Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of aminophylline on renal function in 10 premature infants with idiopathic apnea are evaluated. The percent increases in creatinine clearance (128 +/- 339%, mean +/- SD) and sodium clearance (196 +/- 304%, mean +/- SD) are variable while the percent increase in fractional sodium excretion (69 +/- 109%, mean +/- SD) is significant. This effect is postulated to be at the proximal tubule and may be modified by the effects of postnatal age and infusion of albumin. Gestational age, birth weight, heart disease, water and sodium intake and ventilatory support did not appear to influence the results. Hyponatremia is a potential consequence of theophylline therapy for apnea.
 ...
PMID:The effects of theophylline on renal function in the premature newborn. 43 87

A study of the variations of plasma and urinary osmolality in patients with acute myocardial infarction and heart failure of different origin was made. It was shown that the plasma osmolality may be related to the clinical evolution of heart disease. The effectiveness of monitoring the osmolality in establishing the alterations of water-electrolyte balance is also reported.
 ...
PMID:Osmolality measurements in heart disease. 67 82

Previous investigations in our unit indicated that acute cardiogenic pulmonary edema is associated not only with an increase in left ventricular end-diastolic pressure and pulmonary arterial wedge pressure but also with a relative increase in colloid osmotic (oncotic) pressure and peripheral hemoglobin concentration. This combination of changes suggested that acute congestive heart failure with pulmonary edema, unlike chronic congestive heart failure, is associated with a contraction of intravascular blood volume. In this study, plasma volume changes were measured before and during the treatment of acute cardiogenic pulmonary edema in 14 patients with arteriosclerotic heart disease. The plasma volume measurement in all 14 patients before the initiation of treatment was either normal or decreased. After treatment with the alpha adrenergic blocking agent phentolamine, the plasma volume increased rather than decreased when measured 4 and 12 hours after the initiation of treatment. During this time colloid osmotic pressure and peripheral hemoglobin concentration progressively decreased. These findings suggest that acute cardiogenic pulmonary edema is associated with the extravasation of large quantities of plasma water from the intravascular compartment into the interstitial compartment and contraction of the intravascular plasma volume. The treatment of acute cardiogenic pulmonary edema is associated with the return of hypo-oncotic fluid from the interstitial compartment back into the intravascular compartment with expansion of plasma volume and reduction of colloid osmotic pressure and hemoglobin concentration.
 ...
PMID:Effect of afterload reduction on plasma volume during acute heart failure. 70 95

Contrast techniques were used in the echocardiological evaluation of a 28-yr-old patient with congenital cyanotic heart disease; catheterization showed an association of an atrial septum defect, a ventricular septum defect, and a patent ductus arteriosus, with equalization of pulmonary artery and systemic pressures. Glucose 5% in water, injected as a 10-ml bolus into an antecubital vein, constituted an adequate echogenic contrast solution. The heart was examined with both a single-crystal transducer (echoes recorded in M mode) and with a 51-elements dynamically focuses multiscan system (echoes recorded on video-tape). Contrast echocardiology showed that right-to-left shunting occurred at the level of the ventricular septum defect and was not significant at the atrial level.
 ...
PMID:Bidimensional real-time echocardiological visualization of a ventricular right-to-left shunt following peripheral vein injection. 91 88

The relation between environmental temperature, heat production, oxygen consumption, and evaporative water loss was studied in 67 infants with congenital heart disease. The majority of the cyanosed infants had a low minimum oxygen consumption, a low evaporative water loss, and a diminished metabolic response to cold stress. Minimum oxygen consumption and evaporative water loss rose in 6 of these infants after the construction of a surgical shunt. Many of the ill acyanotic infants had an abnormally high minimum oxygen consumption, and those in cardiac failure often continued to sweat in an environment below the thermoneutral temperature zone.
 ...
PMID:Oxygen consumption and evaporative water loss in infants with congenital heart disease. 94 28

The relationship of trace elements to arteriosclerotic heart disease (AHD) was assessed. Samples of water supplies in the Houston area were analyzed periodically for cadmium, lithium, iron and zinc. Mortality data for each of the sampling areas, delineated according to boundary of water service, were used to compute average annual age-adjusted death rates for white males aged 35 to 64 during the years 1969 to 1971. Linear regression analyses were performed on the chemical constituents for the age-adjusted death rates due to AHD. Positive correlation coefficients for lithium and zinc were found to be statistically significant at the 0.05 probability level.
 ...
PMID:Distribution of trace elements in the Houston environment: relationship to mortality from arteriosclerotic heart disease. 103 May 41

