Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In situ saphenous vein bypass grafts were used to revascularize 109 lower extremities in 99 patients during 1984. Of those, 102 were single length grafts carried out in 53 males and 39 females with an average age of 69 and 75 years old, respectively. The expected associated risk factors were observed: smoking in 69 per cent, hypertension in 57 per cent, heart disease in 52 per cent and diabetes in 31 per cent of the patients. Grafts were performed for limb salvage in 71 patients, claudication in 30 and aneurysm in one. Single length grafts originated from the common (47), superficial (27), deep femoral (18) or popliteal (four) arteries or proximal Dacron (polyester) grafts (six); 93 per cent of the grafts were to an infrageniculate target site, while 44 per cent extended to an infrapopliteal artery and 7 per cent to the ankle. Operating time including completion angiography, which was done in every instance, was comparable to that with reversed vein grafts. The patency rate at one year was 96 per cent or 87 per cent when claudication or limb salvage was the indication for operation, and 92 per cent or 86 per cent when the distal anastomosis was to a popliteal or infrapopliteal artery. Limb salvage rates were 97 per cent at one month and 91 per cent at one year. All five amputations occurred in patients receiving infrapopliteal grafts for gangrene. The survival rate was 97 per cent at one month and 85 per cent at one year.
 ...
PMID:The transition to "in situ" vein bypass grafts. 372 22

Catheterization of the umbilical artery is a common procedure in neonatal intensive care units. The authors studied the records of 100 consecutive newborns who underwent this procedure to review the indications for and complications of umbilical artery catheterization and to discuss preventive measures and alternative techniques. Only polyvinylchloride barium-impregnated catheters were used (nos. 3.5 and 5.0 French). The commonest indications were respiratory distress syndrome, asphyxia and congenital heart disease. Of the 100 infants, 75 weighed less than 2500 g. Ampicillin and calcium were the commonest medications infused (70 and 65 babies respectively). There were three major complications, two of which were gangrene of the lower extremity. Amputation of the foot was necessary in one and amputation of the toes in the other. The third complication was the development of gluteal necrosis. In all three cases, catheter placement was low and the infusion was ampicillin. In two of the babies, calcium was also administered. Minor complications were seen in 32 cases, with vascular spasm in the lower limb being the most common. All catheter tips were cultured; there was bacterial colonization in 13%, Staphylococcus epidermidis being the commonest organism. Proven necrotizing enterocolitis was seen in eight infants and was suspected in eight others. Blanching is a serious sign and was seen in the three infants with major complications. The infusion should be stopped immediately. When necrotizing enterocolitis is suspected, the catheter should be removed.
 ...
PMID:Catheterization of the umbilical artery in neonates: surgical implications. 397 Dec 40

Arterial embolism of the upper extremity is not as rare and especially not as benign in all instances as was considered in the past. Postembolic ischemic changes or frank gangrene of fingers or hand may occur in a substantial percentage of patients. This paper will attempt to update the current concepts of this problem. The clinical data and the methods for evaluation of the degree of viability of the hand or forearm will be reviewed. Arteriography is recommended more liberally than in the past. Arterial embolectomy usually performed under local anesthesia is widely applicable in view of the simplicity, safety and effectiveness of the balloon catheter technique. The overall results based on a compilation from six reports indicate that complete circulatory restoration occurred in 55% and salvage without a return of wrist pulses in 24%. Gangrene occurred in 9.3% and mortality in 11.8%. In general, mortality following embolectomy is primarily related to the gravity of the cardiopathy and least to the surgical procedure.
 ...
PMID:Cardiogenic embolism of the upper extremity. 708 39

Many people need to go through a period of emotional adjustment before they can accept their diabetes. Much skill, patience and understanding is needed from the health professional to help them through this process. Many diabetic people go through a pattern of emotional reactions which are similar to grief reactions. These include shock and disbelief, denial, anger, depression and withdrawal when they realise the diabetes will not go away, and mourning for the loss of a life-style that was comfortable, familiar, secure. They also feel the loss of indulging in things they once found pleasurable, and the loss of independence. Finally comes the stage of acceptance. The person's fears of developing long-term complications-going blind, having heart disease, developing gangrene and so on-need to be addressed fairly early on. Education about avoiding complications is important but may not be effective until the person has worked through feelings of fear and grief. To the health professional it may seem astonishing that the patient does not comply with the treatment and accept the good advice that is given, but these reactions can often be understood in the light of the emotional adjustments that are taking place. Knowledge alone is not enough. Although health professionals need to give patients information and advice, they also need to help them express their feelings and provide emotional support during the adjustment process.
 ...
PMID:How I coped emotionally with diabetes in my family. 868 Jan 76

A pre-term baby with complex congenital heart disease was operated upon for construction of Blalock-Taussig (B-T) Shunt. Soon after surgery the upper limb became blanched and cold. Despite conservative measures to improve circulation, limb ischaemia progressively worsened and resulted in fore quarter gangrene.
 ...
PMID:Fore quarter gangrene: complication of Blalock-Taussig shunt. 910 32

