Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of deaths by cause, race, and sex among 2,709 workers (1,003 white males, 789 black males, 517 white females, and 400 black females) in the tobacco industry identified from obituary listings of the Tobacco Workers' International Union from 1957 to 1978 were compared to expected numbers based on the experience of the U.S. population. The frequency of deaths from cancer of the colon was slightly elevated among each race-sex group [proportionate mortality ratios (PMRs) from 129 to 163]. Although unexplained, this resembles the excess of cancer of the digestive system previously reported among cigarette manufacturers. The excess deaths from cancer of the lung occurred only among white females and may represent chance findings. Among non-neoplastic causes of death, PMRs for arteriosclerotic heart disease, motor vehicle accidents, and suicides were high among most race-sex groups, while PMRs for respiratory disease and cirrhosis of the liver were low.
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PMID:Causes of death among workers in the tobacco industry. 661 3

Accurate prevalence and incidence figures do not exist on a global basis, yet available data suggest that acute respiratory infections in children represent a problem of enormous magnitude. World Health Organization (WHO) data from 88 countries representing 1/4 of the world's population indicate that there are over 666,000 deaths annual from acute respiratory infections. Assuming that nonreporting countries have similar mortality rates, it can be calculated that there are at least 2.2 million deaths from acute respiratory infections throughout the world each year. Despite the enormity of the problem, relatively little is known about the factors that contribute to these deaths in children or adults, or about the extent to which they are due to unusual severity of the disease, lack of access to the health care system, and institutional or social factors. The causative agents are unknown. More knowledge is needed to mount an effective program for the prevention and treatment of acute respiratory infections. In Costa Rica mortality from this disease is 12 times higher in malnourished infants than in those of normal weight. Data from Papua, New Guinea indicate that Streptococcus pneumoniae and Hemophilus influenzae are common etiologic agents. More data of this kind are needed from different countries. Also needed is information on the availability and use of adequate medical care. People in developed countries run a greater risk of dying from lung cancer and cardiovascular diseases than do people in developing countries, but the chances of dying from acute respiratory infections generally exceed those of dying from lung cancer or cardiovascular disease in the developing countries. When evaluating the seriousness of a public health problem it is important to consider the number of years of life that have been lost as well as morbidity and mortality. If there are 2.2 million deaths in the world from acute respiratory infections in children under the age of 1 year, then each year there are almost 200 million death years lost because of acute respiratory infections in the world. Thus, on a global scale acute respiratory infections represent a public health problem of greater magnitude than either heart disease or cancer. The fact that the annual WHO budget for heart disease is at least 50 times higher than the budget for all forms of respiratory disease represents seriously misplaced priorities. Properly organized research programs into the etiologic agents involved in acute respiratory infection, together with data collection on other contributing factors, are required so that effective prevention and treatment programs can be initiated.
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PMID:Acute respiratory infections in children. A global public-health problem. 670 Jun 93

Four dynamic tests of cardiac function were compared in a group of 13 long-standing insulin-dependent diabetics who had no clinical evidence of cardio-respiratory disease. One patient developed abnormal features during 24 hour ambulatory electrocardiograms while all 13 patients had normal exercise electrocardiograms. The change in left ventricular ejection fraction during dynamic supine exercise as measured by gated blood-pool scintigraphy was not significantly different from control subjects (p less than 0.1) while during cold stimulation testing the change in left ventricular ejection fraction in the diabetics was highly significantly different from the control subjects (p less than 0.01). Five of the patients had one or more abnormal tests of autonomic function. The cold stimulation test may be a sensitive index of cardiac dysfunction in diabetics but as the mechanism is unclear alternative explanations are possible. While the etiology of heart disease in such patients is uncertain it is likely to be multifactorial and this test may prove useful in investigating the natural history and pathogenesis of cardiac disease in diabetics.
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PMID:Cardiac function during stress testing in long-standing insulin-dependent diabetics. 688 May 65

The long-term mortality experience of California agricultural workers who filed workers' compensation claims for respiratory diseases, pesticide illnesses, and injuries between 1946 and 1975 was observed until 1991 and compared to U.S. death rates. The respiratory disease claimants had an elevated relative risk of 3.27 (95% CI 2.09-4.86) for mortality from nonmalignant respiratory diseases (NMRD). Emphysema mortality was particularly high, with a relative risk of 5.94 (95% CI 2.56-11.70). NMRD mortality peaked 5 to 9 years after the claims were filed (relative risk 9.83, 95% CI 4.47-18.57) and was most strongly associated with exposure to wood, rice, coffee, and flour dusts. Among the pesticide illness claimants, mortality from heart disease was slightly elevated in the subcohort with systemic pesticide illness (SMR = 1.32, 95% CI 0.86-1.94). Among the injury claimants, risk was increased for motor vehicle deaths (relative risk 1.62, 95% CI 0.74-3.08). It was concluded that respiratory disease claimants in agriculture have a significantly elevated risk of mortality from respiratory diseases and that the risk is highest (10-fold) 5-9 years after claims are filed.
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PMID:Mortality in agricultural workers after compensation claims for respiratory disease, pesticide illness, and injury. 765 57

