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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The importance of supporting energy production in heart cells and the preservation of the mitochondria in these cells will be the focus of a new frontier in cardiovascular prevention, treatment, and management. Many physicians are not trained to look at heart disease in terms of cellular biochemistry; therefore, the challenge in any metabolic cardiology discussion is in taking the conversation from the "bench to the bedside." An understanding of the vital role that adenosine triphosphate (ATP) plays in the heart is critical for any physician or clinician considering therapeutic options that support ATP production and turnover in jeopardized cardiac muscle cells. Metabolic therapies that help cardiomyocytes meet their absolute need for ATP fulfill a major clinical challenge of preserving pulsatile cardiac function while maintaining cell and tissue viability. D-ribose, L-carnitine, and coenzyme Q10 work in synergy to help the ischemic or hypoxic heart preserve its energy charge. This article introduces how ATP, diastolic heart function, and metabolic support help maintain cardiac energy by preserving ATP substrates. Part 2 will investigate an in-depth biochemical discussion of congestive heart failure with physiologic, pathophysiologic, and treatment considerations.
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PMID:Metabolic cardiology: the missing link in cardiovascular disease. 1928 82

The article describes the impact of weight training, micro-elements and vitamins on rehabilitation in post-myocardial infarction patients. Cardiac rehabilitation is a multi-disciplinary and multi-faceted intervention aimed at restoring well-being and retarding disease progression in patients with heart disease. It has been shown that exercise-based cardiac rehabilitation is effective in reducing total and cardiovascular mortality. Intake of vitamins and other diet supplements was reported to exert beneficial effects. Pharmacological medication is associated with an increased risk of severe arrhythmia, and many adverse outcomes. Therefore, since conventional medicine only relieves the symptoms, cellular nutrition should be used in order to improve the quality of life in post-myocardial infarction patients. These elements prevent another infarction. The following nutrients are reported to have beneficial effects on general and cardiovascular health: amino acids, vitamins, coenzyme Q10, pycnogenol, inositol, omega-3 fatty acids, macromineral elements, and trace mineral elements. In conclusion, the review indicates that appropriate weight training and diet supplementation ensure full recovery and elimination of risk factors for cardiovascular diseases.
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PMID:Weight training and appropriate nutrient supplementation as an alternative method to pharmacological treatment in rehabilitation of post-myocardial infarction patients. 2302 20

Epidemiological data show a rise in the mean age of patients affected by heart disease undergoing cardiac surgery. Senescent myocardium reduces the tolerance to ischemic stress and there are indications about age-associated deficit in post-operative cardiac performance. Coenzyme Q10 (CoQ10), and more specifically its reduced form ubiquinol (QH), improve several conditions related to bioenergetic deficit or increased exposure to oxidative stress. This trial (Eudra-CT 2009-015826-13) evaluated the clinical and biochemical effects of ubiquinol in 50 elderly patients affected by severe aortic stenosis undergoing aortic valve replacement and randomized to either placebo or 400 mg/day ubiquinol from 7 days before to 5 days after surgery. Plasma and cardiac tissue CoQ10 levels and oxidative status, circulating troponin I, CK-MB (primary endpoints), IL-6 and S100B were assessed. Moreover, main cardiac adverse effects, NYHA class, contractility and myocardial hypertrophy (secondary endpoints) were evaluated during a 6-month follow-up visit. Ubiquinol treatment counteracted the post-operative plasma CoQ10 decline (p<0.0001) and oxidation (p=0.038) and curbed the post-operative increase in troponin I (QH, 1.90 [1.47-2.48] ng/dL; placebo, 4.03 [2.45-6.63] ng/dL; p=0.007) related to cardiac surgery. Moreover, ubiquinol prevented the adverse outcomes that might have been associated with defective left ventricular ejection fraction recovery in elderly patients.
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PMID:Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects. 3274 73

Comorbidities, dietary supplement use, and prescription drug use may negatively (or positively) affect mental health in cardiovascular patients. Although the significance of mental illnesses, such as depression, anxiety, and schizophrenia, on cardiovascular disease is well documented, mental illnesses resulting from heart disease are not well studied. In this paper, we introduce the risk factors of mental illnesses as an exploratory study and develop a prediction framework for mental illness that uses comorbidities, dietary supplements, and drug usage in heart disease patients. Particularly, the data used in this study consist of the records of 68,647 patients with heart disease, including the patient's mental illness information and the patient's intake of dietary supplements, antibiotics, and comorbidities. Patients in age groups <61, gender differences, and drug intakes, such as Azithromycin, Clarithromycin, Vitamin B6, and Coenzyme Q10, were associated with mental illness. For predictive modeling, we consider applying various state-of-the-art machine learning techniques with tuned parameters and finally obtain the following: Depression: 78.01% accuracy, 79.13% sensitivity, 72.65% specificity, and 86.26% Area Under the Curve (AUC). Anxiety: 82.93% accuracy, 82.86% sensitivity, 83.35% specificity, and 88.45% AUC. Schizophrenia: 87.59% accuracy, 87.70% sensitivity, 85.14% specificity, and 92.73% AUC. Disease: 86.63% accuracy, 95.50% sensitivity, 77.76% specificity, and 91.59% AUC. From the results, we conclude that using heart disease information, comorbidities, dietary supplement use, and antibiotics enables us to accurately predict the mental health outcome.
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PMID:Prediction of Mental Illness in Heart Disease Patients: Association of Comorbidities, Dietary Supplements, and Antibiotics as Risk Factors. 3318 35


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