Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cardiovascular diseases are the most common causes of morbidity and mortality in individuals with peripheral vascular disease (PVD). Among patients who have undergone lower extremity amputation as a result of PVD, the prevalence of concomitant cardiovascular disease may be as high as 75%. Comorbid heart disease may complicate the postamputation course of recovery, delay initiation of rehabilitation training, and inhibit the achievement of maximal functional independence. A variety of methods have been used to assess cardiac status and risk in amputation patients undergoing physical training; these have included clinical evaluation, resting electrocardiography, and continuous dynamic electrocardiography during either standard physical therapy exercise or adapted ergometry. Several conditioning training programs have been developed to improve the cardiovascular fitness of patients with dysvascular amputation, the results of which have been favorable. These assessment and intervention strategies have extensive applicability in the clinical management of patients with dysvascular amputation.
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PMID:Cardiovascular disease in patients with dysvascular amputation. 947 5

We reviewed the approach to preoperative cardiac risk assessment, incorporating new information regarding the pathophysiologic features of perioperative myocardial ischemia and recent clinical trials. Relevant articles were identified from a MEDLINE search, followed by bibliography review of the articles identified. The multifactorial risk indexes are valuable in stratifying risks among unselected patients undergoing noncardiac surgery, but they underestimate the risks in selected groups, particularly patients with peripheral vascular disease. The preoperative evaluation of patients with coronary artery disease and risk reduction strategies for high-risk patients are considered. There are no prospective randomized clinical data comparing preoperative revascularization to intensive medical therapy and clinical decisions must be individualized. Risks particular to patients with congestive heart failure and valvular heart disease are also reviewed. Patients with congestive heart failure can undergo noncardiac surgery safely, if their cardiac disease is well-compensated. Patients with aortic stenosis have high risks, and management strategies include valve replacement, aortic valvuloplasty, and aggressive medical treatment. These modalities have not been compared prospectively, and clinical decisions must be individualized. Preoperative arrhythmias are important risk factors, although they appear to confer risk only when due to underlying heart disease. A thorough, targeted history and physical examination supplemented with judicious laboratory studies are usually sufficient to assess a patient's risk for upcoming noncardiac surgery. The clinical history should identify risk factors that predict cardiac complications, and special attention should be given to those risk factors that can be modified before surgery. New developments in perioperative medicine will likely lead to postoperative interventions to reduce silent myocardial ischemia and clinical complications.
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PMID:Preoperative cardiac evaluation for elective noncardiac surgery. 951 22

We present our experience of 15 patients operated on by lumbar sympathectomies between 1987-1993, to confirm the effective and permanent efficacy of sympathectomy in peripheral vascular disease of the lower limbs. The patients, 9 men and 6 women (age 58-86) presented with rest pain (12), and minimal toe lesions (3). After an eco color-Doppler and angiography of the lower limbs, a radical operative sympathectomy (L2-L5) was performed in all patients. Associated diseases were: ischemic cardiopathy (61.7%), renal failure (25%), diabetic disease (61.7%), carotid stenosis (25%), abdominal aortic aneurysm (12%). In four patients, was performed during the same surgical time, 2 abdominal aortic aneurysm repairs, and 2 aorto-bifemoral bypasses. No patients died, operative morbidity was 12.5% (2 cases). The clinical and instrumental follow-up performed on 6 patients (38.3%) after 3 years, demonstrated in all cases the regression of the rest pain (12 patients) and the healing of the toe lesions (3 diabetic patients). Our results confirm the efficacy of sympathectomy especially when performed in young patients. The small number of diabetic patients in our study made statistical evaluation difficult, but it is generally considered that the results are worse in diabetic patients, because the microvascular lesions in these patients reduce peripheral vasodilatation.
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PMID:[Long-term results of radical lumbar ganglionectomy. Our experience]. 961 14

Gallbladder perforation is a frequent complication of acute acalculous cholecystitis (AAC), resulting in substantially increased morbidity and mortality. Two groups of patients are at increased risk for perforation: those with systemic diseases (especially peripheral vascular disease, intrinsic heart disease, or diabetes) and those who are chronically immunosuppressed. The current population of solid organ transplant recipients meets both criteria. We describe an unusual case of gallbladder perforation as a complication of AAC in an otherwise healthy kidney transplant recipient. Because transplant recipients are at increased risk for gallbladder perforation, maintaining a high index of suspicion for this complication will help avoid the increased morbidity and mortality associated with this diagnosis.
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PMID:Acute acalculous cholecystitis (AAC) resulting in gallbladder perforation in a solid organ transplant recipient: a case report. 964 24

