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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Causes of death among 1598 professional artists were compared with an expected distribution based on the general U.S. population to determine if there were unusual patterns of fatal disease that might be indicative of exposure to hazardous substances in their work environment. Deaths among men and women in the arts were identified from obituaries in Who's Who in American Art published between 1940 and 1969. Among 1253 white male artists, PMRs were significantly elevated for arteriosclerotic heart disease, leukemia and cancers of the bladder, colon, rectum, kidney, and brain. The significant excesses of bladder cancer and leukemia deaths were limited to painters. Proportions of deaths due to colon cancer were significantly elevated among male painters and sculptors. Prostate cancer mortality was slightly higher than expected among painters and significantly elevated among sculptors. Among 345 female artists, painters represented the only specialty category large enough to analyze and excess numbers of deaths due to cancers of the rectum, lung, and breast were noted.
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PMID:Mortality patterns among professional artists: a preliminary report. 407 97

Signal-averaged electrocardiogram (ECG) variables were analyzed in 81 patients with ventricular tachyarrhythmia and nonischemic heart disease using the ART LVP 101 EPX system (Austin, TX): 15 ventricular tachycardia patients with arrhythmogenic right ventricular dysplasia (ARVD), 7 ventricular tachycardia patients with dilated cardiomyopathy, 25 patients with "idiopathic" verapamil-sensitive left ventricular tachycardia, 24 patients with "idiopathic" right ventricular tachycardia, and 10 "idiopathic" ventricular fibrillation (IVF) patients with rbbb pattern and ST-segment elevation in the precordial leads. Data from 52 normal control subjects were also analyzed. The first study was to test the hypothesis of any difference in signal-averaged ECG indices between patients with ARVD and patients with dilated cardiomyopathy. Longer filtered QRS duration and T40 and higher amplitude of the terminal filtered QRS complex outside the end of the standard QRS complex (log V-outside) were noted in patients with ARVD (filtered QRS duration, 172 vs 144 ms, P < .05; T40, 94 vs 62 ms, P < .05; log V-outside, 1.48 vs 0.56, P < .01). Endocardial mapping showed noticeable extension of fractionated electrograms in the right ventricle and longer duration of fractionated intracardiac electrograms in patients with ARVD, which might explain the difference in signal-averaged ECG indices between these two diseases. The second study was to test the hypothesis of and the variables that can suggest the arrhythmogenic substrate in patients with idiopathic ventricular tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Time-domain and frequency-domain analyses of the signal-averaged ECG in patients with sustained ventricular tachyarrhythmia and nonischemic heart diseases. 788 60

Cancer, in all its guises is on the rise along with the population growth. While not the leading cause of death in the world, it may soon garner that unfortunate honor. In the US, it is second only to heart disease. The 'war on cancer' declared in the US by Richard Milhouse Nixon is not being won. At present, treatment modalities are limited to resection, immunotoxins, radiation, chemotherapy, genomeceuticals, and variations on those themes. It is anticipated that with the emerging human genome data, most of these areas will be expanded, with the possible exception of radiation. However, all these approaches have two things in common. First, they have met with limited success. Second, they all work around the similar idea of containment and eradication in situ of the disease. This paper presents an alternative and novel way of looking at the research and treatment options for cancer taking two lessons from history. First, is Plato's dialectic where 'truth' is uncovered by examining a situation from two opposite directions at once. Second, from Sun Tsu's treaty on the Art of War, where he recommends that when faced with a superior opponent, one method of dealing with the situation is to provoke them, anger them, cause them to move. The second tactic wears out the opponent and presents them in a more favorable situation for assault. It is suggested herein that perhaps cancer can be attacked by first assisting its growth, and causing metastasis to a location more favorable to attack with the common mechanisms cited above.
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PMID:Plato, Sun Tsu, and the Art of War (on cancer). Can we learn from history? 1261 32

The current work is the presentation of a new project at the IRCSS San Donato Milanese University hospital, in the sphere of Psychocardiology. Hospitalised children and adolescents often face psychosocial difficulties and the psychological condition of their parents frequently has an impact on their wellbeing. A strong need to take care, beyond the mere cure, is necessary in the hospital settings - that is a need to pay attention also to psychological aspects apart from the medical ones. Art therapy could be an answer for this need: the literature has outlined its efficacy in hospital, also due to the higher inclination of children and adolescents toward creativity. By providing and analysing the drawings of 10 young patients with congenital heart disease (CHD), this study outlines how the art therapy program gives these patients the opportunity to freely and directly express fears and anxieties about medical procedures and their disease. Moreover, through the creation of a tangible product, psychologists can better evaluate the psychological troubles of young patients and provide them and their parents with more focused and personalized support. This study also focuses on the perception of the utility that parents have of this new therapeutic intervention, offered at the Department of Paediatric Cardiac Surgery, confirming that art therapy is perceived as being effective and is definitely a good instrument in helping to "take care" of children and adolescents suffering from CHD.
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PMID:[Art therapy for hospitalised congenital heart disease patients: a method of psychological intervention at the IRCCS Policlinico San Donato Milanese Hospital]. 2436 36

