Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The global population reached two billion people in 1927 and six billion in 1999. If the medium variant projection of the United Nations were to materialize, the Earth's population would reach nine billion in 2054. However, such a brave new world will be inhabited by a brave old humankind; in 2050, 16.4% of the world population and 27.6% of the European population are projected to be 65 years and above, and in 14 countries, including nine European ones, more than 10% of the total population will be 80 years or older. The United Nations also project a world-wide decline in the number of children and in total fertility, and by 2050, there will be more elderly than children in several parts of the world, particularly in Europe. It seems likely that many of our classical institutions, for instance healthcare -- unless reformed -- will cater increasingly for the needs of a population structure that no longer exists. The World Health Organization projects that by the year 2020, global health trends will be dominated by the ageing of the world population, the HIV/AIDS epidemic, tobacco-related mortality and declining child mortality. Furthermore, the leading causes of disease burden will be heart disease, depression and traffic accidents. How can we meet the giant challenges of the 21st century? In the view of the author, the most rational remedy must be a quantum leap in research in general and in medical research in particular.
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PMID:The demographic revolution and our common future. 1131 79

HIV-positive cases among women are rising at such a rapid rate that by the year 2000, AIDS will be the second greatest killer of women between the ages of 18 and 44, surpassing heart disease and accidents. Womens' needs, however, are being largely ignored in the fight against this disease. Recently, AZT, a drug that was shown to help counter the HIV virus in men, has been shown to cut the risk of perinatal HIV infection by two-thirds in a trial on pregnant women. Some women, however, do not trust the study's findings because they worry that AZT may turn out to be the thalidomide of the 1990s. Until AIDS symptoms were defined as including uniquely female complications, women were left out of access to publicly-funded medical care and government disability benefits. Additionally, health care providers are not doing enough to help newly diagnosed women deal with the problems of domestic violence, abuse, and intimidation. Karen Rothenberg, of the University of Maryland School of Law, states that HIV-positive women are more apt to fear loss of their social structures, such as marriage, partnership or family, than economic complications, such as loss of employment or health insurance.
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PMID:Women seek greater influence in research, prevention policies. 1136 35

The Defense Department has written into its budget a proposal to discharge all HIV-positive members of the armed services. The House Committee on National Security has approved the fiscal 1996 defense budget with the ban included. Rep. Robert K. Dornan, R- Calif., contends that having HIV-positive service members in the military compromises the nation's readiness because, under Defense Department policy, they cannot be stationed abroad. However, only one-fifth of all service members on limited assignment have HIV, the others have diseases such as heart disease, cancer, and diabetes. This shows the military's readiness to discriminate against HIV-positive individuals, according to William J. Freeman of the National Association of People with AIDS. Currently all recruits are tested for HIV; if they test positive, they are denied entry to the armed services. All service members are tested annually for HIV antibodies. In anticipation of cutbacks in military-related AIDS research due to the Republican control of Congress, the military has begun to eliminate most of the AIDS research it conducts.
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PMID:HIV ban in military. 1136 30

According to a survey conducted by the National Leadership Coalition on AIDS, full-time workers in the private sector are more concerned about AIDS than other diseases. Half of the respondents said they were concerned about AIDS, 32 percent said cancer, and 7 percent said heart disease. The survey also found that 34 percent of working Americans know or have known someone with HIV or AIDS. Of the people surveyed, 78 percent believe people with HIV or AIDS should be treated like any other employee; 32 percent said people with HIV or AIDS should either be immediately fired or placed on disability leave.
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PMID:AIDS is biggest concern among workers, survey says. 1136 37

President Clinton recently signed the 1996 Department of Defense Authorization bill, a provision of which has been called the most regressive AIDS-related policy yet written. The provision, championed by Rep. Bob Dornan (R-CA) and Sen. Trent Lott (R-MS), requires that all HIV-positive persons in the military be immediately discharged. This is a significant departure from current policy that treats HIV-positive service personnel the same way as those with cancer, diabetes, or heart disease--if they can do the job, they can remain in the military. President Clinton is said to privately believe that the measure is unconstitutional since it singles out one class of disability for harsher treatment than others.
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PMID:Bill to dismiss HIV-positive military unfair, defies Constitution. 1136 45

Highly elevated triglyceride levels being reported in HIV-infected people are a concern because they can contribute to heart disease, stroke, and pancreatitis. The elevated levels may be the result of medication on the liver, dietary habits, or malabsorption of key nutrients. Preliminary studies have shown that dietary and vitamin supplements may help lower the levels to a more normal and safe range. Strategies to reduce triglyceride levels are described.
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PMID:High triglyceride levels: their danger and what can be done. 1136 11

AIDS is having a devastating impact on communities of color, leading the Centers for Disease Control and Prevention (CDC) to promote a new agenda to allocate Federal HIV prevention funds. The new agenda will compensate for the changing demographics in the epidemic. Two recent summits in Boston and Atlanta gave African Americans an opportunity to voice their opinions about the issue. There is a growing level of alarm that the community planning process has not been effective in addressing the needs within the African-American community, where AIDS now kills more people under the age of 45 than cancer, homicide, and heart disease. A national survey by the Kaiser Family Foundation found that African Americans are twice as concerned as the general US population about becoming infected with HIV. African Americans agree that the government should fund needle-exchange programs. Some activists are calling for a movement within the African American community that will mirror the tactics and effectiveness of programs developed by and for gay men.
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PMID:Communities of color seek reform in HIV funding. 1136 59

In an interview with Treatment Issues, Dr. Joseph Sonnabend indicates that use of protease inhibitors may contribute to the development of heart disease. Protease inhibitors appear to abnormally increase triglycerides and cholesterol levels, without a corresponding increase in HDL. The addition of androgenic and anabolic steroids in the HIV treatment mix adds to cardiovascular risk. Preventive measures for patients on steroids include monitoring hematocrit levels, and possibly testosterone levels, to make sure they are not too high. Standard preventive measures for heart disease, such as diet, exercise, and the use of certain drugs, are recommended, although an aggressive approach may be required. Drugs such as Lipitor and Zocor can be used to help reduce lipid abnormalities.
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PMID:Heart disease in people with HIV: an interview with Joseph Sonnabend, M.D. Interview by Dave Gilden. 1136 76

U.S. District Judge William Wayne Justice has ruled that the Texas prison system must remain under judicial supervision partially due to lingering doubts about the sufficiency of HIV treatment and the officials' responses to rapes by inmates. The judge noted that the system has improved greatly since 1972, when inmates sued because of poor medical care, but it remains below standards. The prison system's health care treatment was found to not reduce viral loads effectively. Medications were difficult to obtain because of lockdowns and long pharmacy lines. Other deficiencies were found in treating heart disease, diabetes, and psychological disorders.
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PMID:Judge raps Texas for HIV care, rape prevention in prisons. 1136 13

The changes and complications in metabolic status and lipodystrophy stemming from HIV treatment are examined. Research results from international conferences are discussed; topics include mechanisms of action and outcomes of recent treatments for lipodystrophy. These therapies cite the benefits of diet and exercise and the use of liposuction. Also examined are studies that investigated the effects of switching HIV protease drugs. Concluding comments address the possible connection between heart disease and lipodystrophy.
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PMID:Understanding and treating protease paunch. 1136 10


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