Smoking--once a socially accepted behavior--is the leading preventable cause of death and disability in the United States. During the first decades of the 20th century, lung cancer was rare; however, as cigarette smoking became increasingly popular, first among men and later among women, the incidence of lung cancer became epidemic (Figure 1). In 1930, the lung cancer death rate for men was 4.9 per 100,000; in 1990, the rate had increased to 75.6 per 100,000 (1). Other diseases and conditions now known to be caused by tobacco use include heart disease, atherosclerotic peripheral vascular disease, laryngeal cancer, oral cancer, esophageal cancer, chronic obstructive pulmonary disease, intrauterine growth retardation, and low birthweight. During the latter part of the 20th century, the adverse health effects from exposure to environmental tobacco smoke also were documented. These include lung cancer, asthma, respiratory infections, and decreased pulmonary function (2).
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PMID:Tobacco use--United States, 1900-1999. 1057 92

This community nonrandomized study comprised a consecutive cohort of 1,545 (81% males) < or = 65-year-old patients who survived a first acute myocardial infarction (AMI). The all-cause 4- to 5-year mortality rate was 9% (80% cardiac). Univariate analysis revealed that older age, female gender, hypertension, diabetes, not undergoing thrombolysis, higher Killip class, preinfarction heart disease, peripheral vascular disease (PVD) and chronic obstructive lung disease (COLD) were significantly associated with increased mortality. Multivariate analyses disclosed the latter five parameters as being independent predictors of mortality. Our results show that patients undergoing thrombolysis enjoyed a progressive prognostic benefit over time. The independent contribution of PVD and COLD to long-term mortality is highlighted, in addition to the contribution of thrombolytic therapy, Killip class, and heart disease prior to infarction as being important predictors of long-term mortality in patients with a first AMI.
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PMID:Long-term mortality rates reflect progressive prognostic benefits of thrombolysis in patients with first acute myocardial infarction. 1117 83

The purpose of this study was to determine whether a difference exists between genders in compliance to a heart-healthy lifestyle and whether the stress of coronary artery bypass graft (CABG) surgery caused one of the genders to become more compliant. A convenience sample of 30 men and 30 women who had CABG surgery at least 1 year earlier and were enrolled in a follow-up program through a cardiovascular surgeon's office were interviewed to assess coronary artery disease risk. The instrument used was the RISKO Heart Hazard Appraisal Tool. Preoperative records were also reviewed with the same tool to assess a person's preoperative risk. The research design used was 2 x 2 repeated measures. Data were analyzed with 2 x 2 repeated measures analysis of variance (ANOVA). Two findings were discovered. First, a statistically significant difference exists between men and women (F = 5.82 P =.019), with men scoring lower RISKO scores than women, indicating lower cardiovascular risk and better compliance to a healthy lifestyle, both before and after surgery. Second, a significant difference exists between preoperative and postoperative RISKO scores in the total population (F = 8.77 P =.004). Postoperative RISKO scores were lower, indicating an improvement in cardiovascular risk. The risk factors assessed are applicable to both heart disease and peripheral vascular disease.
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PMID:Differences between men and women in compliance with risk factor reduction: before and after coronary artery bypass surgery. 1153 79

Newer, minimally invasive catheter-based endovascular technology utilizing stent grafts are currently being evaluated for abdominal aortic aneurysm (AAA) repair. A retrospective review of all (3 years) consecutive, non-ruptured elective AAA repairs was undertaken to document the results of AAA surgical repair in a modern cohort of patients to allow a contemporary comparison with the evolving endoluminal data. One hundred twenty-one AAAs were identified in a male veteran population. Mean age was 68.5 +/-7.7 years. Medical history review showed hypertension in 55%, heart disease in 73.5%, peripheral vascular disease in 21%, stroke and transient ischemic attacks in 22%, diabetes mellitus in 7%, renal insufficiency in 10%, and smoking history in 80%. The AAA size was documented with ultrasound (5.2 +/-1.3 cm, n=40) and computed tomography (5.6 +/-1.3 cm, n=100). Fifty-nine percent had angiography. Intraoperative end points included an operative time of 165 +/-6.3 minutes from incision to dressing placement. A Dacron tube graft was used in 78%, the remaining were Dacron bifurcated grafts. A suprarenal clamp was used in 8% for proximal aortic control with juxtarenal aneurysms. A pulmonary-artery catheter was placed in 69%. A transverse incision was used in 69% of patients and a midline incision was used in the rest. Estimated blood loss was 1505 +/-103 mL; cell saver blood returned 754 +/-53 mL; crystalloid/Hespan 4771 +/-176 mL; banked packed red blood cells 0.75 +/-0.11 U. Time to extubation was, in the operating room (78.5%), on the day of the operation (5.0%), postoperative day (POD) 1 (12.4%), POD2 (1.7%), POD3 (0.8%), and one case was performed with epidural anesthesia only. Postoperative end points included a 30-day mortality rate of 1.6% (two patients). Postoperative morbidity included wound dehiscence 0.8%; sepsis, urinary tract infection, wound infection, leg ischemia, ischemic colitis, and stroke each had an incidence of 1.6%; myocardial infarction, congestive heart failure, pneumonia, re-operation for suspected bleeding, and ileus or bowel obstruction occurred with an incidence of 3.3%. No significant increase in serum creatinine levels was noted. Time to enteral fluids/nutrition was 3.5 +/-0.08 days. Patients were out of bed to a chair or walking by 1.3 +/-0.06 days postoperatively. The length of stay in the intensive care unit (ICU) was 2.0 +/-0.12 days and postoperative hospital stay was 6.6 +/- 0.33 days. Transfusion requirement for the hospital stay was 1.6 +/-0.2 U per patient. This review highlights a cohort of male veteran patients with significant cardiac co-morbidity who have undergone repair with a conventional open technique and low mortality and morbidity rates. This group had rapid extubation, time to oral intake, and ambulation. In addition, ICU and hospital stays were relatively short.
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PMID:Abdominal aortic aneurysm repair. 1156 37

