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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This review of corn oil provides a scientific assessment of the current knowledge of its contribution to the American diet. Refined corn oil is composed of 99% triacylglycerols with polyunsaturated fatty acid (PUFA) 59%, monounsaturated fatty acid 24%, and saturated fatty acid (SFA) 13%. The PUFA is linoleic acid (C18:2n-6) primarily, with a small amount of linolenic acid (C18:3n-3) giving a n-6/n-3 ratio of 83. Corn oil contains a significant amount of ubiquinone and high amounts of alpha- and gamma-tocopherols (vitamin E) that protect it from oxidative rancidity. It has good sensory qualities for use as a salad and cooking oil. Corn oil is highly digestible and provides energy and essential fatty acids (EFA). Linoleic acid is a dietary essential that is necessary for integrity of the skin, cell membranes, the immune system, and for synthesis of icosanoids. Icosanoids are necessary for reproductive, cardiovascular, renal, and gastrointestinal functions and resistance to disease. Corn oil is a highly effective food oil for lowering serum cholesterol. Because of its low content of SFAs which raises cholesterol and its high content of PUFAs which lowers cholesterol, consumption of corn oil can replace SFAs with PUFAs, and the combination is more effective in lowering cholesterol than simple reduction of SFA. PUFA primarily lowers low-density-lipoprotein cholesterol (LDL-C) which is atherogenic. Research shows that PUFA has little effect on high-density-lipoprotein cholesterol (HDL-C) which is protective against atherosclerosis. PUFA generally improves the ratio of LDL-C to HDL-C. Studies in animals show that PUFA is required for the growth of cancers; the amount required is considered to be greater than that which satisfies the EFA requirement of the host. At this time there is no indication from epidemiological studies that PUFA intake is associated with increased risk of breast or colon cancer, which have been suggested to be promoted by high-fat diets in humans. Recommendations for minimum PUFA intake to prevent gross EFA deficiency are about 3% of energy (en%). Recommendations for prevention of heart disease are 8-10 en%. Consumption of PUFA in the United States is 5-7 en%. The use of corn oil to contribute to a PUFA intake of 10 en% in the diet would be beneficial to heart health. No single source of salad or cooking oil provides an optimum fatty acid (FA) composition. Many questions remain to be answered about the relation of FA composition of the diet to various physiological functions and disease processes.
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PMID:Food uses and health effects of corn oil. 225 33

The role of iron was evaluated in pigs that died suddenly of microangiopathy (mulberry heart disease) characterized by myocardial and endothelial cell damage and capillary microthrombosis. Myocardial iron concentration (mean +/- SD) in pigs with microangiopathy (416 +/- 87 micrograms/g, dry weight) was significantly (p less than 0.001) higher than in pigs with other diseases (294 +/- 93 micrograms/g) and in healthy slaughter pigs (231 +/- 43 micrograms/g). Similarly, hepatic iron concentration in pigs with microangiopathy (1,211 +/- 254 micrograms/g) was significantly (p less than 0.001) higher than in pigs with other diseases (873 +/- 296 micrograms/g) and in healthy slaughter pigs (831 +/- 284 micrograms/g). The results indicate that myocardial and hepatic iron concentration was increased in pigs with microangiopathy. Increased myocardial and hepatic iron concentration might have promoted oxidative stress in selenium-vitamin E-deficient pigs and thus contributed to the development of oxidative damage.
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PMID:Increased myocardial and hepatic iron concentration in pigs with microangiopathy (mulberry heart disease) as a risk factor of oxidative damage. 240 Jan 99

Mulberry heart disease persists among young pigs in Denmark although abundant supplies of selenium and vitamin E are added to feedstuffs for sows and pigs. The concentrations of selenium and vitamin E in the liver and heart tissues of young pigs which had died suddenly, and had the characteristic lesions of mulberry heart disease post mortem, were not significantly different from the concentrations found in pigs of the same age which had died suddenly for other reasons. The concentrations of selenium and vitamin E in the livers (0.3 mg/kg and 4 mg/kg, respectively) appeared to be satisfactory in all the pigs examined.
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PMID:Mulberry heart disease in young pigs without vitamin E and selenium deficiency. 275 46

The containment of damaging oxygen species by antioxidant nutrients has led to the speculation that the RDA for these specific nutrients may be overly low. Among these nutrients are vitamin E, vitamin C, and to a lesser extent beta-carotene and selenium. Evidence for the role of these nutrients in cancer and heart disease is evaluated. The case is presented for an increase of two-fold for the vitamin C RDA and between three and five-fold for vitamin E; for establishing 15 mg as the RDA for beta-carotene; for no change in the vitamin A RDA; and for further study on selenium.
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PMID:Dietary supplementation with antioxidants. Is there a case for exceeding the recommended dietary allowance? 366 21

Forty-eight intact male pigs were used to investigate the influence of source of protein supplement, corn moisture content, and supplemental vitamin E-selenium survived the cidence of mulberry heart disease, hepatosis dietetica and associated lesions. Pigs fed soybean meal-high moisture corn diets survived fewer days than pigs fed the other diets. None of the pigs fed torula yeast-dry corn or soybean meal-high moisture corn without supplemental vitamin E-selenium survived the 13 week trial. Supplemental vitamin E-selenium increased survival of pigs. A higher incidence of hepatosis dietetica, myocardial degeneration, skeletal muscle degeneration, and exudative diathesis was observed in pigs fed torula yeast-dry corn or soybean meal-high moisture corn than pigs fed soybean meal-dry corn. Supplemental vitamin E-selenium resulted in a reduction in the incidence of the above lesions by approximately 50% with the exception of hepatosis dietetica. Tissue selenium concentration did not appear to be related to the incidence of the various lesions.
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PMID:Effect of supplemental vitamin E and selenium in high moisture corn diets on the incidence of mulberry heart disease and hepatosis dietetica in pigs. 426 21

