Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report on their experience of 300 open-heart operations performed in Abidjan for cardiac valve disease (149 cases), congenital cardiopathy (100 cases), endomyocardial fibrosis (40 cases) and other lesions. The operational method involved haemodilution, hypothermia, aortic clamping and cardioplegia. The death rate was 13.3%, mostly due to the severity of the condition prior to surgery. A number of specific points are discussed, including haemodilution without blood perfusions, surgery in patients with sickle-cell anaemia, cardiac valve surgery in children and surgery of endomyocardial fibrosis.
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PMID:[Open-heart surgery in tropical Africa. Results and peculiar problems of the 1st 300 cases of extracorporeal circulation performed in Abidjan]. 630 Aug 24

Echocardiographic assessment of cardiac function was made on 24 children with chronic renal failure of varying etiology and severity. In 20 patients without evidence of cardiac failure, parameters of left ventricular performance as represented by PEP/LVET and mean velocity of circumferential fiber shortening were within normal limits in the majority of patients. In addition, ejection fraction and shortening fraction were, in most children, within the 95% confidence limits for their age. In 4 patients who presented with congestive heart failure, marked left ventricular dilatation was noted in association with decreased shortening and ejection fractions and depressed mean velocity of circumferential fiber shortening. Also the PEP/LVET in these patients suggested the presence of a uremic cardiomyopathic condition. These studies, in addition to our own studies on children who have undergone fistula construction, hemodialysis, and transplantation, suggest that cardiac performance, in the majority of pediatric patients with end-stage renal disease, is well maintained and that the major factor involved in reducing exercise tolerance is the presence of uremic anemia. Only a minority of patients may develop severe uremic heart disease.
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PMID:Echocardiographic assessment of cardiac function in children with chronic renal failure. 658 80

Many patients with end-stage renal disease have now been maintained for 5 years or more with continuous ambulatory peritoneal dialysis (CAPD). Viewed initially as an experimental alternative to be used only when hemodialysis was not feasible, CAPD is now seen as the treatment of choice in an increasing number of situations. CAPD is suitable for self-care. The main concern in the early years--peritonitis--is now less frightening and less frequent (one episode occurring every 18 patient-months as compared with every 8 initially), and this has allowed chronic complications of CAPD, such as malnutrition and loss of the peritoneum's capacity for ultrafiltration, to come to light. As would be expected, among patients of advanced age and those who have heart disease or diabetes, survival rates tend to be lower than among other CAPD patients. However, hypertension seems to be more easily controlled, pre-existing anemia can be significantly ameliorated, and young children grow more normally than they do with hemodialysis. Diabetes-related changes in vision stabilize in most CAPD patients, and control of the blood glucose level is good; insulin is administered intraperitoneally. CAPD is thus showing itself to be a feasible form of long-term treatment for end-stage renal disease.
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PMID:Continuous ambulatory peritoneal dialysis: no longer experimental. 669 77

An increase in hemoglobin concentration characterizes the normal compensatory response to chronic tissue hypoxia. We observed no such increase in 42 chronically hypoxic patients with cystic fibrosis, in whom the mean concentration was 12.6 gm/dl; one third of the patients were anemic. Compared with patients with cyanotic heart disease, patients with cystic fibrosis did not have a compensatory increase in P50 or 2,3-diphosphoglycerate. Despite anemia, erythropoietin levels in patients with cystic fibrosis were not significantly different from normal control values. The growth of colony-forming units-erythroid in patients with cystic fibrosis was similar to that in control subjects, and there was no inhibition of growth with the addition of autologous serum. Erythropoietin sensitivity, determined by measuring the CFUe dose response curve, was normal in both patients and controls. Results of iron studies were consistent with iron deficiency in the majority of patients. Impaired absorption of iron was observed in six of 13 iron-deficient patients with cystic fibrosis. An inverse correlation between erythrocyte sedimentation rate and peak serum iron was obtained during the iron absorption study. Eight patients who underwent a therapeutic trial of iron demonstrated a 1.8 gm/dl rise in hemoglobin concentration. Two patients with previously documented iron malabsorption responded to parenteral iron therapy after failure to respond to oral supplementation. These studies demonstrate that patients with cystic fibrosis not only have an impaired erythroid response to hypoxia, but are frequently anemic. Their inadequate erythroid response to hypoxia results in part from disturbances in erythropoietin regulation and iron availability.
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PMID:Inadequate erythroid response to hypoxia in cystic fibrosis. 673 32

