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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Only a few years following the introduction of combination oral contraceptives, it was determined that these hormonal preparations led to changes in the glucose and lipid metabolisms, which must be considered as potentially harmful. For example, women with no known disposition to diabetes mellitus may acquire diabetic glucose-overloading with use of oral contraceptives. In addition, the increased occurrence of cardiovascular complications among oral contraceptive users is thought to be directly associated with the effect of lipoprotein displacement. To reduce these effects, a new triphasic combination oral contraceptive, consisting of ethinyl-estradiol and gestodene (15-levonorgestrel), has been introduced. This study specifically investigated the effects of glucose tolerance and lipid metabolism from using this new preparation. 10 women between ages 21-32 (average age 25) participated. All had normal weights and were without known disposition to diabetes mellitus or heart disease. After receiving a medical examination, the women were given the 3-phase pill for 6 months. The pills were administered cyclically according to the usual schedule for oral contraceptives. In each cycle, the dosage consisted of 0.030 mg ethinyl-estradiol (EE) and 0.050 mg gestodene from day 1-6, then 0.400 mg EE and 0.070mg GD from days 7-11, and finally 0.030 mg EE and 0.100 mg GD in the last 10 days. Laboratory tests were done in the luteal phase before the trial's start, and before the final 10 days of the trial in the 2nd and 6th cycle. Fasting levels of plasma glucose and insulin were monitored. Though there are as yet no publications which deal with the influence of gestodene on glucose tolerance, the results from the present study indicate that gestodene in this 3-phase pill does not alter glucose tolerance in women with normal health. The raised AVC value for insulin, which was observed 6 months after treatment, may however indicate that he glucose homeostasis during treatment was maintained due to raised endogenous insulin secretion. It is therefore possible that individuals with latent insulin deficiency might acquire diabetic glucose tolerance because of an inability to show adequate insulin response.
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PMID:[Hormonal contraception with ethinylestradiol and gestoden. The effects on glucose tolerance and lipid metabolism]. 311 Oct 56

Strokes (AVC) represent the 1st cause of death in the department of neurology of Dakar. The main characteristic of stroke is the brutality of the method of formation of neurological deficit. The vascular territory in question amends the clinical expression. Besides the motor deficit stroke can cause neuropsychological disorders affecting language, memory, activity gesture, recognition of oneself and its environment, space and extra corporeal body with the result intellectual deterioration. The mechanisms of stroke are dominated by atherosclerosis and embolic heart disease for ischemic stroke and hypertension and ruptures of vascular malformations for hemorrhagic stroke. CT scan remains the key consideration in determining the nature ischemic or hemorrhagic stroke. Because of its acuteness and rapid progress to irreversible injury stroke is a dramatically high priority medical emergency. The therapeutic strategy should follow a pattern efficient and fast leading to a specific care, gradual and coordinated by the 3rd hour. There is a need to recognize stroke, what is the nature (ischemic, hemorrhagic) and the cause, in order to consider a therapeutic care consistent. The care must start at the very beginning of the stroke and continued during transportation. In the acute phase of stroke, lower blood pressure should be gradual and it is recommended to respect an HTA in the order of 180/105 mm HG except under certain conditions (acute lung oedema, aortic dissection, infarction acute myocardial) that requires a rapid stabilization of blood pressure. Thrombolysis using alteplase (rt-PA) is called in neurovasalar units in case of stroke seen before the 3rd hour and in the absence of contraindications. Anticoagulants are shown in prevention of recurrence of stroke in the embolic heart disease with high risk of recidivism, in the carotid stenosis or vertebral basilar tight with hemodynamic impact downstream and in the extensive thrombosis. The treatment antiplatelet medication is indicated in other cases. The screening and the control of risk factors for vascular constitute an effective weapon for primary prevention. The rehabilitation motor, speech and language and occupational therapy can improve rehabilitation for patients. The prognosis vital and functional depend partly in the early and appropriate management of stroke and also in increasing of education and awareness of population and health care personnel and especially on the diffusion of the means of prevention primary
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PMID:[The management of cerebrovascular events]. 1910 12

Children's heart diseases in Africa represent a public health problem that is difficult to cope with due to young population density, low socioeconomic status and lack of suitable technical platforms. This study aims to highlight the echocardiographic and therapeutic aspects of cardiopathies in children hospitalized at the pediatric department of the University Hospital Souro Sanou, Bobo-Dioulasso. We conducted a descriptive cross-sectional study over the period January 2013-December 2014 (24 months). It was based on a literature review of echocardiography reports performed on children under 15 years of age in the echocardiography laboratory of CHUSS and of medical records of their therapeutic follow-up. During the study period, 184 echocardiographic examinations were performed and allowed identification of 93 cases of children with heart disease (50.50% of cases). Among them, 71% (66/93) of cases with congenital cardiopathies were distinguished and 29% (27/93) of acquired cardiopathies. The most common congenital heart diseases were: IVC (27.2%), IAC (10.6%), AVC (7.5%), F4T (9.1%), CAT (6%), related forms ( 15%). Acquired heart diseases were dominated by rheumatic valve diseases (48%), hypokinetic dilated cardiomyopathy (33.3%) and pericardial tamponade (18.5%). Surgery was recommended in 53.7% (50/93) of cases, of whom 86% (43/50) with congenital heart diseases and 14% (7/50) with acquired heart diseases. 21% (9/43) of patients with congenital heart diseases underwent cardiac surgery. No acquired heart disease requiring surgery was surgically treated. Cardiopathies in children are frequent in Bobo-Dioulasso. Multidisciplinary strategies associated with resource optimization should improve the management of these cardiopathies.
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PMID:[Cardiopathies in children hospitalized at the University hospital Souro Sanou, Bobo-Dioulasso: echocardiographic and therapeutic aspects]. 2825 Aug 86