From 1983 to 1989, 96 oesophagectomies (30% of all oesophagectomies performed during this period) were performed without thoracotomy and then analyzed retrospectively. Most were performed due to contraindications including age (17%), respiratory disease (47%), heart disease (37%) or for superficial oesophageal lesions (35% were stage T1). Operative mortality was 3.1%. Fistulization of the anastomosis occurred in 7.5% of the cases. Actuarial survival rate at 5 years was 29% and was independent of age but dependent on localization, the size of the tumour, presence of parietal invasion and TNM classification. However, patient selection introduced bias and a prospective randomized study comparing oesophagectomy without thoracotomy and oesophagectomy via right thoracotomy and midline incision demonstrated that mortality and complications were similar with the two techniques. Long term survival was not dependent on access route, but on the stage of the disease.
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PMID:[Esophagectomy without thoracotomy. Comparison between a retrospective study and a prospective randomized trial]. 773 44

Pulmonary arterial hypertension (PAHT) is defined by an increase in mean pulmonary artery pressure above 20 mmHg. Its diagnosis is often easy by cardiac echo-Doppler. Hemodynamic investigation is required in non-echogenic patients or in order to define the type of PAHT: pre- or post-capillary. It is important to determine, on the basis of non-invasive clinical and paraclinical (echocardiography) studies, those patients in whom catheterisation is indicated. PAHT may be due to chronic respiratory disease, left heart disorders, congenital heart disease or follow pulmonary embolism. It is sometimes apparently primary. The prognosis of PAHT depends upon its etiology: when PAHT is secondary to heart disease, it reflects worsening of the causative cardiac problem, which must be corrected. PAHT is a prognostic factor in chronic obstructive lung disease. The course is particularly grave in primary PAHT.
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PMID:[Diagnosis, course and prognosis of pulmonary arterial hypertension]. 782 53

The "Health Transition" describes the medical consequences which accompany the demographic transition and development. In many Asian countries, as the infectious diseases of infancy decline, such as diarrhea, acute respiratory disease, measles and malaria, so too, do infant mortality rates. As a consequence of falling infant mortality rates and declines in fertility, the age pyramid has become more rectangular. No longer is nearly half of the population under the age of 15 years. Diseases of adults are beginning to become predominant: trauma, heart disease, cancer, stroke and diabetes. Life expectancy has increased along with costs of the health care system. As a fraction of per capita gross domestic product, health care is beginning to become a major national expense. It is ironic that the one vector-borne infectious disease likely to bridge the health transition in tropical countries is dengue. As evidenced by the experience of Singapore and Taiwan, modern housing and commercial development provide more, rather than fewer breeding places for Aedes aegypti. Greater affluence often means less compliance with mosquito control programs. Meanwhile, the dengue viruses, heeding some unknown genetic imperative, cause ever more severe disease. Modern Asian societies must count dengue as a real and enduring threat. To prevent costly hospitalizations and a sense of social disorder, effective measures must be adopted to achieve a significant reduction of Aedes aegypti populations. Sustained dengue control requires source reduction which, in turn depends upon imaginative leadership, skilled man power, legislative authority, an authentic national research program and intersectoral cooperation. A leadership role beckons for new actors in the control of Aedes aegypti: large municipalities, environmental agencies and the private sector.
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PMID:Dengue in the health transition. 784 46

This study was designed for the purpose of investigating the factors for longevity in the Tokyo metropolitan area. At first, we examined the social and physical background of centenarians by direct mail in 1992. A total of 398 questionnaires (from 81 males and 308 females) were returned. There was a significant gender difference in mobility, with 38% of males and 10% of females being able to take a walk. However 19% of male centenarians and 28% of female ones were bedridden. Hypertension, respiratory disease and heart disease were found in 22%, 16%, 16%, without any significant gender differences. On the contrary, there were more female centenarians with past histories of bone fracture (34%) than male (10%). This discrepancy suggest that bone fracture may be one of the factors causing the gender differences in mobility. Those who had a high level of education were more frequent in centenarians (27% of males and 8% of females) than in the general population of their contemporaries in Japan (less than 2%). The average age at death of the centenarians' parents was 69.6 +/- 15.7 y/o for their father and 71.2 +/- 17.2 y/o for their mother. These ages were significantly higher than the average life-span in the last decade of the 19th century, according to the First Life Tables in Japan. The possibility is suggested that longevity was inherited in these centenarians' families.
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PMID:[Direct mail investigation of the social and physical background of centenarians in Tokyo metropolitan area]. 807 9

