Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During October and November 1977, eight newborns with critical congenital heart disease, six of these with left sided lesions, were admitted to a New Jersey newborn unit serving two predominantly rural counties with 9700 annual live births. The six left heart lesions (three cases of hypoplastic left heart, two of interrupted aortic arch, and one of aortic coarctation) represented 30% of all neonatal left sided lesions seen at the unit in the three year period 1976-8. The scan statistic for temporal clustering was significant (p less than 0.05). A case-control study was performed in which an average of four controls were matched to each case. A questionnaire was administered to the mothers of cases and controls concerning occupation, periconceptional and prenatal nutrition, radiation and chemical exposure, use of alcohol and tobacco, medications, immunisations, infections, and other exposures. No statistically significant differences between cases and controls were found on any of these items. Although no aetiology for this cluster of congenital heart anomalies could be found, it is of interest that three temporal clusters of fetuses or newborns with chromosomal trisomies have been reported in the medical literature whose conceptions were roughly contemporaneous with those of the infants in our series. These occurred in Rhode Island/Massachusetts, Maryland, and New York City. A speculative possibility is that these four point epidemics represented exposure to a common teratogenic agent, perhaps influenza B, in the winter of 1976/77 in the northeastern United States.
 ...
PMID:Investigation of a temporal cluster of left sided congenital heart disease. 651 89

A report on 5 men aged from 53 to 75 years whose clinical symptoms were characterized by a major attack. There was a striking temporal relationship between the onset of this and an influenza infection which, in these 5 patients with chronic heart diseases led to a severe, and in the youngest patient, even to a fatal course. In an acute heart attack it seems rational to take into consideration an acute influenza virus infection as a precipitating factor in existing chronic heart disease and to institute virological studies.
 ...
PMID:[Influenza A virus infection, a precipitating factor for the major heart attack (author's transl)]. 678 Aug 22

This study examines a large number of demographic, hospital, patient volume, and medical factors that may influence in-hospital mortality due to trauma. The authors use data from the 1977 and 1978 National Hospital Discharge Survey to assemble a case-control data set of severe injuries (n = 336). Cases are defined as "deaths from trauma," and control subjects are "injured survivors." Control subjects are frequency-matched to cases on the basis of overall severity, site of the most severe anatomic injury, and age. The analysis estimates the relative risk of mortality associated with different levels of the risk factors by the odds ratio. The unadjusted results indicate a significant impact of the following variables: sex (with males at higher risk), average severity of hospital case mix, number of severe trauma patients treated at a hospital (with high-volume hospitals at increased risk), ischemic heart disease and other forms of heart disease, malignant neoplasms, influenza and pneumonia, and emergency tracheotomy or tracheostomy. After adjustment using multiple logistic regression, the single significant risk factor is the presence of ischemic heart disease and other forms of heart disease. The implication of this finding is that hospitals exhibit little difference in mortality from severe trauma after adjustment for patient mix characteristics. Possible explanations for this result are tendered.
 ...
PMID:Mortality from traumatic injuries. A case-control study using data from the National Hospital Discharge Survey. 688 26

The combined cause-of-death category pneumonia and influenza (P&I) (International Classification of Diseases, Ninth Revision, codes 480-487) ranks as the sixth leading cause of death in the United States following heart disease, cancer, stroke, unintentional injuries, and chronic obstructive pulmonary disease. Changes in the epidemiology of Streptococcus pneumoniae and other recognized respiratory pathogens, the increasing occurrence of drug-resistant microorganisms, and the detection of new respiratory pathogens have heightened awareness of the public health importance of severe respiratory infections. To characterize the epidemiology of P&I deaths in the United States, CDC further analyzed underlying and multiple cause-of-death mortality files for 1979-1994. This report summarizes the results of this analysis.
 ...
PMID:Pneumonia and influenza death rates--United States, 1979-1994. 760 29

Viral respiratory infections are uncommon causes of pulmonary infiltrates in immunocompetent patients who undergo cardiothoracic surgery. In winter months, however, influenza can be acquired in the community preoperatively or in the hospital setting. The recognition of influenza cases is essential to prevent nosocomial transmission. Respiratory syncytial virus is also an important pulmonary pathogen in pediatric patients who undergo cardiothoracic surgery and may produce serious disease in children with underlying pulmonary or congenital heart disease. Viral infections of the respiratory tract are important causes of morbidity and mortality in heart and lung transplant recipients, especially cytomegalovirus (CMV). Other herpes viruses such as varicella zoster virus and herpes simplex virus may also occasionally involve the lung. Epstein-Barr virus has been incriminated in the pathogenesis of post-transplant lymphoproliferative disease, an uncommon but severe complication of transplantation. Except for Epstein-Barr virus, effective therapy exists for CMV and the other herpes viruses. Prophylaxis with ganciclovir is effective in preventing serious CMV infections in seropositive heart transplant recipients. However, better strategies are needed to prevent primary CMV infection in these patients.
 ...
PMID:Viral pulmonary infections in thoracic and cardiovascular surgery. 761 60