The Third International Right Heart Failure Summit (Boston, MA) convened a group of international clinical and scientific experts in pulmonary vascular disease and right heart disease to explore cutting-edge developments in the mechanisms and clinical management of right-sided cardiovascular disease. The symposium was organized into three distinct sessions, the first of which was titled "Pulmonary Hypertension and the Right Ventricle-Thinking outside the Box" and will be the focus of this review. Three internationally renowned experts in pulmonary hypertension and right heart disease-Drs. Stuart Rich, Sean Gaine, and Harm Bogaard-each delivered provocative lectures. The first lecture, by Dr. Rich, was titled "Current Classification for Pulmonary Hypertension-Why Are We Ignoring the Structural Basis of the Disease?" Rich focused on the current classification system of pulmonary hypertension and provided a unique historical perspective. He also addressed the need to evolve the prevailing conceptual framework of our approach to pulmonary vascular diseases and right ventricular dysfunction, including the future design of pulmonary hypertension clinical trials. Dr. Gaine delivered the second lecture, titled "Treatment Algorithm for Pulmonary Hypertension: Tunnel Vision of our Current Approach." Gaine emphasized the tripartite model of pulmonary hypertension management, namely, supportive measures, pharmacologic therapy, and rescue therapy. Specifically, he detailed how each of these entities is changing as our understanding of the unmet needs in the field of pulmonary hypertension is becoming increasingly apparent. Finally, Dr. Bogaard provided a lecture titled "Treating Right Heart Failure: Why Does the Art of Medicine Lead the Science?" Bogaard provided a stimulating review of cutting-edge translational research of right ventricular function and dysfunction. In particular, he described a variety of molecular and cellular changes that occur in the hypertrophied right ventricle and contrasted those changes that may be adaptive from those that are maladaptive and may be potential therapeutic targets.
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PMID:Pulmonary hypertension and the right ventricle-thinking outside the box (Third International Right Heart Failure Summit, part 1). 2561 Jun 5

The State of the Art in von Willebrand disease (VWD) has been impacted not only by discoveries in the field of haemostasis, but also by changes in practice in other fields. The development of bleeding assessment tools has led to the clarification of bleeding symptoms and phenotype in VWD. New discoveries in the biology and genetics of von Willebrand factor (VWF) are challenging our existing diagnostics and classification(s). An improved understanding of reproductive physiology and the pathology of VWD along with changing obstetric, gynaecologic and haemostatic therapies necessitate an evolving response to the care of women with VWD. The survival of patients with autoimmune disease, malignancies and congenital heart disease along with increasing use of circulatory support devices and extracorporeal membrane oxygenation is increasing the prevalence of acquired von Willebrand syndrome. In each of these challenges, there are opportunities to improve the care of our patients with VWD.
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PMID:State of the art: von Willebrand disease. 2740 77

Obesity, a principal risk factor for the development of diabetes mellitus, heart disease, and hypertension, is a growing and serious health problem all over the world. Leptin is a weight-reducing hormone produced by adipose tissue, which decreases food intake via hypothalamic leptin receptors (Ob-Rb) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) negatively regulates leptin signaling by dephosphorylating JAK2, and the increased activity of PTP1B is implicated in the pathogenesis of obesity. Hence, inhibition of PTP1B may help prevent and reduce obesity. In this study, we revealed that phenethyl isothiocyanate (PEITC), a naturally occurring isothiocyanate in certain cruciferous vegetables, potently inhibits recombinant PTP1B by binding to the reactive cysteinyl thiol. Moreover, we found that PEITC causes the ligand-independent phosphorylation of Ob-Rb, JAK2, and STAT3 by inhibiting cellular PTP1B in differentiated human SH-SY5Y neuronal cells. PEITC treatment also induced nuclear accumulation of phosphorylated STAT3, resulting in enhanced anorexigenic POMC expression and suppressed orexigenic NPY/AGRP expression. We demonstrated that oral administration of PEITC to mice significantly reduces food intake, and stimulates hypothalamic leptin signaling. Our results suggest that PEITC might help prevent and improve obesity.
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PMID:Phenethyl isothiocyanate activates leptin signaling and decreases food intake. 3038 68