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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was designed to assess HDL levels in children of young men with IHD, compared with children of asymptomatic men. Like their fathers, sons of patients with heart disease, had significantly lower HDL cholesterols than controls. This difference was independent of fasting triglycerides, obesity, diet or physical activity, and was the only "coronary risk factor" in this young age group.
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PMID:High density lipoprotein levels in children of young men with ischaemic heart disease. 22 9

The development of a device is reported called the Large-scale integrated Motor Activity Monitor to examine physical activity during individuals' normal daily lives. The unit which is slightly larger than a wrist watch records body movement when worn at various body locations. Two population studies were conducted to evaluate the units. Experiment 1 examined 20 male graduate students for a two-day period. The data indicated that the units were sensitive to individual differences in physical activity and did not interfere with normal activities. Experiment 2 compared 10 Physical Education majors with 10 non-Physical Education majors by having individuals log activities and record movement counts for a two-day period. The movement data revealed that the monitors significantly discriminated between the two populations. The energy expenditure derived from the specific loggings was highly related (r = +.69) to the trunk movements, indicating that the movement counts are an accurate estimate of physical activity. The high relationship to energy analysis, the sensitivity of the units and the ease of implementation indicate that the units may be useful in relating normal activity to acute heart disease and to risk factors such as obesity and lipoproteins.
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PMID:An objective measure of physical activity for epidemiologic research. 42 55

1496 women age 55 to 74 were studied in an effort to determine heart disease risk factor differences attributed to postmenopausal estrogen (PME) use. 39% of the females reported using estrogen at the time of the study, with peak hormone use in the 55 to 59 year age group. Analysis of the following possible confounding variables, social class, current cigarette smoking, family history of heart attack or diabetes and obesity found that only obesity was statistically significant ( P .001) and thus further analysis of PME use was adjusted for obesity. Results showed average cholesterol level was 9.4 to 20.4 mg/dL lower among PME users compared to nonusers. Although triglyceride level was higher in PME users at all ages it was only statistically significant for women aged 60-69 years. Mean systolic and diastolic blood pressures were 2 to 4 mm Hg lower in PME users and the average fasting plasma glucose level was significantly lower in young PME users only. Multivariate Hotellings T statistic was used to test for independence. While the study examined the net cumulative effect of PME use of putative heart disease, it did not examine specific estrogens, dosage or duration of use differences. The authors concluded that further studies are needed before final conclusions can be made regarding the use of PME as a risk factor reducer in heart disease.
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PMID:Heart disease risk factors and hormone use in postmenopausal women. 43 Aug 17

Forty-one patients with significant pulmonary emboli were reviewed. The presence of heart disease and obesity was found with relatively constant frequency throughout the groups presented. Postoperative infections (wounds or abscess) were frequently associated with fatal or significant pulmonary embolism, particularly after abdominal and pelvic operations. The infection rate (65 per cent) in patients in whom significant pulmonary embolism developed after abdominal and pelvic operations is particularly striking when compared to the overall infection rate of 7 per cent for major operations in our hospital. Recent studies of prophylactic minidose heparinization reveal an increased number of complications due to the heparin [24], and thus the proper selection of cases for prophylactic minidose heparin is mandatory. The data suggest that patients at high risk for the development of postoperative complications of infection are also at high risk for the development of significant pulmonary emboli and should be considered candidates for prophylactic minidose heparinization.
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PMID:Effects of concurrent sepsis with clinically significant pulmonary embolic disease. 43 30

A comparison of health status between 779 Seventh-day Adventists, who have a strong commitment to heal-related life styles, and two other groups of people--8363 persons referred by general practitioners and 9825 volunteers--was made. The Seventh-day Adventists showed less impairment of systolic and diastolic blood pressures, of plasma cholesterol and plasma urate concentrations, and of lung ventilatory capacity; and less obesity at most specific ages. With increasing age, the level of breathlessness, reported heart disease, hypertension, and hypertensive and diuretic therapy in this sample approached that of the comparative groups, possibly because of natural attrition of high-risk persons in the latter. Depression, sleeplessness, use of sedatives and tranquillizers were lower in the Seventh-day Adventists; although, once again, a drawing together of the three groups in older age categories was evident. It is concluded that the life style of Seventh-day Adventists is conducive to lessened morbidity, delayed mortality, and decreased call on health services in comparison with the general population.
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PMID:Health status of Seventh-Day Adventists. 47 Jun 66

