Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Furazolidone (FZ) at 700 ppm was added to feed mixtures fed turkey poults 2--5 weeks after hatching to induce acute experimental cardiomyopathy. Poults in the control pen received the same ration but without FZ. From EKG data obtained at weekly intervals, poults were selected for sacrifice at 5 and 10 weeks of age. Poults were sacrificed by cervical dislocation and appropriate samples of tissue from the left ventricle, liver, pectoralis and tibialis cranialis muscles were removed for glycogen assays. Character of glycogen, as determined by percent of branching and number of glucose units per segment, was not significantly altered in poults with spontaneous round heart disease or FZ-induced cardiomyopathy. This suggests that the glycogen accumulation noted in these conditions most closely resembles type II glycogenosis.
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PMID:Characterization of glycogen in selected tissues of turkey poults with spontaneous round heart disease and furazolidone-induced cardiomyopathy. 27 49

Furazolidone (FZ) at 700 ppm was added to feed mixtures fed turkey poults two weeks posthatching to induce acute experimental cardiomyopathy. Poults in the control pen received the same ration but without FZ. Four of the control poults developed spontaneous round heart disease. From EKG data and blood samples obtained at weekly intervals, poults were selected for sacrifice at 5 weeks of age. Tissue samples from the left myocardial wall, liver, and pectoralis major and tibialis anterior muscles were analyzed for glycogen by biochemical assay. Blood glucose was determined with the Technicon autoanalyzer. Deposition of glycogen increased significantly (p less than 0.05) in the myocardium of all affected poults and in the liver of all FZ-treated poults. Glycogen levels of the pectoralis major and tibialis anterior muscles were not affected by FZ, but a significant increase (p less than 0.05) was apparent in the pectoralis major muscle of spontaneous round heart poults. It was concluded that FZ influences glycogen metabolism, probably by enzyme inhibition, and that it tends to magnify effects seen in the spontaneous round heart syndrome. Glycogen infiltration of tissues such as the heart and white skeletal muscle suggests that the round heart syndrome may be a manifestation of the glycogen storage disease, idiopathic generalized glycogenosis. Lack of significant differences in the blood serum glucose levels of all poults indicates that these levels are not a reliable clinical parameter for monitoring development of the round heart syndrome.
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PMID:Blood glucose and tissue glycogen levels in turkey poults with spontaneous round heart disease and furazolidone-induced cardiomyopathy. 120 Sep 48

Furazolidone (FZ) was given to turkey poults two weeks post-hatching by stomach tube in doses of 60 and 80 mg/kg per day, and via the feed at a concentration of 700 ppm. Oral doses were given either as one dose at 8 a.m. or as two equal doses given at 8 a.m. and 4 p.m. Electrocardiographic (ECG) recordings were used to monitor the development of round-heart disease (RHD) and necropsies were performed on all poults to corroborate the ECG findings. All poults receiving FZ gained significantly less weight (p less than or equal to .05) than control poults. At oral doses of 80 mg/kg per day, the apparent acute toxicity of FZ resulted in high mortality during the first week of the experiment. At necropsy there were no signs of RHD in these poults. Most of the poults given FZ orally in doses of 60 mg/kg per day or at 700 ppm in the feed survived to the termination of the experiments. The majority of these poults showed ECG patterns that are typical of RHD. Myocardial lesions indicative of RHD were present at necropsy.
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PMID:The production of cardiomyopathy in turkey poults by the oral administration of furazolidone. 727 47