Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018799 (heart disease)
 34,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Excessive and chronic ethanol consumption exerts deleterious and diffused effects on the myocardium, independent of coronary atherosclerosis, arterial hypertension, valvular disease or congenital heart disease. Although the effects of chronic alcoholism on systolic cardiac function are well known, diastolic involvement has been evaluated only partially. This short review summarizes the experimental and clinical evidence for alcohol-induced cardiac disease.
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PMID:[Alcohol-induced cardiac disease]. 1929 16

While prospective data is scant, the advisability of magnesium measurement appears to be convincing in selected circumstances. Electrolyte abnormalities, mainly hypokalemia and hypomagnesemia, are associated with an increased risk for developing cardiac arrhythmias, however, conflicting opinions remain. If performed on all patients undergoing non-cardiac surgery, magnesium measurement would add considerably to health care costs; however, if limited to patients identified as high risk by the above parameters, the additional cost per patient is in keeping with other standard tests. Given the low cost of testing and replacement, preoperative magnesium measurement appears reasonable in patients with structural heart disease, diabetes, chronic alcoholism, and chronic (loop) diuretic use. When high risk patients are undergoing high risk operations, the low cost of measurement and replacement appears particularly cost-effective, whether it reduces morbidity and prolonged hospitalization from atrial fibrillation or mortality from sustained ventricular arrhythmias. Until additional data becomes available, use of this simple test in patients likely to manifest hypomagnesemia who are at elevated risk of cardiac tachyarrhythmias and cardiac complications following non-cardiac surgery seems prudent.
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PMID:When should serum magnesium be measured prior to non-cardiac surgery? 1929 17

The commonest forms of heart disease in sub-Saharan Africa are chronic rheumatic heart disease, dilated cardiomyopathy, pulmonary heart disease, infectious forms of heart disease including chronic, constrictive and infective endocarditis, genetic forms of heart disease and arrhythmias. Malnutrition, with cardiac manifestations such as beriberi, and alcoholism also play a part. Ischaemic heart disease in sub-Saharan Africa at present affects mainly the small, Westernised white population. Heart disease is a less important cause of morbidity and mortality than many other infectious diseases but is likely to escalate in the next generation(s). The changing demographic picture dictates the way in which funds for research, prevention and treatment must be channelled to best advantage. A concerted effort must be made by cardiologists of African countries to arrest the advance of heart disease, and a declaration outlining these strategies has been endorsed by the Pan-African Society of Cardiology (PASCAR).
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PMID:Strategies for heart disease in sub-Saharan Africa. 1962 70

Alcoholism has been associated with a wide range of pathologic conditions, including alcoholic heart disease (AHD). Because AHD may be associated with oxidative stress, antioxidant compounds, such as N-acetylcysteine (NAC) could be useful to control the damage done by alcohol (ethanol) consumption. To investigate the NAC effects on alcoholism and alcohol abstinence, initially, 30 male Wistar rats were divided into two groups: (C, N=6) given standard chow and water; (E, N=24) receiving standard chow and aqueous ethanol solution in semi-voluntary research. After 30 days of ethanol-exposure, (E) group was divided into four subgroups (N=6/group):(E-E) continued drinking 30% ethanol-solution; (E-NAC) drinking ethanol-solution containing 2g/L NAC; (AB) changed ethanol solution to water; (AB-NAC) changed ethanol to aqueous solution of 2g/L NAC. After 15 days of the E-group division, E-E rats had lower body weight and feed efficiency, as well as higher energy-expenditure resting metabolic rate (RMR)/body weight and VO(2) consumption/surface area. These calorimetric changes were reflected on the cardiac tissue. E-E rats had higher heart weight/body weight ratio and myocardial lipid hydroperoxide (LH), indicating AHD with hypertrophy and oxidative stress. Myocardial superoxide dismutase was higher, whereas glutathione-peroxidase (GSH-peroxidase) was lower in E-E rats than in C. The higher myocardial hydroxyacyl coenzyme-A dehydrogenase (OHADH), OHADH/citrate synthase (CS), and lactate dehydrogenase (LDH)/CS in E-E rats indicated higher fatty acid degradation relative to aerobic metabolism predisposing the lipotoxicity. AB rats had lower RMR/body weight than E-E, normalized myocardial oxidative stress, and energy metabolism. E-NAC and AB-NAC had lower RMR/body weight, myocardial LH, LDH/CS, and higher GSH-peroxidase than E-E and AB, respectively, demonstrating lower oxidative stress and higher myocardial carbohydrate oxidation. In conclusion, the present study brought new insights on alcohol consumption and AHD because ethanol-exposure enhanced energy-expenditure and induced a number of calorimetric changes, which were reflected in body weight and myocardial lipotoxicity. NAC preventing ethanol-induced calorimetric changes and reducing myocardial oxidative stress enhanced carbohydrate oxidation, thus optimizing myocardial energy metabolism in both alcoholic and abstinence condition.
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PMID:Alcoholism and alcohol abstinence: N-acetylcysteine to improve energy expenditure, myocardial oxidative stress, and energy metabolism in alcoholic heart disease. 2000 43

