in patients with HACC and were higher than those in the control. It is suggested that disturbance of these biologically active substances might play a role in the development of HAMH.
Zhonghua Nei Ke Za Zhi 1995 Dec
PMID:[The significance of changes in plasma renin angiotensin aldosterone system and atrial natriuretic factor in patients with high altitude myocardial hypoxidosis]. 873 58

Analysis of the data from 7188 cases seen in the 1980s two general hospitals in Shanghai and comparison of the data with those in the 1950s, 1960s and 1970s revealed that the percentage of heart diseases among the inpatients in medical wards increased in each decades, from 9.89%, 15.69% 20.91% to 23.54% respectively. The constituent ratios of different etiologic types of heart diseases changed. Coronary heart disease constituted the largest proportion, next in number was rheumatic heart disease and congenital heart disease was in the third place. The incidence of congenital heart diseases, myocarditis, cardiac dysrhythmias without organic heart diseases, cardiomyopathy and endocarditis increased and that of rheumatic heart disease, pulmonary heart disease and hypertensive heart disease apparently decreased, syphilitic heart disease was rarely encountered.
Zhonghua Nei Ke Za Zhi 1996 Jul
PMID:[The trend of changes in etiologic types of heart diseases in Shanghai from 1948 to 1989]. 959 15


1