A cohort of some 11,000 men born 1891-1920 and employed for at least one month in the chrysotile mines and mills of Quebec, was established in 1966 and has been followed ever since. Of the 5351 men surviving into 1976, only 16 could not be traced; 2508 were still alive in 1989, and 2827 had died; by the end of 1992 a further 698 were known to have died, giving an overall mortality of almost 80%. This paper presents the results of analysis of mortality for the period 1976 to 1988 inclusive, obtained by the subject-years method, with Quebec mortality for reference. In many respects the standardised mortality ratios (SMRs) 20 years or more after first employment were similar to those for the period 1951-75--namely, all causes 1.07 (1951-75, 1.09); heart disease 1.02 (1.04); cerebrovascular disease 1.06 (1.07); external causes 1.17 (1.17). The SMR for lung cancer, however, rose from 1.25 to 1.39 and deaths from mesothelioma increased from eight (10 before review) to 25; deaths from respiratory tuberculosis fell from 57 to five. Among men whose exposure by age 55 was at least 300 million particles per cubic foot x years (mpcf.y), the SMR (all causes) was elevated in the two main mining regions, Asbestos and Thetford Mines, and for the small factory in Asbestos; so were the SMRs for lung cancer, ischaemic heart disease, cerebrovascular disease, and respiratory disease other than pneumoconiosis. Except for lung cancer, however, there was little convincing evidence of gradients over four classes of exposure, divided at 30, 100, and 300 mpcf.y. Over seven narrower categories of exposure up to 300 mpcf.y the SMR for lung cancer fluctuated around 1.27 with no indication of trend, but increased steeply above that level. Mortality form pneumoconiosis was strongly related to exposure, and the trend for mesothelioma was not dissimilar. Mortality generally was related systematically to cigarette smoking habit, recorded in life from 99% of survivors into 1976; smokers of 20 or more cigarettes a day had the highest SMRs not only for lung cancer but also for all causes, cancer of the stomach, pancreas, and larynx, and ischaemic heart disease. For lung cancer SMRs increased fivefold with smoking, but the increase with dust exposure was comparatively slight for non-smokers, lower again for ex-smokers, and negligible for smokers of at least 20 cigarettes a day; thus the asbestos-smoking interaction was less than multiplicative. Of the 33 deaths from mesothelioma in the cohort to date, 28 were in miners and millers and five were in employees of a small asbestos products factory where commercial amphiboles had also been used. Preliminary analysis also suggest that the risk of mesothelioma was higher in the mines and mills at Thetford Mines than in those at Asbestos. More detailed studies of these differences and of exposure-response relations for lung cancer are under way.
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PMID:The 1891-1920 birth cohort of Quebec chrysotile miners and millers: mortality 1976-88. 828 Jun 38

The association between cooking fuels and the risk of respiratory disease in preschool children in Lucknow, India was studied. We interviewed mothers of 650 study children, randomly selected from among 28 urban poor neighborhoods. Children were eligible if they were less than five years of age, free of congenital heart disease, malignancy, and compromised immune status. Respiratory disease (defined as one or more of the following: runny nose, cough, sore throat, breathlessness, and noisy respiration) was assessed by observation. Exposures included the types of cooking fuels and duration of their use in the last week and other potential predictors of respiratory disease. Odds ratios (ORs) for disease were adjusted for covariables using multiple logistic regression. The point prevalence of respiratory disease was 14.5%. Cooking fuels used were wood (56.0%), kerosene (24.2%), coal (19.2%), gas (15.4%), and dung cakes (8.6%). Use of dung cakes, a sun-dried mixture of cow or buffalo dung and straw, as cooking fuel was associated with respiratory disease (adjusted OR = 2.69, 95% confidence interval [CI] = 1.37-5.31, P = 0.004), as was overcrowding in the bedroom (adjusted OR = 1.25 for each additional person, 95% CI = 1.11-1.41, P = 0.001). Age, weight, gender, family income, and household structure were not associated with disease. Use of dung cakes as cooking fuel and overcrowding in the bedroom increased the risk of respiratory disease. Interventions to modify oven design or install chimneys and, where feasible, to reduce the number of people sleeping together should be considered.
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PMID:Effect of cooking fuels on respiratory diseases in preschool children in Lucknow, India. 870 22


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