Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Contrary to certain industrial countries which secure an impressive decrease in coronary heart mortality, Poland has had, especially in the last decade, the significant increase of morbidity and mortality caused by cardiovascular diseases. Although this phenomenon concerns mainly the middle-age mean groups, special care for the whole population should be undertaken. The successful way to decrease the death rate and morbidity attributed to coronary heart disease (CHD) are the long-term prevention programs as for example Multiple Risk Factor Intervention Trial, Belgian Heart Disease Prevention Project, Lipid Research Clinics Coronary Primary Prevention Trial and others. Because there is some evidence that certain risk factors occur also among children, it seems that the effectiveness and efficacy of such prevention programs may be increased when started in the young population.
 ...
PMID:Cardiovascular diseases risk factors in male population from mining vocational schools of the Lublin Coal Basin. 136 98

From 1958 to March 1987 we corrected 704 patients with pectus excavatum. The condition occurred more frequently in boys (544 patients) than girls (160 patients). In the majority of patients (86%), the defect was evident at birth or within the first year of life. Musculoskeletal abnormalities were identified in 133 patients (scoliosis, 107; kyphosis, 4; myopathy, 3; Poland's syndrome, 3; Marfan's syndrome, 2; Pierre Robin syndrome, 2; prune belly syndrome, 2; neurofibromatosis, 3; cerebral palsy, 4; tuberous sclerosis, 1; and congenital diaphragmatic hernia, 2). Sixteen patients had associated congenital heart disease. A family history of chest wall deformity was present in 37% of the cases and a history of scoliosis in 11%. Surgical correction was performed using a uniform technique for bilateral subperichondrial resection of the deformed costal cartilages and sternal osteotomy resecting a wedge of the anterior cortex and fracturing the posterior cortex. Anterior displacement was maintained with silk sutures closing the osteotomy defect. In 28 early cases, the sternum was secured by intramedullary fixation with a Steinman pin. All repairs were completed with a low complication rate (4.4%; pneumothorax, 11; wound infection, 5; wound hematoma, 3; wound dehiscence, 5; pneumonia, 3; seroma, 1; hemoptysis, 1; hemopericardium, 1). Six complications were associated with Steinman pin fixation (hemoptysis, seroma, hemopericardium, pneumothorax, 3). Major recurrence occurred in 17 patients (2.7%) and led to revision in 12. Satisfactory long-term results were achieved in the remaining 687 patients, with follow-up ranging from 2 weeks to 27 years. Mean follow-up was 4.3 years.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Surgical repair of pectus excavatum. 320 60

Sex differences in mortality vary widely among the developed countries. Male overmortality is highest in Finland and the USSR, followed closely by France, Poland, the USA and Canada. The differential is lowest in Japan, Ireland and in south-eastern Europe. The sex mortality ratio is highest at ages 15-24 years with a second peak generally occurring around age 60. The excess mortality of males at the younger ages is due largely to motor vehicle accidents while higher death rates from heart disease and lung cancer in particular account for a substantial proportion of male excess mortality during the later years of working life. During the course of the 20th century, the impact of sex differences in mortality from the infectious and parasitic diseases has declined, as has the contribution from maternal mortality. Males have also benefited from a decline in industrial accidents but this has been more than countered by rising death rates from heart diseases, lung cancer and motor vehicle accidents.
 ...
PMID:Using national mortality data to study the changing sex differential in mortality. 651 86

The Belgian Heart Disease Prevention Project is a controlled multifactorial preventive trial. It is basal on the well-documented epidemiologic notion of major coronary risk-factors: hypercholesterolemia, hypertension, smoking and obesity. This Project has been executed in industries, in males aged 40-59 yrs at the base-line screening. It is part of the WHO European Collaborative Trial including the United-Kingdom, Italy, Poland and Spain. This trial should verify a double work-hypothesis: 1 degree it is possible to modify significantly the coronary risk profile in middle-aged males through a comprehensive intervention program, 2 degrees this modification should, in turn, significantly reduce total mortality as compared to a control group. The authors discuss the pros and cons of a preventive trial in industry and review the numerous problems raised by the difficulties in modifying well-established life-styles as well as those related to the follow-up morbidity and mortality. Final screening took place in 1979-80 and results regarding incidence should be available by 1981.
 ...
PMID:[The Belgian Heart Disease Prevention Project (author's transl)]. 730 12

