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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diagnostic value of a scope of peripheric parameters of thyroid function was assessed in an unselected group of untreated patients with suspected thyroid disorder, further in untraeted selected patients (without cardiac involvement) and in treated patients. Comparison of relative values of individual tests was performed, based on relation to plasma thyroid hormone level represented by PBI. It was found that: 1. The diagnostic value of heart rate, plasma cholesterol level, B. M. R. and Hegglin's sign (T-2s interval) is of a very limited degree. 2. The diagnostic accuracy of AJT, Q-Kd interval and PEP was found to be of considerable interest even in unselected patients. Values of IRVD and D indices found for these tests are comparable and allow the immediate estimation of thyroid function in bedside diagnosis. 3. The diagnostic value of PEP could be enhanced by exclusion of patients with suspected or proved cardiac disorder or myocardial failure; this may be useful for physiologic studies. 4. While heart rate is profoundly and inconsistently influenced by beta-blockade, AJT is influenced to a minimal degree only and Q-Kd and PEP are uniformly shifted to higher values, allowing thus diagnostic evaluation during this form of treatment also. 5. As Q-Kd is considerably age-and height-dependent, AJT and PEP are believed to be the most suitable test for immediated clinical diagnosis.
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PMID:Comparison of diagnostic accuracy of different peripheric parameters of thyroid function. 6 35

To evaluate myocardial function in patients with documented mitral valve prolapse (MVP) 14 patients (six men and eight women with a mean age of 28 +/- 6.3 years) were examined noninvasively. Systolic time intervals were recorded at rest (in the supine and upright position) and after bicycle ergometry (upright position) and were compared with 10 healthy control subjects of similar age. Tracings were coded with random numbers and were evaluated by two blinded investigators. Contractility indices such as pre-ejection period index (PEPc) and ratio pre-ejection period/left ventricular ejection time (PEP/LVET) revealed no significant differences between patients and controls both at rest and after exercise. We conclude that young patients with MVP have no evidence for impaired myocardial function, provided there is no significant mitral incompetence or associated heart disease.
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PMID:Noninvasive assessment of myocardial function in young patients with mitral valve prolapse. 42 76

Externally recorded STI were compared with invasively determined EF in 10 normal subjects and 86 patients with various forms of chronic heart disease. From phono-, apex-, and electrocardiograms and carotid pulse tracings, recorded without rigidly controlled conditions (postabsorptive state, fixed time of day, exclusion of atrial fibrillation, and discontinuation of cardiac drugs), PEP, electromechanical interval, isovolumic contraction period, and LVET were measured and deltaPEP (deviation from predicted normal) and PEP/LVET were drived. EF was determined with biplane angiocardiographic methods. Patients were divided into groups based on pathophysiology and state of clinical compensation. The ability of STI to discriminate abnormal from normal function, as compared with EF, varied with each noninvasive parameter and with each physiologic group. On a group basis, the discriminatory ability of PEP was better than that of other noninvasive parameters studied, but did not always parallel that of EF. PEP also tended to correlate better with EF than the other noninvasive measurements. On an individual patient basis, however, the ability of even PEP to predict EF was poor. It is concluded that the usefulness of assessing left ventricle function in chronic heart disease by STI is limited.
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PMID:Noninvasive assessment of left ventricular function in chronic heart disease. 55 80

This study was designed to evaluate the usefulness of non-invasive parameters in the follow-up of cardiopathic patients without valvular cardiac diseases. In 49 patients suffering from heart disease we have studied the changes of radiologic cardiac measurements and systolic time intervals (STI) in the 4 functional classes of the NYHA classification, investigating also the existence of any relationship between these different parameters. Only the patients in the 3rd and the 4th functional classes showed significant changes in STI and radiologic measurements, as compared with the control group. Moreover, significant negative correlations have been observed between relative heart volume and LVET (r = 0.69, P less than 0.001) and LVETc (r = 0.82, P less than 0.001) and positive correlations between relative heart volume and PEP (r = 0.59, P less than 0.01) and PEP/LVET ratio (r = 0.75, P less than 0.001). These results, while confirming the close correlation between STI and cardiac performance, seem to demonstrate that relative heart volumetry is a fairly accurate index of the cardiac conditions in non-valvular heart diseases.
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PMID:Correlation between systolic time intervals and roentgen findings in normal subjects and cardiopathic patients. 73 35

