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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The AA. have observed some patients suffering from persistent chronic hepatitis, aggressive chronic hepatitis, severe virus hepatitis, hepatic cirrhosis, hepatic metastasis, cholecystolithiasis, hepatic abscess, congestic heart disorder, alcoholism also patients treated with barbiturics and benzodiazepine, comparising in the meanwhile gamma-glutamyl-transaminase. They would suggest a new interpretation: the observed enzyme was higher in the obstructive diseases, gamma-GT also notable higher in the cellular hepatic diseases (hepatitis, cirrhosis and so on). In their opinion gamma-GT should be a regular enzymatic screening for liver diseases, but should not anyway eliminate the till now used enzymes.
Quad Sclavo Diagn 1976 Sep
PMID:[New views referred to gamma-glutamyl-transpeptidase (author's transl]. 1 13

15 infants with cyanotic congenital heart disease (pulmonary atresia, Ebstein-Syndrom) were treated with Prostaglandin E1. During treatment there was a significant rise of PO2 and SO2 in the arterial, capillary and central venous blood. There was a minor rise of pH and HCO3; the arterial pCO2 fell slightly. We used PGE1-therapy as pretreatment before the heart operation, so that the critical babies go to the operation well oxygenated and in a better state. The side effects we observed (tachypnoe, tachycardia, hyperpyrexia, augmented urine output, erythemas, apnoic spells) seemed less important than the great advantage of a better oxygenation of these hypoxic babies.
Klin Padiatr 1977 Sep
PMID:[Prostaglandin E1: effect on blood gases in infants with cyanotic congenital heart disease (author's transl)]. 2 23

Consecutive autopsy of 1,000 cases of the aged disclosed coronary sclerosis in 428 cases, myocardial infarction in 137, cardiac hypertrophy in 237, valvular heart disease in 120, conduction disturbances in 96, cor pulmonale in 41, pericarditis in 39, and congenital heart disease or anomalies in 28. There were 343 morphologically normal hearts. A total of 1,022 heart diseases were found in 657 cases, corresponding 1.6 heart diseases per one heart. Heart diseases in the aged were divided into (1) those continuing from the younger period and (2) those specifically found in the aged. The latter were non-inflammatory valvular diseases and chronic conduction disturbances. Mitral regurgitation, including mitral ring dilatation (10), mitral ring calcification (9), spontaneous rupture of the chordae tendineae (2) and calcified aortic stenosis (12) and degenerative aortic regurgitation of prolapsed cusp (35) were produced by various degeneration of the connective tissue of the valves. A total of 59 cases of conduction disturbances consisted of complete or advanced heart block (15), right bundle branch block (RBBB) (16), RBBB with left axis deviation (17), and left bundle branch block (LBBB) (11). Forty-seven cases showed main lesions in the branching portion of the AV bundle and origin of the bilateral bundle branches, which were closely related to the degeneration of the central fibrous body and fibrosis at the summit of the ventricular septum. The common field, where the valvular diseases and conduction disturbances occurred, was the fibrous trigone of the heart.
Jpn Heart J 1975 Sep
PMID:A clinicopathological study of the heart diseases in the aged. The morphological classification of the 1,000 consecutive autopsy cases. 12 9

Eighty patients with various forms of heart disease were studied with the use of a newly developed ultrasonic system having 20 transducers arranged in a linear array. This system allows visualization of the heart in two dimensions in real time. All 15 patients with the mitral valve prolapse syndrome, 13 patients with mitral stenosis, five patients with pericardial effusion, four patients with atrial septal defect, and one patient with left ventricular dyssynergy were properly recognized with this system. One of five patients with hypertrophic myopathy and one of four patients with congestive myopathy were not recognized with this system. Criteria for the recognition of these system. Criteria for the recognition of these conditions are presented as well as the probable cause for false-positive and false-negative diagnoses in this series. Since only qualitative criteria were used, it was not possible to differentiate patients with coronary artery disease or patients with left ventricular volume overload from patients without cardiac pathology. The accuracy of this new system was judged against the clinical examination, conventional echocardiography, cardiac catheterization, and left ventricular angiography. It is assumed that the criteria for diagnosis developed during this study will be supplemented and the equipment improved in the future; however, the ease of operation of this system and the relative accuracy of diagnosis at this stage of its development are extremely interesting. It presents an excellent opportunity to obtain additional information about the cardiac patient without using invasive procedures and without risk.
Am Heart J 1975 Sep
PMID:Diagnostic accuracy of an ultrasonic multiple transducer cardiac imaging system. 12 12

The authors recommend that the "single ventricle" be differentiated into two types. There are single ventricles of the left ventricular type, and others of the primitive type; in other words, the chamber is typically left ventricular or cannot be differentiated into left or right. In the latter case we are dealing with a primitive chamber. In addition there may be variations of the large vessels. Of 40 patients with a single ventricle of the left ventricular type, ten showed normal topography of the major vessels, 13 had a d-transposition and 17 an 1-transposition. In the d-transposition, the outflow track of the ventricle was anterior and to the right and the aorta arises in front of the pulmonary artery; in the 1-transposition and sub-aortic portion is anterior and to the left, the aorta is ventral and to the left of the pulmonary artery. In the discussion it is pointed out that the "single ventricle" must be included in the differential diagnosis of cyanotic, congenital heart disease. Angiographic confirmation of the "single ventricle" depends on the demonstration of an absent ventricular septum and of two separate atrio-ventricular valves.
Rofo 1975 Sep
PMID:Single ventricle: a new angiographic classification. 12 24

