Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of people living with advanced heart disease is increasing rapidly as a result of improvements in cardiac treatments, better long-term survival from primary cardiac events, and the increase in the demographic of Americans over the age of 65. Successful living with advanced heart disease now often means patients must manage recurrent challenges to health and function from hospitalizations, exacerbations of illness, and cardiac procedures. Depression, anxiety and strain on intimate relationships are familiar problems for people with advanced heart disease that often go untreated. Though these problems have been studied in populations with acute coronary syndrome, there has been less attention focused on people in later stages of cardiac disease progression. Innovative psychological approaches are needed to address the emotional and behavioral challenges for patients coping with heart failure, implantable cardioverter defibrillators, ventricular assist devices, and heart transplant. This article describes common psychological difficulties for adults living with advanced heart disease and potential psychological targets for intervention. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
 ...
PMID:Living with heart despite recurrent challenges: Psychological care for adults with advanced cardiac disease. 3039 79

Evidence of popular interest in the interrelationships between mind, body, and heart disease dates to Ancient Grecian times and paved the way for modern-day scientific inquiry into the relationships between psychological comorbidities in coronary heart disease. Although the systematic evidence has suggested an association of poor medical prognosis and lower quality of life among patients with coronary heart disease with comorbid psychological conditions, the mechanisms are less well understood. In this selective review article, the epidemiology, mechanisms, screening, and treatment recommendations for 4 common psychological conditions (depression, anxiety, stress, and insomnia) comorbid with coronary heart disease are presented. We focus on the grand challenges and unprecedented opportunities for research in this area considering the methodological and technological innovations of the 21st century. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
 ...
PMID:Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities. 3039 80

The discrete emotion theory of affective aging postulates that anger, but not sadness, becomes increasingly maladaptive during older adulthood in predicting health-relevant physiological processes and chronic disease (Kunzmann & Wrosch, 2018). However, it is largely unknown whether different negative emotions have distinct functional consequences in the development of older adults' physical disease. To start examining this possibility, we investigated whether older adults' daily experiences of anger and sadness were differentially associated with two biomarkers of chronic low-grade inflammation (interleukin-6 [IL-6] and C-reactive protein [CRP]) and the number of chronic illnesses (e.g., heart disease, cancer, etc.). In addition, we examined whether such divergent associations would become paramount in advanced, as compared with early, old age. A community-dwelling study of 226 older adults (age 59 to 93; M = 74.99, SD = 7.70) assessed participants' anger and sadness over 1 week, inflammatory processes, number of chronic illnesses, and relevant covariates. Regression analysis showed that anger predicted higher levels of IL-6 and chronic illness in advanced, but not in early, old age. The age effect of anger on chronic illness was mediated by increased IL-6 levels. Sadness exerted a reversed, but nonsignificant, association with IL-6 and chronic illness, independent of age. No emotion or age effects were obtained for CRP. The study's findings inform theories of health, emotion, and life span development by pointing to the age-related importance of discrete negative emotions in predicting a major physiological pathway to physical health across older adulthood. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
 ...
PMID:Is anger, but not sadness, associated with chronic inflammation and illness in older adulthood? 3107 Mar 99

There is growing interest in relationships between borderline personality disorder (BPD) pathology and physical health outcomes. Diagnostic BPD and BPD-related traits, for instance, have been shown to associate with self-reported cardiovascular disease and various cardiometabolic risk factors. However, potential confounding of these associations by comorbid depression, which itself contributes to risk for heart disease, remains unresolved, and previous research is limited by nearly uniform reliance on self-reported health status. In the present study, we examine the association of BPD traits and contemporaneously assessed depressive mood with instrumented measures of cardiometabolic risk in a midlife community sample (N = 1,295). BPD pathology was measured using dimensional, multi-informant trait measures; depressive symptomology was self-reported; and cardiometabolic risk was indexed via multiple indicators of insulin resistance, adiposity, dyslipidemia, and blood pressure. Structural equation modeling was used to estimate the effects of BPD traits and depressive symptoms on aggregated cardiometabolic risk, adjusting for their shared variance. Results showed both BPD features and depressive symptomatology related to the extent of cardiometabolic risk; when examined simultaneously, only BPD associated independently with risk indicators. In further supporting a link between BPD pathology and cardiovascular disease risk, these findings warrant future work to elucidate intervening behavioral and biological mechanisms. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
 ...
PMID:Borderline personality disorder traits associate with midlife cardiometabolic risk. 3164 68