A newborn boy presented with an acrocephaly characterized by a coronal craniosynostoses, open sagittal sutures and abnormally high and straight forehead. He was the only child of young, unrelated, healthy parents; there was no familial history of dysmorphy. Facial asymmetry was important and associated with posterior cleft palate, syndactylia of the tips and polydactylia of feet, due to a splitting of the first metatarsus. The child also had a congenital heart disease, like in half of the 15 published cases. In older children, mental retardation is usually observed, often associated with obesity and hypogonadism. Polydactylia permitted to exclude Apert's acrocephalosyndactylia in which there is a normal number of finger arms and which seems to be a dominant mutation, while the transmission of Carpenter's syndrome appears autosomal recessive, thus requiring restrictive genetic counselling.
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PMID:[Carpenter's syndrome]. 60 89

Exercise testing has a definite role in pediatrics today. Different methods are presented, and the value of maximal exercise with determination of oxygen uptake and blood lactate is stressed. In children with heart disease, exercise testing with precordial electrocardiogram can be of both diagnostic and prognostic value. The cardiovascular function at different intensities of exercise is evaluated, serious dysrhythmias may be revealed, hypertension judged and the effect of drug therapy can be checked by exercise testing. It is an important way in assessing the child's functional capacity after heart surgery in the decision whether she or he should take part in physical education and sports activities and in the choice of profession. It is also of great psychological value to the parents and the patient himself. In children with other chronic diseases, e.g., diabetes, obesity, asthma, neurocirculatory dysfunctions--physical training together with exercise testing is of importance for therapy and rehabilitation.
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PMID:Exercise testing in children. 72 65

The relationship between obesity and 18 different disease conditions was examined in a cross-sectional study of 73,000 weight-conscious women (TOPS Club members). The women reported an average of 1.6 disease conditions each (based on their responses on a questionnaire). Age-specific rates of occurrence for the age group 30-49 years were calculated for each disease condition. The conditions that were found to be significantly (P smaller than 0.001) correlated with obesity were diabetes, high blood pressure, gallbladder disease, gout, thyroid disease, heart disease, arthritis, and jaundice. When the crude relative risks of obesity for each disease condition were calculated, diabetes was found to be the highest (4.5), high blood pressure was second (3.3), and gallbladder disease was third (2.7).
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PMID:Relationship of ovesity and disease in 73,532 weight-conscious women. 80 96

In a 22-year followup of 3686 San Francisco longshoremen, a cohort analysis assessed job activity and six personal characteristics in relation to 395 fatal heart attacks. Four cohorts aged 35-44, 45-54, 55-64, and 65-74 in 1951 were studied annually for job shifts affecting energy output and for sudden or delayed death from heart attack by age 75. All subjects underwent multiphasic screening for heavy cigarette smoking, higher blood pressure, history of prior heart disease, obesity, abnormal glucose metabolism, and higher blood cholesterol. The first three of these characteristics added risk of fatal heart attack. The amount of risk varied in the four cohorts. Higher energy output on the job reduced risk of fatal heart attack, especially sudden death, in the two younger cohorts, where less active workers were at threefold increased risk. Lack of this effect in the two older cohorts could imply real differences in their work habits, such as being less energetic in heavy jobs or more energetic in light jobs than the younger cohorts. Or, before the study began, early deaths may have winnowed susceptibles from the two older cohorts. Combined low-energy output, heavy smoking, and higher blood pressure increased risk by as much as 20-fold. By elimination of these adverse influences, this population might have had an 88% reduction in its rate of fatal heart attack during the 22 years.
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PMID:Work-energy level, personal characteristics, and fatal heart attack: a birth-cohort effect. 84 74

The authors analysed clinically 108 patients (61 males and 47 females), aged below 50 years treated at the department of neurology, because of acute cerebral ischaemia. Attention is called to risk factors such as arterial hypertension, heart disease, atherosclerosis, obesity and diabetes which may be the cause of earlier development of ischaemic changes in the central nervous system. In the analysed group in 18 cases cerebral thrombosis, in 23 cases embolism, in 31 cerebral circulatory failure were diagnosed. In 36 cases the cause could not have been established.
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PMID:[Acute cerebral ischemic disease in patients under the age of 50]. 88 1


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