This retrospective study analyses the clinical presentation, surgical management and early outcome of 174 patients (mean age +/- SEM: 73 +/- 15 yrs) admitted for critical limb ischaemia. 145 (84%) had tissue loss at admission: toe gangrene or ischaemic ulcer in 77, and gangrene extending beyond the forefoot in 68. 87 primary limb amputations and 107 revascularisations were performed at iliofemoral (n = 20), suprapopliteal (n = 22) or infrapopliteal level. The postoperative mortality rate was 14% in the "Amputation" group and 9% in the "Revascularisation" group but the difference was not statistically significant. Infective complications were comparable in both groups, although 5 of 14 deaths after amputation were directly related to infection and all deaths after revascularisation resulted from cardiovascular complications. The early limb salvage rate after revascularisation was 82%. 19 secondary limb amputations were performed for bypass failure. Patients in whom primary amputations were required were older (p < 0.03) and had significantly higher rates of heart disease and nonambulatory status (respectively, 24 vs 17%, p < 0.05; and 37 vs 13%, p < 0.001) than patients in whom revascularisation was performed. Ischaemic rest pain and tissue loss confined to digit gangrene or ischaemic ulcer occurred more frequently than extensive gangrene in the "Revascularisation" group (p < 0.0001), while extensive gangrene extending beyond the forefoot occurred more frequently than ischaemic rest pain and tissue loss in the "Amputation" group (p < 0.0001). Late presentation of patients and enhanced tissue loss are probably the reasons for the higher primary amputation rate in our patients compared to that observed elsewhere. In patients amenable to revascularisation (56%), arterial reconstruction for critical limb ischaemia improves the chances of limb salvage.
 ...
PMID:Surgical management of critical limb ischaemia in the French West Indies. 986 59

Congenital heart defects in low birth weight infants are typically managed with supportive therapy or palliative surgery, and definitive repair is delayed. However, the morbidity of such an approach has been shown to be high. Recent reports emphasize early surgical repair with good results in low birth weight and premature babies. However, there are no data on the outcomes in infants with very low birth weight (<1,500 g). Since 1990, the authors performed complete repair of congenital heart defects (other than isolated patent ductus arteriosus) in 20 infants weighing 1,500 g or less. Defects included aortic coarctation (n = 6), ventricular septal defect (n = 5), tetralogy of Fallot (n = 2), transposition of great arteries (n = 2), truncus arteriosus (n = 2), total anomalous pulmonary venous return (n = 1), double outlet right ventricle (n = 1), and pulmonary atresia with intact ventricular septum (n = 1). Preoperative morbidity was more common in patients who were referred late for corrective surgery. Modification of techniques of neonatal cardiopulmonary bypass were used. There were 2 early deaths (10%) caused by foot gangrene (n = 1), and pulmonary complications (n = 1). No patient had evidence of postbypass intracranial hemorrhage. At a median follow-up of 40 months, there was 1 late death, and 4 patients underwent a total of 5 surgical and catheter reinterventions. There was no evidence of neurological sequelae attributable to surgery. In most cases, delaying repair of congenital heart defects in low and very low birth weight infants does not confer any benefit and is associated with a higher incidence of preoperative morbidity. Complete repair of both simple and complex congenital heart lesions can be performed successfully in such patients with good early and medium-term results. Postoperative growth after repair approximates the normal growth curve for low birth weight infants without congenital heart disease. It is recommended that with few exceptions, such infants, especially when symptomatic, undergo early surgical correction rather than prolonged medical management or other forms of palliation.
 ...
PMID:Cardiac surgery in infants with very low birth weight. 1080 31

This brief report describes an unusual complication of femoral venous access placement. A 17-year-old male underwent cardiopulmonary transplantation for complex congenital heart disease, which was complicated by thrombotic thrombocytopenic purpura, quadrilateral limb gangrene, and stroke. In an effort to urgently obtain a venous access, a right femoral venous catheter was placed into the right groin in the cardiac care unit. The patient subsequently experienced severe hypotension and abdominal distension. Ultrasound and CT scans of the abdomen demonstrated a large retroperitoneal hematoma. Aggressive resuscitation failed to stabilize the patient. Angiography demonstrated an unusual bleeding source from an arterial collateral circulation in the right side of the pelvis, which was then successfully treated with embolization.
 ...
PMID:Retroperitoneal bleeding after inadvertent laceration of an arterial collateral during central venous catheterization; treatment with embolization. 1677 8

Acute mesenteric ischemia (AMI) is a catastrophic disorder of the gastrointestinal tract with high mortality. Few data on the characteristics of this disease in Iran are available. Patient records of public and private hospitals in Shiraz, southern Iran, with impression of acute abdomen, bowel gangrene or abdominal pain, and patients with risk factors for this disease, who were admitted between March 1989 and March 2005, were reviewed. Among the 10,000 patient records studied, 105 patients (mean age 57 years) with AMI were identified. The mortality rate was 50.4%. The most common symptom was abdominal pain (98.1%). Heart diseases were seen in 44.7% of cases. The mortality rate was lower in patients undergoing mesenteric angiography (p=0.014). In those patients in whom the site of lesion was identified, venous thrombosis was the most common type (41.9%). AMI is a common cause of acute abdomen especially in elderly patients, with venous thrombosis being the most common type.
 ...
PMID:Acute mesenteric ischemia: causes and mortality rates over sixteen years in southern Iran. 1940 57

Gangrene of the newborn or neonatal gangrene is very uncommon, and it usually involves the extremities. Neonatal gangrene seems to be more frequent in pregnancies related with spontaneous rupture of the amniotic sac leading to delayed delivery or dry labour. However, in most of the cases, no aetiological factor can be found. Foetal pressure necrosis and amniotic band sequence are two of the most common causes of this condition.Thrombosis, emboli, congenital heart disease, coagulopathy, sepsis and polycythaemia are some of the other aetiologic factors. Treatment of this condition is usually conservative and supportive. Conservative treatment includes adequate hydration, prevention from infections and allowing the involved area to demarcate in an aseptic environment. In some cases, surgical debridement and further reconstruction can be necessary. In order to prepare the wound bed for surgical closure after surgical debridement, vacuum-assisted closure (VAC) therapy can be a new, highly effective method in the treatment of newborn gangrene. In this article, a case of a neonatal gangrene treated with the application of VAC therapy is presented.
 ...
PMID:Vacuum-assisted closure therapy in newborn gangrene. 1958 Nov 34


<< Previous 1 2 3 Next >>