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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Arterial oxygen tension was measured from radial artery samples in 276 infants referred for cardiological investigation. Values obtained during air breathing in infants with congenital heart disease showed considerable overlap between 'cyanotic' and 'acyanotic' groups, and are of limited diagnostic use. By contrast, values obtained while breathing oxygen in concentrations of over 80%, measured in 182 infants, allowed clear differentiation between these groups. All infants with acyanotic, but only 2 of 109 with cyanotic lesions, achieved an arterial oxygen tension of more than 150 mmHg. In the cyanotic group the response to oxygen breathing was significantly greater in common mixing situations and in the hypoplastic left heart syndrome than with either pulmonary outflow tract obstruction or transposition of the great arteries. Infants with transposition had a significantly lower mean arterial oxygen tension in air than infants with other forms of cyanotic congenital heart disease. Of 23 infants whose final diagnosis was primary lung disease but in whom cyanotic congenital heart disease had been suspected, 7 achieved arterial oxygen tensions of more than 150 mmHg during oxygen breathing, and on this basis cardiac catheterization was not performed. We therefore conclude that measurement of the arterial oxygen tension while breathing high concentrations of oxygen should be routinely performed in the initial assessment of sick infants with suspected congenital heart disease.
Arch Dis Child 1976 Sep
PMID:Arterial oxygen tension and response to oxygen breathing in differential diagnosis of congenital heart disease in infancy. 99 25

In a necropsy series of 75 patients with endomyocardial fibrosis who died during the years 1967 to 1971 in Mulago Hospital, Kampala, the site of the lesions in the heart was studied alongside with the age, clinical history, geographical distribution, heart weight and concurrent diseases. Most frequently involved were the posterior cusp of the mitral valve, the left ventricular wall (upper-mid and/or apical region) and the right ventricular wall wheras othter localisations turned out to be relatively rare. Intracardial thrombi were also often described. Rheumatic heart disease was the most important concurrent cardiac disorder. The range and variety of the lesions is discussed together with relations to age, sex and geographical distribution of the patients. The results give support to Shaper's hypothesis concerning the aetiology of endomyocardial fibrosis; however many unanswered questions about the disease remain.
Trop Geogr Med 1976 Sep
PMID:The variety in endomyocardial fibrosis. A necropsy study. 100 87

The comparison of nine examples of trisomy for the distal segment of 11q permits definition of a clinical syndrome which includes the following: axial hypotonia with hypertonia of the limbs; an old-looking wrinkled face; a large beaked nose; microretrognathia with malformation of the palate; low-set ears; a prominent anterior helix; a prominent anthelix; a short neck; a narrow chest with nipples set widely apart; micropenis in the boys; congenital heart disease; renal agenesis or malformations of the urinary tract; agenesis of the thoracic girdle; dysplasia of the acetabulum; clubfeet.
Ann Genet 1975 Sep
PMID:[Trisomy 11q. Individualization of a new syndrome]. 108 Sep 82

In this study of low birth weight infants (less than 2500 g), we compared the birth weight distribution of patients with patent ductus arteriosus associated with prematurity with that of patients having congenital heart disease other than patent ductus arteriosus. Among 1436 low birth weight infants 37 infants had congenital heart disease other than patent ductus arteriosus and 198 had isolated ductus arteriosus. Infants with congenital heart disease had a mean birth weight of 2018 grams (standard deviation = 370 g) which was significantly greater than that of infants with patent ductus arteriosus. Four of the 37 infants with congenital heart disease other than ductus arteriosus were among 1150 low birth weight infants born in this institution, an incidence of 3.5/1000 live low birth weight infants. Seventy-eight of the 198 infants with patent ductus arteriosus were among 1150 low birth weight infants born in this institution, an incidence of 70/1000 live low birth weight infants. Twenty-one of the 37 infants with congenital heart disease were of appropriate weight for gestational age and 16 were small for gestational age.
Circulation 1975 Sep
PMID:Congenital heart disease in low birth weight infants. 115 51

