Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Correlational and contingency analytical techniques were used to investigate the relationship between subtest scores on the Minnesota Multiphasic Personality Inventory (MMPI) and coronary heart disease (CHD) risk factors in 1000 submariners. Groups of personality traits, both enhancing and protecting against risk of heart disease, were identified in these subjects. Personality trait patterns tending to be least associated with cardiovascular risk are tentatively identified by the three MMPI scales: psychasthenia, schizophrenia, and social introversion. On the other hand, the scales most strongly related to CHD risk in the submariner sample were denial of symptoms as measured by the K-scale, hypochondriasis, and hysteria. While the inherent inaccuracy in the prediction of CHD risk in young healty individuals limits generalization from these findings, the potential utility of the MMPI to assist in risk detection is indicated. Comparisons of cigarette smoking, coffee drinking, and alcohol consumption with personality characteristics identified by the MMPI yielded trait clusters associated with each addictive habit. Cigarette smoking and alcohol consumption tended to correlate with traits positively associated with CHD risk. The correlations between those addictive habits and MMPI subtest scores were most significant for the F-scale, which measures inordinate tendencies to exaggerated emotional symptoms, and for the psychopathic deviate and hypomania scales. Significant negative correlations were found between the amount of coffee consumed and those personality traits negatively associated wit CHD risk. These negative relationships were most significant for the MMPI scales schizophrenia and psychasthenia. Though the relationships were not necessarily construed to be causal, the contrasting modes through which these drug-associated habits appeared to relate to cardiovascular risk lend some support to the assumption that individuals with various specific sets of personality characteristics tend to incorporate these additive behaviors into their behavior repertoire in very different ways.
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PMID:Relationship of personality factors and some social habits to cardiovascular risk in submariners. 708 56

The Minnesota Multiphasic Personality Inventory (MMPI-2) is commonly used in chronic illness and chronic pain populations to assess psychological functioning. We report the results of the first study employing the MMPI-2 to assess psychological aspects of patients with Gaucher disease, type I (GD) is an inborn error of metabolism with unique features as a chronic illness: the disorder often presents with mild symptoms, and is frequently diagnosed in later childhood or adulthood; the treatment is highly efficacious, but, that same treatment is intrusive and expensive and requires that patients restructure their work and personal schedules. In this study, 28 patients with GD completed the MMPI-2 and a background questionnaire. GD patients scored significantly higher than the MMPI-2 normative sample on MMPI-2 scales of Validity (K), Hypochondriasis (Hs), Depression (D), Hysteria (Hy), Psychasthenia (Pt) and Schizophrenia (Sc). Individuals with elevated scores on the Hs, D and Hy scales tend to have somatic concerns and depressed mood. Under stress, they are likely to report physical symptoms. Elevated Pt and Sc scales suggest psychological turmoil and, possibly feelings of isolation. An elevated K scale indicates a tendency for individuals to deny psychopathology. The length of time the patient with GD had been on enzyme replacement therapy was not significantly related to any of the 13 MMPI-2 scales. Cohorts of patients with chronic heart disease (CRHD) and cohorts of patients with chronic pain were utilized as comparative populations in this investigation. The elevated scores of the GD patients on MMPI-2 scales Hs, D and Hy were similar to those of the CRHD population. The chronic pain patients also showed elevations on MMPI-2 scales Hs, D and Hy, which were elevated in the GD patients; the elevations in the chronic pain patients were higher than those shown by the GD patients. We conclude that patients with GD exhibit moderate to severe psychological complications, similar to patients with other long-term chronic illnesses.
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PMID:Psychological complications of patients with Gaucher disease. 1660 75