The objective of this report was to analyze the current surgical results of operative treatment in patients suffering ruptured AAA (abdominal aortic aneurysms) and to define those independent predictive factors for mortality. During a period of 2 years, from January 1996 to December 1997, 144 patients operated on for ruptured AAA in 10 hospitals were included in a multicenter retrospective study. Among the collected variables concerning each patient, those with potential relation to surgical mortality were studied: gender, age, diabetes, hypertension, cardiopathy, pulmonary obstructive disease, preoperative renal dysfunction, symptomatic cerebrovascular disease, peripheral vascular disease, hematocrit on admission, preoperative hypotension < 80 mmHg, loss of consciousness, cardiac arrest, aortic aneurysm location (infrarenal versus non-infrarenal), iliac involvement, aneurysm size, type of rupture, left renal vein ligature, ligature of a patent inferior mesenteric artery, place of aortic cross-clamping, type of grafting, exclusion of both hypogastric arteries, venous technical complications, associated surgery, use of cell saver, intraoperative blood loss, and postoperative complications (renal failure, sepsis, coagulopathy, cardiac complications, pulmonary complications, colon ischemia, prosthetic graft complications, and need for reoperation). Those variables with statistical significance in the univariate analysis were introduced into a multivariate logistic regression model to determine the independent predictors of death. From our results we concluded that surgery for ruptured abdominal aortic aneurysms continues to have an excessively high mortality rate. Even though some preoperative variables could be identified as predictors of mortality, an absolute mortality risk has not yet been determined and the decision to negate surgery should be individualized rather than taken on that basis only. Early diagnosis and treatment of symptomatic aneurysms would improve mortality figures and selective screening should be contemplated.
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PMID:Factors increasing the mortality rate for patients with ruptured abdominal aortic aneurysms. 1176 39

The Uruguayan Dialysis Registry (UDR) is an obligatory registry and includes all the patients on dialysis treatment in the country. The dialysis prevalence rate at 12-31-1997 was 604 pmp and the mortality rate in 1997 was 132 deaths per 1,000 patient years at risk. Adjusted mortality of each dialysis center in the country (n = 35) is calculated every year. In this paper, mortality in the different centers was compared applying the usual methodology in order to identify centers with higher mortality and the importance of comorbidity m the mortality comparison among centers was analyzed. 1. The prevalent and incident population of the 1992-1996 period was considered (n 2989). The mortality rate of each dialysis center, adjusted for age and nephropathy by indirect standardization, was calculated. The prevalent and incident population (1985-1991) of the UDR was used as standard. Standardized mortality rate (SMR) for each center and for the total population was obtained dividing observed deaths by expected deaths. 2. The prevalent population at january 1, 1994 was considered (n 1131) and the observation period was extended from january 1, 1994 to december 31, 1997. Demographic and co-morbidity data were collected at the start of the observation period. Multivariate analysis of survival was applied to identify significant risk factors (Cox hazard regression model). The mortality rate of each dialysis center was adjusted for the significant risk factors. Seven centers had significant higher mortality rate adjusted for age and nephropathy than the average of the standard population. Four year survival in the 7 centers (51.6%) was lower than in the other 28 centers (63.6%) (p = 0.0001). In the multivariate analysis, 5 variables (age, diabetes, arteriosclerotic heart disease, cerebrovascular disease and peripheral vascular disease) were significantly related with mortality. The relative risk of death, adjusted for the five significant risk factors showed higher significant mortality only in four centers. Three centers did not show mortality differences with the other centers when mortality was analyzed in the multivariate analysis with the significant risk factors. We concluded that adjusting the mortality rate to the significant risk factors allow to discriminate if the differences observed among centers are related or not to an unequal distribution of the risk factors.
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PMID:[Significance of comorbidity in the control of the quality of treatment of dialysis patients]. 1179 16


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