Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Generalized hyperpigmentation may be caused by internal diseases, by occasional or occupational intoxications, and by a group of drugs. Seven cases occurring after treatment with amiodarone (Cordarone) are reported, together with one case of argyria and one of mercury poisoning. Several of these cases were initially mistaken for cyanotic heart disease. Silver intoxication may occur after indiscriminate use of currently available silver-containing drugs. It may become even more frequent as a result of antismoking preparations.
 ...
PMID:[Iatrogenic chromodermatoses]. 52 3

A case report in which argyria is mistaken for cyanotic heart disease is described. A discussion of argyria, a benign cosmetic condition resulting from either ingestion or the local application of silver salts or colloidal silver, is presented. It is suggested that by obtaining comprehensive drug histories, maintaining patient profiles, and through patient counseling, pharmacists are in a position to identify and advise on known cases of argyria.
 ...
PMID:Argyria and cyanotic heart disease. 85 66

We examined specimens from explanted human hearts by two-dimensional electrophoresis. The protocol selected includes: (a) solubilization of the sample in a urea-detergent mix; (b) charge fractionation in the presence of urea and nonionic detergent on a pH 4-10 immobilized pH gradient; (c) size fractionation on a polyacrylamide concentration gradient in the presence of sodium dodecyl sulfate; and (d) staining with silver nitrate. The method is sensitive enough for analysis of biopsies in the 1-3 mg range (wet tissue). We saw, for explanted hearts, variations in the protein pattern with the site of sample dissection. Results are presented for 11 explanted human hearts: one control organ and 10 pathological samples. The recorded pathologies included dilatative cardiomyopathy (six cases), valvulopathy (one case), ischemic cardiopathy (two cases), and graft rejection (one case). The patterns for whole extracts as well as for cytoplasmic proteins and myofibril components are compared. Extensive individual variability was observed both between control and pathological cases and among the abnormal samples.
 ...
PMID:An examination of heart proteins by two-dimensional electrophoresis. 331 3

The condition of hemomicrocirculation vessels in congenital heart disease was studied by silver nitrate impregnation of thick sections. Adaptive and pathological alterations in the microcirculatory bed of the heart in various developmental anomalies are described. The role of adaptive alterations of terminal vessels in an abnormal heart in the blood supply to hypertrophic myocardium is shown. It is suggested that pathological alterations in the microcirculatory bed of an abnormally for-med heart are associated with its functional over loading and weakening of coronary circulation. It is concluded that degenerative, focal destructive, and sclerotic processes in hypertrophic myocardium in congenital heart disease may depend on disturbances of microcirculation in the heart.
 ...
PMID:[State of the blood microcirculatory vessels of the heart in congenital defects]. 644 95

The monophasic action potential (MAP) contains a wealth of information about the stat of the myocardium, which makes it very useful for numerous diagnostic and therapeutic applications in patients with heart disease. The silver-silver chloride electrodes which are currently used for the measurement of MAP have poor long-term stability in contact with biological tissue. This study was therefore undertaken with the aim of investigating the electrochemical behaviour of fractally coated leads in terms of their signal-detection performance. Experience gained with these leads in cardiac pacemakers has already demonstrated the long-term stability and biocompatibility of the fractally coated leads. Present results show that, due to their large electrochemically active surface area, fractally coated leads have a very low impedance over a wide frequency range. The negligible polarization artifact of these leads permits the measurement of cardiac potentials immediately after a stimulus. Fractally coated leads are thus highly suitable for the measurement of MAP, and have clear advantages over Ag/AgCl electrodes. The second part of this study reports on the results of MAP measurements using fractally coated leads.
 ...
PMID:[Measurement and analysis of monophasic action potentials using fractally coated electrodes--I]. 763 68

Discordance of functional and structural changes in right and left myocardium has been considerably discovered in various physiologically stimulated hearts and patients with cardiopathy, but the reasons for that have not yet been known. In the present study, induction of stress proteins, i.e. heat shock proteins, was analyzed and compared between the left and right myocardium of normoxic and hypoxic perfused isolated rat hearts by the methods of two dimensional electrophoresis and silver staining. The results showed that three Hsp70 isoforms (molecular weight 68, 70 and 72 k mu) with pI ranging from 6.3 to 7.3 were increased distinctly in both right and left myocardium under the conditions of perfusion as mentioned above. Moreover, the amount of the stress proteins increased in the right myocardiums was higher than that in the left myocardium, indicating that the response of right heart to the stimulus of hypoxic or normoxic perfusions is different from the reaction of left heart, and the extent of protection in left and right heart by stress proteins is unlike. In addition, the activity of catalase was found to be obviously declined in all perfused isolated hearts. It was suggested that the different increase in stress proteins may be due to different structure and status of right and left ventricle and the oxidative stress may be one of the important reasons to induce or enhance the synthesis of stress proteins.
 ...
PMID:[Discordance of increase in stress proteins in right and left myocardium of perfused isolated rat heart]. 1007 37