Two patients are described who presented with congestive heart failure and were found to have an atrial septal defect with a pulmonary blood flow approximately twice the systemic blood flow. Most of the usual clinical signs of atrial septal defect were absent, and the diagnosis was established by right heart catheterization and radioisotopic angiography. Both patients had hypertension and coronary artery disease. Atrial septal defect in the adult patient may not be recognized because of associated cardiac disease, including coronary artery disease and hypertension, or pulmonary disease which may obscure the usual clinical signs of a septal defect. Radioisotopic angiography and right heart catheterization should be considered in any patients with heart disease or congestive failure of obscure cause even if the usual diagnostic signs of atrial septal defect are absent.
Chest 1975 Sep
PMID:Occult atrial septal defect in adults. 115 34

Echocardiography is a new noninvasive tool which provides real-time motion visualization of intracardiac structures for the evaluation of anatomy and physiology in patients with congenital heart disease. This paper is presented to acquaint the pediatrician with the utilization and potential of this technique as practiced by pediatric cardiologists. A discussion of principles of physics and instrumentation in echocardiography is followed by a description of normal echocardiographic anatomy. Specific malformations which can be diagnosed reliably by this technique include: hypoplastic left heart syndrome, transposition of the great vessels, tetralogy of Fallot, idiopathic hypertrophic subaortic stenosis, mitral valve prolapse, and pericardial effusion. In addition, the evaluation of patients with atrial septal defects and patent ductus arteriosus is discussed. New advances in instrumentation and their potential impact in pediatric cardiology are reviewed.
J Pediatr 1975 Sep
PMID:Pediatric echocardiography: a review of its clinical utility. 117 31

An association of ocular colobomata and congenital heart disease was observed in seven patients. Two of these were maternal half sisters whose mother also had ocular colobomata. All the patients had normal karyotypes. There was a high incidence of other associated abnormalities involving the central nervous, skeletal, and urogenital systems. Discovery of an ocular coloboma should alert the clinician to search for other abnormalities.
J Med Genet 1975 Sep
PMID:Ocular colobomata, cardiac defect, and other anomalies: a study of seven cases including two sibs. 117 80

The mortality during the first year after operation was studied in 209 patients with intertrochanteric fracture of the femoral neck, all treated with osteosynthesis. The excess mortality due to the fracture and operation proved to be about 20 per cent. Among the great majority of patients who did not have significant cardiac symptoms or signs despite their advanced age, the excess mortality was below 10 per cent. Among patients whose operative risk had been deemed increased due to heart disease, the excess mortality during the first year was about 50 per cent.
Acta Orthop Scand 1975 Sep
PMID:Mortality in intertrochanteric fracture of the femoral neck. 118 26

Few cases have been reported of the combination of right aortic arch with isolation of the left subclavian artery in childhood because of the absence of symptoms from this pairing of defects and the difficulty of its recognition by routine examination. All the reports have been associated with congenital heart disease. We report 4 cases. In one of them, the diagnosis was made during an attempt to create a left Blalock-Taussig anastomosis and the technique was modified. The diagnosis can be made before operation with an aortogram. This procedure should be carried out to show the aortic arch branches in cases where palliative surgery is contemplated.
Br Heart J 1975 Sep
PMID:Surgical implications of right aortic arch with isolation of left subclavian artery. 119 54

The influence of percutaneous catheterization of the femoral vessels on the arterial peak flow (APF) and the venous emptying rate (VER) of the calves was studied with strain gauge plethysmography in 112 children 2-16 years of age, who underwent arterial (49 cases) or venous catheterization, mostly because of heart disease. The conditions on the catheterized side were compared with those on the other side, and the pre-catheterization values were compared with those obtained after completed catheterization. The catheterization procedure was proved to have no general influence on APF or VER, although it may have an effect in individual patients. APF was not affected at arterial or venous catheterization in children older than 8 years of age. In the younger children, APF was slightly decreased on the catheterized side after arterial as well as venous catheterization. This was considered to be caused by arterial spasm. On the following day APF was normal. A few patients in this age group had a marked reduction in APF caused by intense spasm or thrombotic occlusion after arterial catheterization. These patients will be accounted for separately. VER on the catheterized side was not significantly influenced after venous or arterial catheterization, irrespective of the age of the patients.
Pediatr Radiol 1975 Sep 15
PMID:Percutaneous catheterization of the femoral vessels in children. I. Influence on arterial peak flow and venous emptying rate in the calves. 123 37


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