Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study drew attention to the application of functional magnetic resonance imaging (fMRI) and neuro-psychology in diagnosis of vascular mild cognitive impairment and the exploration of its relevant factors. Specifically, 28 patients with vascular cognitive impairment (VCI) were rolled inro an observation group, and 30 normal people were rolled into a control group. They all accepted MRI examination. The automatic segmentation algorithm based on graph theory was adopted to process the image. The age, gender, disease course, Montreal cognitive assessment (MoCA) score, regional homogeneity (ReHo), and low frequency amplitude (ALFF) levels were recorded. The results showed that there were no significant differences in age, gender, and course of disease between the observation group and the control group (P>0.05). The level of ReHo in the left posterior cerebellum of the observation group was significantly higher than that of the control group (P<0.05).The ReHo level of bilateral cingulate cortex was negatively correlated with MOCA score (P<0.05). The ALFF of bilateral inferior parietal lobe, parietal lobe, and prefrontal lobe in the observation group was significantly lower than that in the control group, and the ALFF of bilateral anterior cingulate gyrus, superior medial frontal gyrus, orbital frontal gyrus, right middle frontal gyrus, and right auxiliary motor area was higher than that in the control group (P<0.05) .Heart diseases such as myocardial infarction and atrial fibrillation are high risk factors for VCI. All in all, the fMRI combined with automatic segmentation algorithm can non-invasively observe the changes of the patient's brain tissue, which can be used in the recognition of VCI. The global network attributes of patients with depression tend to be more randomized and have stronger resilience under targeted attacks.
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PMID:Neurologic factors in patients with vascular mild cognitive impairment based on fMRI. 3325 53