Severe obstructive sleep apnea (OSAS) is most often accompanied by metabolic syndrome, obesity, diabetes and coronary disease. In its most severe form, it is a life-threatening condition, requiring active and immediate help. Nasal continuous positive airway pressure (CPAP) is the most efficient nonsurgical treatment for patients with OSAS. However, for anatomical, disease-related and subjective reasons, many patients cannot accept this treatment. A permanent tracheostomy may be one alternative in such patients who, in addition, often suffer from extreme obesity and severe heart disease. In this paper, we describe the long-term follow-up results of 7 patients suffering from OSAS and treated with permanent tracheostomy. All the patients (5 men, 2 women) were diagnosed using the static charge sensitive bed method and night-time oximetry for sleep analysis. The mean body mass index (BMI) of the patients ranged from 34 to 60 and the age from 41 to 64 years. All the patients had severe OSAS and long periods of low oxygen saturation (SaO2) levels. Six patients had a CPAP trial before tracheostomy. Only 2 patients tolerated the trial but, despite the continuous use of CPAP, they were nonresponders. Permanent tracheostomy was done according to normal routine in each patient. After primary healing of 2 days, they used silver cannulae, which also allowed them to speak. The patients were evaluated every year after the tracheostomy. After some practical difficulties including proper maintenance of the cannula, all the patients quickly learned the correct management. In postoperative sleep studies, nadir SaO2 levels had improved significantly, obstructive apneas had disappeared and the subjective quality of life had improved. No marked changes in BMI were found.
 ...
PMID:Long-term results of tracheostomy for severe obstructive sleep apnea syndrome. 1135 89

The proteasome is a major intracellular proteolytic system involved in the removal of oxidized and ubiquitinated protein and the induction of certain stress response pathways. In this study, age-dependent alterations in proteasome function were investigated to gain insight into potential factors which contribute to increased susceptibility to various forms of heart disease during aging. Proteasome activity in cellular extracts prepared from Fisher 344 rat hearts was found to decrease with age. These declines in activity were associated with a decreased 20S proteasome content and loss of specific activities. As determined by two-dimensional gel electrophoresis of purified 20S proteasome, the distribution and silver staining intensities of enzyme subunits were found to vary with age, suggesting that alterations in proteasome subunit composition and/or structure are involved in age-related declines in proteasome activity. In addition, age-dependent increases in the levels of oxidized and ubiquitinated proteins, known substrates of the proteasome, were observed. Thus, loss in proteasome function may impair the ability of myocytes to mount an appropriate response to stress, thereby enhancing the susceptibility of the aging heart to cardiovascular disease.
 ...
PMID:Age-dependent declines in proteasome activity in the heart. 1179 86

The goal of this study is to present the clinical and evolutive features of Pneumocystis infection (PCP) in infants admitted in our clinic. We summarise these aspects from 17 cases (10 male and 7 female infants), admitted between 1st January 2004 and 31st May 2005. PCP infection is rare. It represents 1,5/1000 children (17 cases of 11328 total patients) admitted in our hospital. The risk factors for PCP were age between 6 weeks and 6 months (average 3,38 months) low birth weight (average = 2428 grams), low weight for age, prolonged hospital admission (88,23% of the 17 infants were abandoned in nursery). Only one of them had HIV infection and none presented neoplastic disease. The most prominent clinical aspect was tachypnea (average 78 breath/minute, maximum 130). 16 (94,11%) had difficult breathing with chest in-drawing and flaring of ala nasi. 14 (82,35%) had generalised cyanosis. Only two (11,72%) infants had fever. Radiologic aspects were evocative, with diffuse pulmonary involvement in almost all cases (88,23%). 6 infants (35,29%) had pneumothorax and 2 (11,76%) presented pneumomediastinum. Positive diagnosis was made by microscopic examination of secretions from endotracheal tube aspiration (Grocott methenamine silver stain and Romanowsky stain). 14 infants were ventilated with a good outcome--12 surviving infants (85,7%). All infants had a full course of intravenous Co-trimoxazole. The deceased infants had more risk factors--congenital heart disease 1 case, severe cerebral palsy with organic epilepsy 2 cases. The apparent increase of PCP cases can be related to the number of abandoned children in Romanian pediatric hospitals and nurseries.
 ...
PMID:[Pneumocystis pneumonia in infants]. 1653 25

Mulibrey nanism is a rare autosomal recessive growth disorder with prenatal onset, including occasional progressive cardiopathy, characteristic facial features, failure of sexual maturation, insulin resistance with type 2 diabetes, and an increased risk for Wilms' tumor. Mulibrey nanism is prevalent in the Finnish population and appears extremely rare elsewhere. However, cases outside of Finland may be underdiagnosed or misdiagnosed as having the 3-M or Silver-Russell syndrome, two important differential diagnostic disorders. Here, we report the first Australian patient with mulibrey nanism, in whom the occurrence of Wilms' tumor suggested the correct diagnosis. This was confirmed by the identification of two novel mutations in tripartite motif protein 37 (TRIM37) encoding a RING finger ubiquitin E3 ligase. Both mutations, the p.Cys109Ser B-box missense mutation and the p.Glu271_Ser287del in-frame deletion in the tumor necrosis factor receptor associated factor (TRAF) domain alter the subcellular localization of TRIM37. As both the B-box and the TRAF domains are predicted to be important for mediating the protein-protein interactions, these mutations may help the understanding of the cellular interactions of TRIM37. Our findings imply the importance of early molecular diagnostics in cases of suspected mulibrey nanism and of identifying novel mutations with potential relevance for unraveling the underlying molecular pathology. Ultrasound surveillance for Wilms' tumor is recommended for children with mulibrey nanism.
 ...
PMID:Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism. 1710 Sep 91


1 2 Next >>