Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levels of high density lipoprotein (HDL) in the blood are negatively correlated with heart disease and factors which regulate the levels and metabolism of this important lipoprotein are being investigated by many laboratories. Following the identification in liver of two candidate HDL receptors, HB1 and HB2, we undertook in the present studies, an examination of various other rat tissues for the identification of similar proteins. Using specific antibodies against each of the binding proteins, we identified both HB1 and HB2 in several other tissues (intestine, lung, kidney, ovary ...) and further, revealed relative differences in the expression of HB1 and HB2 between various tissues. A most interesting observation was the presence of HB1 but not HB2 in the spleen. Since the two proteins are not represented equally in all tissues, it is conceivable that these putative receptors have different functions in HDL metabolism or in other biological processes yet to be determined.
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PMID:Distribution of high density lipoprotein binding proteins among various tissues in the rat. 788 56

The protection against coronary artery disease attributed to high density lipoprotein (HDL) may be associated with several functions, including its central role in reverse cholesterol transport, possible antioxidant and antithrombotic properties and others not yet identified which may depend on specific interactions between HDL and cell receptors. Several HDL-binding proteins have been identified including two candidate liver HDL receptors, HB1 and HB2 recently purified in this laboratory. We now report the cloning, sequencing, and some properties of HB2, the most abundant of the pair. It shows significant homology with the adhesion molecules ALCAM and BEN of the immunoglobulin superfamily and the cDNA, when transfected into HepG2 or COS cells, caused specific HDL3 binding to increase by 80-100%. Further, ligand blotting of glycoproteins isolated from phorbol 12-myristate 13-acetate-treated THP-1 cells or from transfected HepG2 and Chinese hamster ovary cells also provided evidence of increased binding of HDL3 to HB2. Differentiation of THP-1 cells into macrophages resulted in a striking increase in HB2 mRNA which was attenuated if cells were cholesterol-loaded by incubation with acetylated low density lipoprotein. If the interaction between HDL and HB2 reduces the adhesion-induced inflammatory cellular events that characterize arterial wall injury, thereby achieving the protection associated with higher plasma levels of HDL, these findings may provide a clue to one mitigating effect of HDL in heart disease.
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PMID:Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins. 920 82