Recent additions to the immunization schedule include acellular pertussis vaccine, and hepatitis B vaccine for all infants and selected adolescents. The third dose of OPV is recommended at 6 months of age and the first dose of MMR vaccine at 12 to 15 months. A new vaccine against Haemophilus influenzae type b has been licensed. Children aged 6 months and older with asthma, diabetes, or heart disease should receive influenza vaccine. Children aged 2 years and older with asplenia, immunosuppression, and nephrotic syndrome may be candidates for pneumococcal immunization.
 ...
PMID:Childhood immunization guidelines: current and future. 785 58

Influenza is a major cause of debilitating illness and premature death in the United States, particularly among persons aged > or = 65 years and those with chronic conditions such as lung or heart disease, diabetes, and cancer. Medicare reimbursement for excess hospitalizations during influenza epidemics ranges from $750 million to $1 billion (1). In May 1993, influenza vaccination became a covered Medicare benefit after its potential cost-effectiveness was established by the Medicare Influenza Vaccine Demonstration (2). During the fall of 1993, the Health Care Financing Administration (HCFA) initiated an information campaign to promote use of the influenza vaccination benefit, implemented simplified billing procedures, and improved electronic billing capabilities. However, reports during the 1993-94 influenza season suggested problems experienced by state and local health departments in implementing the new benefit. To characterize public influenza vaccination programs and problems with implementing this benefit, in the spring of 1994, CDC collected information from all 63 state and local health departments receiving federal immunization grants. This report summarizes the reports from these programs.
 ...
PMID:Implementation of the Medicare influenza vaccination benefit--United States, 1993. 793 12

Pneumonia and influenza (P&I) are the sixth leading cause of death in the United States, and persons aged > or = 65 years and persons with chronic conditions (e.g., lung or heart disease, diabetes, or cancer) are at greatest risk for P&I. During major epidemics, hospitalization rates for persons at highest risk may increase twofold to fivefold. However, only 30% of persons aged > or = 65 years responding to CDC's National Health Interview Survey for 1989 reported having received the influenza vaccine during the previous year. In 1988, the Health Care Financing Administration (HCFA) and CDC began a congressionally mandated 4-year demonstration project to evaluate the cost-effectiveness to Medicare of providing influenza vaccine to Medicare beneficiaries. This report presents final results of the Medicare Influenza Vaccine Demonstration conducted during 1988-1992.
 ...
PMID:Final results: Medicare influenza vaccine demonstration--selected states, 1988-1992. 833 91

Based on data from the Dutch Central Bureau of Statistics, the impact of influenza on mortality in The Netherlands was estimated for a 22.5-year period (1967-1989) in four age groups and three entities of disease, using Poisson regression techniques. Our analysis suggests that, on average, more than 2000 people died from influenza in The Netherlands each year, but in only a fraction of these deaths was influenza recognized as the cause of death. For each case of death registered as caused by influenza (registered influenza mortality), 2.6 additional cases of death registered as due to causes other than influenza, nevertheless, were influenza-related (non-registered influenza mortality). Therefore, the overall impact of influenza on mortality is estimated to be greater than registered influenza mortality by a factor of 3.6. Those under 60 years of age accounted for 5% of all non-registered influenza deaths, whereas people aged 60-69, 70-79 years and > 80 years accounted for 12%, 29% and 54% of such deaths, respectively. When extrapolating the figures for the Dutch population of 1989, we could attribute, on average per season-year, 82 deaths per 100,000 people > 60 years, 143 in people > 70 years, and 280 in people > 80 years. Of all non-registered influenza cases of death, 47% were estimated to occur in people with heart disease as a primarily reported cause of death, 23% in those with lung disease, and 30% in those with other diseases. This study stresses the serious effects of influenza, mainly in the elderly (95% of non-registered influenza mortality).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Impact of influenza on mortality in relation to age and underlying disease, 1967-1989. 850 93

Records of 133 AIDS patients treated at the Internal Medicine and Cardiology Service of the University Hospital in Brazzaville between January 1986 and December 1995 were analyzed. During the 10 years, 342 patients with AIDS were admitted, of whom 133 (38.9%) had recently developed cardiopathies. Patient ages ranged from 17 to 78 years (average, 35 years). 75 were male and 58 female. Clinical manifestations were often minor or even absent, but patient histories revealed functional symptoms. The patients were generally in an advanced stage of HIV infection. Clinical examination showed myocarditis to be the most frequent condition, with 81 cases (61%). Isolated liquid pericarditis was observed in 47 cases, including 15 with blockage. 25 patients showed mitral insufficiency, 16 tricuspid insufficiency, 2 aortic insufficiency due to infectious endocarditis, and 2 myocardial infarct. In 17 cases the onset was abrupt, with influenza-like symptoms. Standard cardiac radiography demonstrated cardiomegaly in all cases. Only 23 of the 133 electrocardiograms were considered normal. The other 110 showed various anomalies, of which the most frequent and significant was diffuse and concordant inversion of the T waves. Cardiac ultrasound in the 90 patients examined allowed diagnosis of 58 cases of myocarditis, 27 of liquid pericarditis not associated with myocarditis, and 5 of infectious endocarditis. 20 deaths were observed. The condition was stabilized in 85%. The fatality rate for AIDS-related cardiopathy is relatively low, on the order of 15-20%. Early diagnosis allows initiation of treatment, which often reduces patient discomfort.
 ...
PMID:[The heart and AIDS]. 902 16


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>