In the recent years an increasing attention has been focused on the systolic time intervals (STI) as reliable indicators of left ventircular contractile performance. As regards the diagnostic usefulness of STI in old persons only few papers can be found in the literature, all of them being concerned with subjects aged less than 90 years. With the aim to assess the usefulness and the reliability of the method and the caracteristics of left ventricular function in the tenth decade, STI as well as heart volume (HV) were determined on a group of 35 subjects aged 90 years and over (mean age 93.2 years) normotensive and free from clinical evidence of heart disease. STI (PEPI, LVETI, QS2I, PEP/LVET) values showed no differences with those considered as normal. A marked increase was recorded for the HV values. These results suggest that in the very advanced age a good level of left ventricular contractile performance can be mantained by the compensatory mechanism represented by heart dilation according to the Frank Starling principle.
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PMID:[Polycardiographic researches on over 90 years old subjects (author's transl)]. 75 76

Left ventricular function of a sample of subjects with chronic alcohol intake, in the form of wine, and without clinical or electrocardiographic signs of heart disease was compared with that of a sample of normal control subjects using non-invasive polygraphic recordings. The statistical analysis has shown significant prolongation of PEP, PEPI, an increase in PEP/LVET, and a shortening of LVET and LVETI in the alcoholic subjects compared with the controls. All these abnormalities may be ascribed to left ventricular malfunction.
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PMID:Preclinical abnormaltiy of left ventricular function in chronic alcoholics. 83 35

The change in systolic time intervals from before exercise to three to four minutes following a maximal-exercise treadmill test was measured to eveluate chest pain in 110 fasting supine subjects. Forty-six (85 percent) of 54 patients with chest pain and with abnormal findings on coronary arteriograms were found to have at least a 10-msec prolongation in the left ventricular ejection time index (LVETI), whereas only two (8 percent) of 25 subjects without heart disease and 5 (16 percent) of 31 subjects with chest pain but with normal findings on coronary arteriograms had 10 msec or more of prolongation of the LVETI after exercise. The change in the other systolic time intervals (total electromechanical systole, preejection phase [PEP], and PEP/LVET) were less reliable in detecting the presence or absence of coronary disease. We conclude that determination of LVETI before and after maximal-exercise treadmill testing is a clinically useful noninvasive disgnostic test for obstructive coronary disease in patients with chest pain.
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PMID:Systolic time intervals before and after maximal exercise treadmill testing for evaluation of chest pain. 85 45

Indirect systolic time indices were used to evaluate serial changes in left ventricular function during pregnancy in 13 normal patients and five patients with compensated cardiac conditions. Changes in both groups tended to parallel each other. In both groups, serial LVET index decreased, PEP index increased, and PEP/LVET ratio increased. Q-S2 index decreased in the normal group in midpregnancy and was inconsistent in the cardiac group. In the immediate postpartum period, LVET index returned to baseline values but PEP and PEP/LVET remained increased in both groups. Results of multiple comparison tests demonstrated that the largest (or smallest) value of each systolic time interval during pregnancy was observed in either the periods of the weeks 28 to 34 or 34 to 38. No significant differences were noted in intergroup comparison between the normal and cardiac groups. These data suggest that consistent changes in cardiac function may be determined during pregnancy by the noninvasive technique of indirect systolic time interval evaluation. These changes may reflect a change in left ventricular contractility, preload or afterload. The differences may persist even in the immediate postpartum period when cardiac output and heart rate have decreased to normal, suggesting residual changes in intrinsic left ventricular function. In patients with compensated heart disease, indirect tests of left ventricular function generally reflect the changes in normal pregnant women.
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PMID:Cardiac performance during pregnancy: serial evaluation using external systolic time intervals. 113 Apr 38

The systolic time intervals were studied in 16 surgical patients without heart disease between 29 and 75 years of age by a non-invasive technique before and after an induction dose of enibomal (Narcodorm). The pre-injection period/left ventricular ejection time-ratio (PEP/LVET-ratio) increased between 8 and 60% and (1/PEP-2) decreased between 3 and 50%, indicating a reduction of myocardial contractility under the influence of enibomal. Factors responsible for circulatory depression during barbiturate anaesthesia are discussed.
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PMID:The effect of the short-acting barbiturate enibomal (Narcodorm) on systolic time intervals. 113 91

An indirect and direct estimate of the left ventricular performances were compared in 45 patients with hypertension, arteriosclerotic heart disease and miscellaneous diseases. In results, externally measured LVET, ET/PEP, PEP and a wave ratio correlated well with internally measured myocardial function. Therefore it was concluded that this convenient and atraumatic method was useful as a valid and sensitive measure of myocardial performance.
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PMID:[Correlation of external cardiac indices with internal parameter of left ventricular function in hypertension and ischemic heart disease (author's transl)]. 115 99


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