Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the clinical features, surface ECG findings, associated with congenital heart disease (CHD), and status at follow-up in 103 children who underwent intracardiac electrophysiologic evaluation of supraventricular tachycardia (SVT). Age at catheterization ranged from 2 days to 17 years (mean 4.2 years). Diagnosis of the mechanism was based upon standard electrophysiologic techniques. Of the 103 patients, 37 had reentry without a bypass tract (10 sinoatrial node, two atrial muscle, and 25 atrioventricular node); 51 had reentry with a bypass tract (28 manifest Wolff-Parkinson-White [WPW], 18 unidirectional retrograde accessory pathway [URAP], an five Lown-Ganong-Levine); and 15 had an ectopic focus (11 atrial, four junctional). Distinguishing features among the common types are depicted in Table III. We conclude that in children the various mechanisms of SVT (1) are likely to be found in different clinical situations, (2) have a different potential for surgical cure, and (3) have a different prognosis for long-term treatment. Since curative surgery was theoretically possible in 57% of our patients (WPW, concealed WPW, atrial, and junctional ectopic), we recommend electrophysiologic study in any patient who has had frequent recurrences of SVT for longer than 1 year and who requires drugs in addition to digoxin for treatment.
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PMID:Electrophysiologic studies of supraventricular tachycardia in children. I. Clinical-electrophysiologic correlations. 725 98

Documentation of arrhythmia in symptomatic patients with preexcitation syndromes may be difficult despite extended ambulatory monitoring (MON). We, therefore, examined 12 patients with Wolff-Parkinson-White (WPW) and ten with Lown-Ganong-Levine ECG anomalies to compare the yield of tachyarrhythmia on maximal treadmill testing (MTT) and on MON. Nineteen patients were free of associated heart disease. Average age for the group was 45 years (11 men and 11 women). Sustained atrial arrhythmias developed in four of 22 patients during MTT. All four were free of arrhythmia on subsequent MON. An additional four patients exhibited these arrhythmias on MON. We conclude that the use of both monitoring and exercise testing will enhance detection of arrhythmia in patients with symptomatic preexcitation.
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PMID:Exercise testing and ambulatory monitoring in patients with preexcitation syndrome. 744 86