Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systolic heart failure because of hyperthyroidism in patients without preexisting heart disease is not common. Thyrotoxic systolic heart failure is rarely diagnosed during life. Reports about thyrotoxicosis-related systolic heart failure have been diagnosed postmortem. However, antemortem diagnosis of this fatal disease has important clinical implications because if detected early, thyrotoxicosis-related systolic heart failure is reversible. Here is a report a patient with Graves' disease, systolic heart failure, and deep jaundice, which resolved after the treatment of antithyroid drugs.
 ...
PMID:Case report: reversible systolic heart failure and deep jaundice in hyperthyroidism. 890 Mar 90

The final outcome of many forms of heart disease is congestive heart failure (CHF), a condition in which the heart can no longer pump enough blood to fulfill the body's metabolic requirements. Systolic heart failure is characterized by an impairment of myocardial contractility, whereas diastolic heart failure results from the left ventricle's inability to distend normally. The general features of CHF include pressure or volume overload, muscle loss, decreased myocardial contractility, or restrictive filling. Treatment is palliative, and 50% of the patients with CHF can be expected to die within 5 years; the mortality is much higher in those with coronary disease or limiting symptoms. The following signs are associated with a particularly poor prognosis: age > 55 years, cardiomegaly, a cardiac index of < 3, a left-ventricular end-diastolic pressure of > 20 mmHg, an ejection fraction of < 30%, a thin ventricular wall, dyspnea, and evidence of atrial fibrillation or ventricular tachycardia. Because of their high mortality, many of these patients eventually become candidates for cardiac transplantation.
 ...
PMID:The pathogenesis and prognosis of end-stage heart disease. 1522 88