Healthy-appearing hair is a sign of excellent general health, as well as good hair care practices. Most healthy individuals have adequate nutrients in their diet; however, many people do not have access to good nutrition, and others have medical illnesses that predispose them to nutritional deficiency. This is often reflected in changes of scalp and, at times, body hair. Malnutrition, congenital heart disease, neuromuscular disease, chronic illnesses, malignancy, alcoholism, and advanced age can cause hair to change color, be weakened, or lost. Recognition of the populations at risk for vitamin deficiency is the first step to their detection. Changes in skin and hair can provide clues to the presence of an underlying vitamin deficiency.
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PMID:Nutrition and hair. 2062 Jul 58

Considerable evidence supports the existence of racial disparities in incidence, mortality, and morbidity related to stroke. Awareness of risk factors could substantially lower the probability of stroke incidence. Awareness of stroke warning signs and treatment options could significantly alter the outcome of a stroke if patients immediately seek emergency help. This article examines the disparities in awareness of stroke risk factors, stroke signs, and action to be taken when stroke occurs. Survey results from 422 Caucasian Americans and 368 African Americans in West Virginia were analyzed. Significant disparities in recognition of cholesterol, smoking, prior stroke, and race as stroke risk factors were observed. The study also found a significant and substantial difference in awareness of stroke signs. There was also a significant difference in the way African Americans and Caucasians would respond to a stroke. The study found no evidence of disparities in recognition of stroke risk factors, such as hypertension, diabetes, heart disease, obesity, alcoholism, and family history.
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PMID:Racial disparities in stroke awareness: African Americans and Caucasians. 2148 12

Diabetes has emerged as a major threat to worldwide health. The increasing incidence of diabetes in young individuals is particularly worrisome given that the disease is likely to evolve over a period of years. In 1972, the existence of a diabetic cardiomyopathy was proposed based on the experience with four adult diabetic patients who suffered from congestive heart failure in the absence of discernible coronary artery disease, valvular or congenital heart disease, hypertension, or alcoholism. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemiainduced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. In this review, we provide the emergence of experimental evidence supporting antioxidant supplementation as a cardioprotective intervention in the setting of diabetic cardiomyopathy.
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PMID:Diabetic cardiomyopathy and oxidative stress: role of antioxidants. 2190 60

Alcohol liver disease (ALD) is a major health problem worldwide. After heart disease and cancer, alcoholism is the world's biggest health problem and most deaths attributed to alcoholism are caused by cirrhosis of the liver. Results show that LlVINA, a poly herbal liquid formulation was effective in blunting ethanol-induced enhanced activities of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), level of serum bilirubin (both total and direct), blood urea nitrogen (BUN), serum total cholesterol, liver weight loss and was also effective in reducing ethanolinduced lipid peroxidation. Results of hepatocellular damage caused by ethanol and its recovery by LIVINA, suggest that itmight be consideredas apotentialsource of naturalhepatoprotective agent.
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PMID:Protective effect of livina, a polyherbal liquid formulation against ethanol induced liver damage in rats. 2255 15

F Scott Fitzgerald spent the 1930s writing about illness themes while he struggled with tuberculosis, insomnia, alcoholism, heart disease and the mental illness of his wife Zelda. During this decade, Fitzgerald published six stories that prominently feature hospitals and healthcare professionals. These stories, the 'doctor-nurse stories', along with nine additional published stories that touch upon medical themes have not previously been investigated as a thematic grouping. This paper explores the 1930s stories in the context of Fitzgerald's life and career in order to highlight his significant yet previously undervalued contribution to the canon of illness literature and his work's relevance to the field of literature and medicine.
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PMID:A lost decade: exploring F Scott Fitzgerald's contribution to the illness canon through the doctor-nurse series and other healthcare stories of the 1930s. 2262 6

There is a mutual interaction between the function of the heart and the liver and a broad spectrum of acute and chronic entities that affect both the heart and the liver. These can be classified into heart diseases affecting the liver, liver diseases affecting the heart, and conditions affecting the heart and the liver at the same time. In chronic and acute cardiac hepatopathy, owing to cardiac failure, a combination of reduced arterial perfusion and passive congestion leads to cardiac cirrhosis and cardiogenic hypoxic hepatitis. These conditions may impair the liver function and treatment should be directed towards the primary heart disease and seek to secure perfusion of vital organs. In patients with advanced cirrhosis, physical and/or pharmacological stress may reveal a reduced cardiac performance with systolic and diastolic dysfunction and electrophysical abnormalities termed cirrhotic cardiomyopathy. Electrophysiological abnormalities include prolonged QT interval, chronotropic incompetance, and electromechanical uncoupling. No specific therapy can be recommended, but it should be supportive and directed against the heart failure. Numerous conditions affect both the heart and the liver such as infections, inflammatory and systemic diseases, and chronic alcoholism. The risk and prevalence of coronary artery disease are increasing in cirrhotic patients and since the perioperative mortality is high, a careful cardiac evaluation of such patients is required prior to orthotopic liver transplantation.
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PMID:Interactions of the heart and the liver. 2385 73


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