Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Use of digitalis declined in the 1970s, especially among younger physicians, but several recent studies have conclusively documented the hemodynamic and symptomatic benefits of digitalis in patients with class III and IV heart failure resulting from left ventricular systolic dysfunction. The S3 gallop is a useful marker for a subset with a highly favorable response. Symptomatic benefit cannot be shown in most patients with class I and II heart disease (e.g., most myocardial infarction patients). When patients are monitored carefully for evidence of toxicity with serum digitalis assays and for factors that may affect drug bioavailability or clearance, digitalis is well tolerated.
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PMID:Digitalis: a drug that refuses to die. 215 59

In a prospective study of 1012 patients above the age of 12 years, we detected 4 (0.4%) cases of left ventricular false tendon (LVFT) by echocardiography. Two patients had significant heart disease and LVFT was perhaps a chance occurrence; two others had no significant heart disease and LVFT probably had a causal association with S3 gallop in one and systolic murmur in the other. Diagnosis of LVFT may help to explain cardiac findings of uncertain origin.
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PMID:Left ventricular false tendons: echocardiographic incidence in India and clinical importance. 620 18

Ventricular gallop is a reliable indicator of poor ventricular compliance and heart failure in the elderly. Late diastolic atrial gallop, however, has very little use in the diagnosis of heart disease in the elderly. M-mode and 2-dimensional echocardiography are the most expeditious and least costly of the non-invasive means of identifying the cause of heart failure in the elderly. They enable rapid assessment of cardiac chamber size, wall thickness and contractility, valve morphology and motion, and easy evaluation of the pericardium.
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PMID:Congestive heart failure: Dx and Rx in the elderly. 648 61

To determine which of the many clinical parameters routinely collected influence mortality in patients with low left ventricular ejection fraction (LVEF) (< 45% at radionuclide ventriculography), 128 elderly patients (mean age 79 +/- 3 years) with various heart diseases were prospectively followed for 3 years. Twenty-eight-percent had coronary heart disease, 16% hypertensive heart disease, 7% valvular heart disease. The remaining 62 patients (48%) made up a group comprising patients with primitive cardiomyopathy, cor pulmonary with no evidence of coronary heart disease, valvular disease or hypertensive heart disease. Thirty-four-percent of all patients were classified as having congestive heart failure (CHF). Age, sex and 37 clinical variables were analyzed using a Cox proportional model. Forty-four patients died, 36 (82%) of sudden cardiac death. Ten characteristics at study entry predicted an increased mortality risk: S3 gallop, number of clinical signs >or= 3, LVEF <or= 25%, New York Heart Association (NYHA) class >or= III, dyspnea, digoxin treatment, rales, number of symptoms >or= 4, asthenia, associated pulmonary disease. Long-term survival of very elderly patients with low ejection fraction is related to the functional capacity, the severity of symptoms and the number of clinical signs. Moreover a LVEF <or= 25% selects a subgroup of patients at higher risk. Our results suggest that these variables may influence the long-term survival of elderly patients with heart disease. Further studies with a greater number of patients are necessary to better delineate the prognostic value of the clinical and instrumental variables routinely collected in these patients.
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PMID:Clinical determinants of long-term mortality in elderly patients with heart disease. 1537 99