Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ortner's syndrome results in hoarseness caused by compression of the left laryngeal recurrent as a result of cardiovascular pathology. A wide range of cardiovascular such as valvular heart disease, thoracic aortic aneurysm and congenital heart disease may result in Ortner's syndrome. We present a case of Ortner's syndrome caused by a large diameter (120 mm) aneurysm, previously unreported in the literature. A male patient aged 71 years was admitted to our clinic for exertional dyspnea, asthenia and hoarseness. In the indirect laryngoscopic examination, left vocal cord paralysis of the patient was observed and his chest X-ray revealed a mass with a diameter of 120 mm that filled the left upper zone. A dissected aortic aneurysm 120 mm in diameter in arcus level at thorax was seen in CT imaging. Surgical treatment was suggested; however, the patient refused treatment and died at the 4th month of the follow up period.
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PMID:[Ortner's syndrome caused by dissecting aortic aneurysm]. 2370 58

We present a case of a 67-year-old man who was an active smoker, with a clinical history of ischaemic cardiopathy, hypertension, who presented to the emergency room with hoarseness of voice of 2 weeks duration. No other neurological or cardiorespiratory symptoms were found. Physical examination revealed an aortic regurgitation murmur with radial pulse difference between the upper limbs and femoral pulse difference on lower limbs. Laryngoscopy examination revealed a left vocal cord paralysis in the paramedian position, without signs of malignancy. Thoracoabdominal CT angiography was performed to rule out an aortic dissection. CT revealed a dissection in the descending thoracic aortic arch and abdominal aorta. Cardiovascular surgery was consulted and decided to place endoprosthesis at the thoracic and abdominal aortic area. Hoarseness eventually resolved during the following weeks. Ortner's syndrome is described as hoarseness of voice caused by compression of the left recurrent laryngeal nerve of cardiovascular origin.
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PMID:Ortner's syndrome: a case report and review of the literature. 2503 42

Ortner's syndrome is a rare condition characterized by hoarseness of voice due to left recurrent laryngeal nerve (RLN) palsy in association with cardiovascular disease. We report two cases of congenital heart disease in infants presenting with Ortner's syndrome. We believe that the dilated pulmonary artery in the first case and the left atrial dilatation in the second case caused compression of the left RLN resulting in hoarseness of voice. After the corrective cardiac surgery, the voice of both the infants had normalized. Through this case report, we highlight that Ortner's syndrome is an important differential diagnosis of hoarseness of voice in infancy.
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PMID:Ortner's Syndrome as a Presenting Feature of Congenital Heart Disease in Infants. 3301 6