Samuel Rosen originator of the surgical procedure so called mobilization, was second only to Juliusz Lempert as one of the great modern discoverers of new surgical techniques in the treatment of otosclerosis. This was the result of a chance discovery during routine stapes mobility test of the ossiculat chain before fenestration. Rosen having had excellent scientific training and knowledge was well prepared to interpret accidental stapes mobility and so design a new surgical technique. This operation enabled thousands of patients with otosclerosis to regain their hearing. However, he did not receive widespread acclaim in his own country. He received many invitations from abroad, travelled to several countries around the world where he taught stapes mobility testing and demonstrated his surgical procedure. In 1957 he also visited Poland, where he was born. He did not however limit himself to microsurgery of the ear. He created a group of international scientists who on the basis of investigations carried out by some of them, in the quiet noiseless African bush demonstrated that not only hearing is protected and the ageing process of this sensory organ delayed but also the development of arteriosclerosis is slowed down that which is the root cause of more and more cases of heart disease which among other factors can be attributed to the noisy stress ridden world we live in. After much success and fame which he achieved throughout the world, the American Medical Association awarded Sam Rosen a gold medal in 1967. But this too was not widely accepted by all his colleagues in his own country. He died in 1981 in China.
 ...
PMID:[Samuel Rosen (1897-1981): the originator of stapes mobilization]. 1076 30

Over the next 10 years, heart failure is likely to become a medical and sociological problem as a result of improved treatment of ischaemic heart disease and hypertension. At present, in Poland, there are only 50% of the cardiological or cardiac surgery procedures (coronarography, PTCA, CABG, surgery of congenital or acquired heart disease) performed compared to Western Europe. After being registered on the waiting list, it can take anything between 3 and 12 months before the procedure is done. Patients with heart failure have diagnostic tests such as ECG, chest X-ray, and biochemical evaluation performed regardless of the level of care. When echocardiography, exercise testing or Holter monitoring is required, it is done at specialist or reference specialist facilities with a waiting time of approximately 1-3 months. Pharmaceutical treatment of CHF is also inadequate. ACE inhibitors are prescribed in approximately 68% of patients. The average prescribed dosage is far from that recommended in guidelines. Only 18-29% of patients with HF are on beta blockers. The improvement of cardiological care standards depends mainly on the financial resources of State Health System Agencies.
 ...
PMID:Management of heart failure patients in Poland. 1195 52

In recent years a number of studies concerning ischaemic heart disease prevention have been published. Evidence from clinical and epidemiological research has led to the formation of new guidelines, especially in the field of secondary prevention. Polish Cardiac Society also published recommendations on prevention of ischaemic heart disease. Relatively little is known about how well physicians in Poland follow the guidelines. No comprehensive studies concerning risk factories management after myocardial infarction or myocardial revascularization has been conducted in Poland. Patients with established coronary heart disease were deemed to be the top priority for prevention. However, little is known about quality of medical care in this high risk population. Therefore the Cracovian Program for Secondary Prevention of Ischaemic Heart Disease was planned. The aims of the Cracovian Program are: to monitor quality of clinical care (both in clinical and general practice) in the field of secondary prevention of ischaemic heart disease, and to assess factors influencing quality of medical care. The secondary aim of the survey is to improve integration of secondary prevention into clinical practice through meetings with physicians from Cracow cardiology departments and general practitioners, as well as to improve patient compliance and motivating them to change their lifestyle. In the first stage, which was carried out in 1997-98, an evaluation was conducted to access the realization of recommendations concerning secondary prevention. An assessment of integration of ischaemic heart disease prevention into clinical practice can now be performed. The genesis, aims and methods of the Cracovian Program for Secondary Prevention of Ischaemic Heart Disease are discussed in this paper. The quality of hospital, as well as postdischarge care in the field of secondary prevention is described in the next two publications.
 ...
PMID:[Krakow Program for Secondary Prevention of Ischaemic Heart Disease. Part I. Genesis and objectives]. 1198 34