The extent and rate of left ventricular wall thickening during systole has previously been shown to be a useful measure of regional ventricular function and to play an important role in the ejection of blood from the left ventricle. The relation among systolic wall thickening, the directional components of contraction, ejection fraction and force velocity measurements is therefore of interest in understanding the dynamics of contraction of the intact ventricle. This report describes a theoretical basis and method for using ventricular angiograms to quantify the separate contributions of longitudinal shortening, circumferential shortening and systolic wall thickening to overall ventricular performance in man. One hundred twenty-two patients with valvular, coronary or myocardial heart disease were studied with biplane angiocardiography during diagnostic cardiac catheterizations. The percent contribution of directional components to total work or power developed by a mid-wall equatorial element of myocardium was shown to be: longitudinal, 14 percent in normal and diseased ventricles; circumferential, 45 percent in normal, increasing to 55 percent in dilated ventricles (P less than 0.005); wall thickening, 40 percent in normal, decreasing to 31 percent in dilated ventricles (P less than 0.001). Thus, left ventricular contraction, which is expressed as systolic wall thickening, quantified separately from inward wall displacement due to mid-wall circumferential shortening, accounts for nearly half of segmental left ventricular work and power. The rate and extent of ventricular wall thickening correlated closely with ejection fraction (r = 0.92 and 0.95, respectively) and with velocity of circumferential shortening (r = 0.90 and 0.80, respectively). Previous models of ventricular and myocardial mechanics that include computations of mid-wall longitudinal and circumferential stress and strain do not appear to account for the large contribution of systolic wall thickening to the performance of the intact heart. Force-velocity relations as heretofore described may therefore be partial descriptors of myocardial function in the intact ventricle.
Am J Cardiol 1976 Sep
PMID:Analysis of wall dynamics and directional components of left ventricular contraction in man. 13 32

The Chilean population exhibits a very low risk for colo-rectal cancer. The farm workers have a high-fibre, low-saturated-fat diet and also an extremely low age-adjusted death rate for colonic and rectal cancer, in each sex. A highly significant positive correlation between age-adjusted death rates from arteriosclerotic heart disease in males and colonic and rectal cancer death rates suggests that high levels of saturated fats and/or cholesterol in the diet may be incriminated for high death rates from large bowel cancer. It is concluded that high plant fibre content and low levels of saturated fats and/or cholesterol in the diet may be important factors influencing the very low age-adjusted death rates from colo-rectal carcinoma in Chilean farm workers.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1976 Sep 24
PMID:High-fibre, low-saturated-fat diet and the aetiology of colo-rectal carcinomata in a low-risk population. 13 12

This study was aimed to evaluate the noninvasive method of radioisotopic angiocardiography for detecting a disproportionate thickning of the interventricular septum relative to the left ventricular free wall in the patient with idiopathic hypertrophic cardiomyopathy. The experimental study was performed to compare the imaged size of myocardial wall obtained my filling up with technetium 99 m labeled sponge in biventricular cavities, with the actually measured thickness of the heart specimen. The resultant correlation between actual and imaged size of the left ventricular wall was excellent (r = 0.95). In the clinical application of this method, a gated cardiac blood pool scan was performed after the intravenous administration of technetium 99 m labeled human serum albumin in a dose of 10 mCi. The cardiac images were obtained in anterior, 30, 35, 40 and 45 degree left anterior oblique projection, and evaluated by visual inspection and semi-quantitatively by tracing the myocardial borders. As a result, the imaged asymmetric septal hypertrophy was evident in all four patients with PMD, with a ratio of septum to left ventricular free wall of 1.35 compared to 0.76 in five patients with left ventricular hypertrophy of known heart disease, and 0.88 in twenty-one miscellaneous cardiac patients without left ventricular hypertrophy. Thus, RI angiocardiography provides a safe, repeatable method for detection and evaluation of Primary Myocardial Disease.
Hokkaido Igaku Zasshi 1976 Sep
PMID:[RI angiocardiography of idiopathic cardiomyopathy (author's transl)]. 13 76

Among the causes of death of 43 scoliotics were 5 directly due to complications of congenital heart disease. Over half (57.9%) of the remaining 38 died of cardiac or respiratory causes. The paralytic scolitoics tended to die of pneumonia or respiratory failure, while the nonparalytic scoliotics died of cardiac failure. Right ventricular hypertrophy was present in 65% of the 17 subjects examined postmortem. Electrocardiographic evidence of right ventricular hypertrophy correlated well with the postmortem findings. The vital capacity was less than 1.75 liters in 84% of the dead subjects. The case records of a further 719 living scoliotics were examined for evidence of congenital heart disease. This was found in: 34 (4.5%) of the whole group of 762, 6.9% of the congenital ; 3.4% of the idiopathic scoliotics; 22.7% of those with Marfan's syndrome.
Clin Orthop Relat Res 1978 Sep
PMID:Causes of death, right ventricular hypertrophy, and congenital heart disease in scoliosis. 15 77

Substantial pig mortalities due to heart disease caused by EMC virus infection are described. The majority occurred in 1970 in conjunction with a rodent plague, but retrospective diagnosis of occasional similar mortalities in previous years was possible. Mortality rates in pigs aged 3 to 16 weeks ranged from a few percent to over 50% and the rate was generally highest in younger animals. It is likely that a considerable proportion of cases was sub-clinical. Focal or diffuse pale areas occurred in the myocardium, the wall of the conus arteriosus being most severely affected. In a few animals, resolving lesions were present. Encephalomyocarditis virus was consistently recovered from pigs with acute heart lesions, but not from those in which myocardial fibrosis had commenced. The virus was demonstrated in rodents, although the dependence of pig disease on rodent-derived virus could not be established. Because of similarities between EMC and FMD myocarditides in pigs, specific diagnosis by virus isolation and identification should be obtained whenever possible.
Aust Vet J 1975 Sep
PMID:Encephalomyocarditis virus infection of pigs. 1. An outbreak in New South Wales. 17 73


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