Forty-eight weanling S.P.F. Yorshire pigs were used to study the influence of supplemental vitamin E (25 IU per kg of diet) selenium (0.5 ppm in diet) and methionine (0.1% in diet) on the incidence of hepatosis dietetica and mulberry heart disease when fed a torula yeast-corn diet. Vitamin E and/or selenium increased pig survival. Supplemental selenium resulted in increased liver selenium concentrations. No hepatosis dietetica was observed in any of the pigs. The addition of vitamin E and/or selenium at the levels used did not reduce the frequency of myocardial lesions; however, they prevented skeletal muscular dystrophy and exudative diathesis. The myocardial lesions were less severe in supplemented pigs compared with unsupplemented controls.
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PMID:Vitamin E, selenium and methionine supplementation of dystrophogenic diets for pigs. 426 22

This paper discusses the nutritional requirements for fat in infants and children in the light of the dietary alterations recently proposed by the Inter-Society Commission on Heart Disease Resources. It is not well known what the requirement for total fat and for serum cholesterol level during the first year of life should be. It is known that the only proved requirement for fat is linoleic acid, and that a logical fat intake would be that supplied by breast milk. 80% of American infants are fed with formulas which are not supplemented with the essential vitamin E. After infancy fat requirements change, and body stores are sufficient to insure against fatty acid deficiency. The dietary intake of American children is high in quantities of saturated fats and cholesterol, possibly leading to atherosclerosis later in life. The question is whether this cholesterogenic diet is harmful to all Americans or to a limited number of clinically discernible subjects, i.e., those children genetically predisposed to hyperlipoproteinimia. Such predisposition could be diagnosed at birth by screening of the umbilical cord blood, and checked again at school age and at adolescence. Thus, although limitation of a cholesterogenic diet to prevent obesity is reasonable, restricting cholestrogenic foods in everyone for the unproved distant goal of reducing atherosclerosis is dubious.
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PMID:Fat nutrition and diet in childhood. 463 20

Fasting blood samples taken from 116 apparently healthy men aged 30-50 years were assayed for selenium, glutathione peroxidase activity, vitamin E, cadmium, lead, glucose, lipids, and albumin. Blood pressure was measured in each subject, and details of height, weight, smoking habits, and alcohol consumption were recorded. Multivariate analysis of the data showed that the decrease in blood and serum concentrations of selenium and the increase in whole blood cadmium concentrations in the cigarette smokers was independent of alcohol consumption. There was no correlation between blood selenium concentrations or glutathione peroxidase activities and the risk factors for cardiovascular disease. Neither alcohol consumption nor smoking had an effect on the vitamin E concentrations. There was a strong association, however, between vitamin E and serum lipid concentrations, although the increase in triglyceride concentrations in the smokers was not matched by a comparable increase in vitamin E. The possible role of selenium in the aetiology of heart disease remains unresolved.
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PMID:Selenium and vitamin E in relation to risk factors for coronary heart disease. 669 79

Effects of vitamin E, a fat soluble antioxidant, on the isoproterenol-induced changes in the lipid peroxide activity as determined by a quantitation of malondialdehyde (MDA) content in the myocardium were examined. Isoproterenol treatment (80 mg/kg given over two days in two equal doses) caused more than 100 percent increase in the MDA content which was prevented by pretreatment of the animals with vitamin E (alpha-tocopherol acetate, 10 mg/kg) for two weeks. Animals maintained on vitamin E deficient diet for 8 weeks were found to be more sensitive to isoproterenol-induced increase in the MDA content. A small increase in MDA content was also seen due to vitamin E deficiency alone. These changes were found to be reversible upon a 2 week feeding of the animals on the normal diet coupled with vitamin E treatment. Based on these data it is proposed that free radical mediated increase in lipid peroxide activity may have a role in catecholamine-induced heart disease.
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PMID:Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease. 686 78

A better understanding of the functions of ascorbic acid would help clarify the magnitude of the influence of this vitamin on health-related conditions. Many of the purported benefits require confirmation as well as a knowledge of the mechanism of action. The majority of investigations of the association of vitamin C with various types of cancer, with cardiovascular risk, and with cataract formation were epidemiologic studies. Often it was not possible to discern whether the apparent protective effect was due to vitamin C, vitamin E, or carotene, or to a combined effect of these nutrients or of additional factors. Human intervention trials may provide definitive and quantitative assessments of the role of vitamin C in health maintenance. We need to gain a more thorough understanding of the interactions of vitamin C with other nutrients, such as vitamin E and carotenoids, in order to appreciate the role of vitamin C in disease prevention. Investigators are increasingly recognizing the diverse functions of vitamin C in the body in addition to its role in collagen synthesis. However, the functional consequences of these many important roles of vitamin C remain essentially unknown. Excluding scurvy, the health consequences of inadequate vitamin C status are not well characterized. Nonetheless, epidemiologic evidence suggests a role for vitamin C in cancer and heart disease as well as in a number of other diseases.
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PMID:Pharmacology of vitamin C. 794 25


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