Ischaemic Heart Disease (IHD) is still an essential health problem in many countries. In Poland it is one of the leading causes of cardiac deaths, while in western countries and in the USA mortality rate due to heart diseases decreases. The prevention of coronary vessels diseases is a long and a hard process. There is a need to start an early prophylactic action. The programs of primary and secondary prevention should be directed to as many people as possible. In individual strategy any action should be based on the assessment of the degree of complete risk with regard to every single person. Directives and standards elaborated by the Committee of Prophylaxis are helpful. In this research the group of 105 health service female workers were prepared to carry out further preventive searches towards the IHD danger. The following factors were taken into account: the level of total cholesterol (LDL, HDL and triglycerides level), hypertension, cigarette smoking, overweight and obesity, diabetes. The factors mentioned above defined as global risk elements were examined among three age groups: 35-39 years, 40-45 years, 46-50 years. Coronary hazard was established in accordance with the Card of Prophylaxis IHD of Polish Cardiological Society. The main purpose of this research was to identify the IHD risk factors as well as to evaluate its danger among women.
 ...
PMID:[Occurrence of risk factors for ischemic heart disease among women--health service workers]. 1452 77

As evidenced by clinical trials, sterols and stanols may reduce LDL-cholesterol more potently than the restriction in the dietary intake of saturated fatty acids and cholesterol. So far, in Poland no clinical trials on the preventive applications of plant sterol margarines were conducted. Therefore, the objective of our study was to confirm their utility in primary prevention of cardiovascular disorders in young, healthy men who habitually consume butter. The present study was conducted on 42 healthy men (24.5 +/- 6 yr)--priests students living throughout the study in a boarding house and 4 weeks consumed during the study the same amounts (portions) of all diet elements, and the only difference were the two compared fats used in the study. 31 men consumed daily 15 g of extra butter (30 g/d), and 31 men consumed twice daily 15 g of margarine (30 g/d) with the addition of plant sterol esters amounting to 8 g/100 g of the product. Total cholesterol reduction by 7% (p < 0.001), and above all the LDL reduction by as much as over 11% (p < 0.001) confirm the beneficial effect of sterols on lipid parameters. The first time we observed reduction of oxidized LDL (oxy-LDL) by as much as 21% (p < 0.001) after consumption of margarine with plant sterol. This results suggest that sterols have pleiotropic effects, similar to statins. Our proposal of this results is that sterol have anti-inflammatory effect, probability by reduction of oxysterols from food. Of note is the fact that dietary sterol intake did not cause any changes in the HDL fraction level. Also the observed reduction in the atherogenic index (LDL-C/HDL-C) by over 11% (p < 0.001). On the other hand, the disadvantageous effect of butter-containing diet on blood serum lipids, with a trend towards their increase, was confirmed in the present study. The results obtained indicate a potent hypolipaemic activity of dietary sterol intake in normocholesterolemics young men, and probably that is the one of the important methods of prevention heart disease.
 ...
PMID:[The impact of plant-sterol supplemented diet on the LDL and oxidized-LDL levels in young men]. 1456 91

The Cracovian Program for Secondary Prevention of Ischaemic Heart Disease carried out in cooperation with the Cracow Branch of Polish Cardiac Society is the first and so far the only attempt in Poland to extensively assess the quality of care in terms of secondary prevention of ischaemic heart disease, at the same time trying to influence both the physicians and patients. The results of the 1st stage of the Cracovian Program conducted in 1997-98 indicate that the recommendations for secondary prevention of ischaemic heart disease are not implemented to a satisfactory degree during hospitalization in cardiology departments of university and general hospitals in Cracow, as well as in the post-discharge period. Because of this, measures were undertaken to improve the quality of secondary prevention. Current recommendations for secondary prevention of ischaemic heart disease were presented and discussed during trainings for physicians from the participating centres and primary care physicians. At the same time the results of the 1st stage of the Cracovian Program were presented and the discrepancies between recommendations and everyday practice were identified. Two types of leaflets concerning secondary prevention were also given to patients discharged from the participating departments. In the 2nd stage of the Cracovian Program for Secondary Prevention of Ischaemic Heart Disease carried out in 1999-2000, the implementation of recommendations on secondary prevention was reassessed. The analysis of data obtained in the 2nd stage shows to what extent progress in research dealing with patients with ischaemic heart disease is reflected in everyday practice. It also allows for the evaluation of the impact of the above described intervention on the frequency of achieving the goals defined in the guidelines of cardiac societies. In this paper the genesis, outline and objectives of the project are discussed as well as the methods of intervention applied. The implementation of secondary prevention guidelines both during hospitalization and after discharge will be discussed in separate publications.
 ...
PMID:[Cracovian program for secondary prevention of ischemic heart disease. Methods of intervention]. 1457 12


1 2 3 Next >>