During 76 extracorporeal circulations (CEC) carried out for open heart operations using an identical protocol, the authors carried out renal function tests from the time of administration of the anesthetic to the post-operative period. Various periods may be distinguished: pre-operative, anesthesia induction (CEC 1, CEC 2) post induction (CEC 1, post CEC 2) finally, the post-operative period (post-operative 1 to 4). As far as renal hemodynamics are concerned, the authors made the following observations: constant reduction in thiosulphate clearance and endogenous creatinine clearance, which reflect glomerular filtration. Reduction in PAH clearance, which reflects renal perfusion. Taking into consideration changes in the hematocrit, one may consider that there is a reduction in renal blood flow at all stages of anesthesia. Taking into consideration concomitant variations in blood pressure, one may calculate that intrarenal resistances are increased. The diuresis/minute increases in very great proportions during induction of anesthesia. Plasma osmolality also increases, urinary osmolality becomes reduced and osmolar clearance rises. The ratio between osmolar clearance and creatinine clearance rises. The clearance of free water rises from negative values. The serum sodium becomes slightly reduced, and sodium diuresis increases. Serum potassium becomes slightly reduced and urinary potassium rises. The interpretation of these phenomena is difficult and should take into consideration the experimental conditions. Comparison with published results shows that there are definite differences depending on whether pure or diluted blood is used. It is however, possible to seek the role of the anesthetic, the thoracotomy or the extracorporeal circulation itself and its load, quite independent of prior changes due to decompensation or not of the congenital heart disease, whether or not it has been treated. The study of these changes in renal function permits one to understand better the precariousness of renal perfusion during extracorporeal circulation, imperfectly corrected by osmotic diuresis and responsible for transient and reversible renal hypofunction, liable to lead however, in cases of complications and prolonged low blood flow, to organic renal failure.
 ...
PMID:[Renal functions and extracorporeal circulation]. 110 26

Changes of the mineral concentrations of the heart muscle can point at disturbances of myocardial metabolism. Disturbances of heart muscle with functional loss and without coronary or inflammatory heart disease are called myocardosis, especially cardioplegic myocardosis after open-heart surgery with extracorporal bypass. 30 dogs were examined in three groups varying the method of induced cardiac arrest: 1. ischemic cardiac arrest by clamping the ascending aorta, 2. functional cardiac arrest by electrically induced fibrillation and 3. ischemic cardiac arrest and in addition injection of a Mg-aspartate-procain-solution. Sodium, potassium, magnesium, calcium, copper and zinc were analyzed by atomic absorption spectrophotometry. Specimens from the left and right ventricular wall were examined before and after extracorporal circulation. After a recovery period for one hour the dogs were killed and specimens from the right and left ventricular wall and from the basis and apex of the interventricular septum were taken and reduced to ashes with mineral acids. In all animals changes of the mineral content were most marked after the recovery period. In all forms of cardiac arrest mineral metabolism showed monotone reactions: water content increased, potassium and magnesium decreased. Variations of mineral concentrations were more expressed in the right ventricular wall than in the left. Animals with cardiac arrest by electrically induced fibrillation indicated the smallest deviations from the basic values. The comparison of the values of dogs with sufficient circulation at the end of the experiments and those dogs with medicamentally or mechanically supported circulation at this time showed a more increased water content and simultaneously a decrease of all cations in the group with supported circulation. The decrease of the osmolality of the cations seems to be the metabolic answer to the increased cardioplegic damage of heart muscle.
 ...
PMID:[Myocardial electrolytes in "cardioplegic" myocardosis (author's transl)]. 122 Jun 68

The arterial resting flow, the arterial peak flow after 3 minutes of circulatory arrest to the leg, and the venous emptying rate were studied by strain gauge plethysmography in the calves of 85 children between 3 and 16 years of age. Most of the children had heart disease; therefore the values obtained can be regarded as reference values only for this type of patient.--The reproducibility of the results of the flow measurements was favourable and equal to that found in the examination of adults and of children using water-filled plethysmographs. --All of the flow functions investigated were significantly higher in the younger children and--but not always significantly--higher in boys than in girls. There was no difference between sides as regards arterial flow, whereas the venous emptying rate was significantly lower in the left calf. --Strain gauge plethysmography is recommended for assessment of circulatory complications after vascular catheterization in children aged 4 years or older.
 ...
PMID:Strain gauge plethysmography for blood flow measurements in the legs of children. 123 10

His bundle electrograms were performed in eight patients with organic heart disease. Recordings were made at various rates utilizing right atrial pacing. A solution of 100 cc of iced cold 5% glucose and water was infused through a cardiac catheter placed at the level of the tricuspid valve. The P-A, A-H, H-Q and H-S intervals were determined before and immediately after the cold water infusion. A significant prolongation of the A-H interval occurred with negligible effects on the P-A, H-Q and H-S intervals. At the atrial pacing rate of 100/min the average A-H interval increased from the control value of 116 to 125 msec after the infusion (P less than 0.02); at the pacing rate of 140/min, the A-H interval increased from 147 to 158 msec (P less than 0.01). This represents an impairment in conduction through the atrioventricular node.
 ...
PMID:Effect of cold isotonic glucose infusion on A-V nodal conduction. 124 7


1 2 3 4 5 6 7 8 9 10 Next >>