Echocardiograms were recorded from the inferior vena cava (IVC) in 45 subjects: 10 normal subjects, 8 patients with cardiac volume overload due to anemia, 4 with severe right heart failure, 6 with significant tricuspid incompetence (TI), 7 with pericardial effusion (PE) and 10 with left-sided cardiac disease. The IVC was readily identified on the echo recordings made 1 to 2 cm below the junction of the hepatic veins. In normal subjects a double wave form was present on the IVC echogram for each beat: the waves corresponded to the "a' and "v' waves of the IVC pressure pulse tracing. The IVC diameter decreased on inspiration (P less than 0.01), particularly of the "x' descent (P less than 0.001). In patients with severe right heart dysfuction, the IVC was dilated (TI: P less than 0.02; PE: P less thaN 0.003; CMO: P less than 0.001), having lost its waveform and with diminished respiratory variation. There was, however, considerable overlap between the normal subjects and the different patient groups. In two of the patients with tamponade, the IVC did not empty upon inspiration, and pericardiocentesis was followed by a return of the waveform and normal respiratory changes. IVC dimensions were normal in patients with anemia and in those with left heart disease. The results of the study showed that the echogram may provide simple and useful measurements of IVC size and function.
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PMID:Echocardiography of the inferior vena cava in healthy subjects and in patients with cardiac disease. 709 41

The authors study cardiac symptoms in malaria and consider four different situations. -Cardiac symptoms in 50 cases of acute malaria: these symptoms are functional in 14 p. 100 of the cases and objective in 40 p. 100 of the cases. Changes of repolarisation of the ECG recorded in 36 p. 100 of the cases may be related to hyperthermia (acting as a stress test) or to a malarial change in myocardium. - Cardiac symptoms in other malarial aspects: they are caused by a myocardiopathy resulting of malarial chronic anemia. - Cardiac symptoms during malarial fit in patients already affected by a cardiopathy: they are mainly blood hypopressure, persistent tachycardia and they are more a consequence of the hyperthermic strain applied to an already damaged heart than of malaria by itself. - Cardiac symptoms, related to the use of antimalarial drugs. They are obvious in acute voluntary intoxications, in excessive doses or in case of normal doses in patients with renal insufficiency or hypokaliemia.
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PMID:[The heart and malaria]. 714 94

Thirteen children with abnormal mitochondria in muscle tissue, and a progressive neurological disorder that affected the cerebrum, cerebellum, extrapyramidal system, vestibular system, retina, upper motor neuron, lower motor neuron, and musculature, are reported. Other signs and symptoms were short stature, diabetes mellitus, cardiopathy, hypoplastic anaemia, glomerulopathy, and renal tubular dysfunction. These symptoms may occur singly or in various combinations and the manifestation may differ even within the same family. The most common clinical picture was that of "ophthalmoplegia plus'. Occurrence in relatives varied from isolated symptoms to the complete syndrome with "ragged red fibres' and is not inconsistent with an autosomal dominant mode of inheritance with variable expressivity. Theories for the pathophysiological basis of this syndrome are discussed and the literature reviewed.
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PMID:Mitochondrial cytopathy. A multisystem disorder with ragged red fibres on muscle biopsy. 730 11

Hemoglobin (Hb), hematocrit (Hct) and mean corpuscular hemoglobin concentration (MCHC) were determined in 36 acyanotic and 38 cyanotic patients with congenital heart disease. Serum iron (SI) was also determined in 16 cyanotic patients. Patients were classified as follows: Gp I, 0.5-5 years old and Gp II, 6-12 years. In acyanotic patients, anaemia (Hb 11 gr%) was present in 35% for Gp I and 18.7% for Gp II (Hb 11.5 gr%), a figure which is similar to the general Greek children's population. In cyanotic patients which have normal or high Hb concentration, when SI was used as an index, anaemia (SI 60 g%) was found in 37.5% for Gp I and 12.5% for Gp II. Furthermore, when using as index the MCHC the percentage of anaemia (MCHC 31%) was further increased in those patients (44% for Gp I and 23.8% for Gp II). Four cyanotic infants with MCHC 31% developed cerebrovascular accidents. The data show 1) that the MCHC is a convenient and accurate index of iron deficiency anaemia in children with cyanotic heart disease and 2) that the incidence of hypochromic anaemia is high in cyanotic patients.
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PMID:[Incidence of anaemia in congenital heart diseases (author's transl)]. 734 22

The globes from two elderly women who underwent enucleation for malignant melanoma of the choroid showed cavernous degeneration of the optic nerve. Both individuals had prominent optic cups and a strong family history of severe cardiovascular disease; one patient also had mild anemia and substantial arteriosclerotic heart disease. Neither patient showed any clinical or histologic evidence of glaucoma. It is proposed that cavernous degeneration of the optic nerves in some patients may represent an aging change associated with generalized arteriosclerosis. Individuals with large optic cups may be more at risk of developing this condition.
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PMID:Nonglaucomatous cavernous degeneration of the optic nerve. Report of two cases. 735 88

There is controversy in the medical literature regarding the significance of "sickle cell cardiomyopathy." In an attempt to clarify this, we studied 14 patients with sickle cell anemia (age range 16 to 36 years) using simultaneous echocardiography and phonocardiography. The values of systolic time intervals and echocardiographic indices of left ventricular performance were similar to those reported for normal subjects and those with comparable degrees of anemia. We confirm a previous report of normal left ventricular function at rest in patients with sickle cell anemia and concur with the suggestion that a concomitant heart disease be considered in these patients when cardiac failure supervenes.
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PMID:Left ventricular function in sickle cell anemia: a noninvasive evaluation. 736 Nov 40


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