Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of intracranial complication in patient with cephalgia and short period of the temperature without signs of sharpening chronic otitis is reported. At the time of the operation epidural abscess of fossa cranial posterior, perisinusal abscess and thrombus of sigmoid sinus, abscess in transverse sinus were found.
Otolaryngol Pol 1995
PMID:[Thrombosis of the sigmoid sinus and transverse sinus with an unusual course]. 764 4

The authors present a case of Morgagni-Morel-Stewart syndrome with violent headaches predominant in the clinical course. Surgical removal of hypertrophic frontal bone followed by dura and bone reconstruction was performed. The pains ceased immediately after the operation. The authors discuss surgical treatment especially in cases with high intensity headaches.
Neurol Neurochir Pol
PMID:[A case of Morgagni-Morel-Stewart syndrome with violent headaches predominant in the clinical course treated surgically]. 765 98

In the cerebrospinal fluid of two groups of patients with subacute sclerosing panencephalitis (SSPE), the determinations of LTB4 and LTC4 leukotriene concentrations were performed by radioimmunoassay (RIA). In the first group of 10 patients with chronic SSPE (from 2 to 11 years), the LTB4 and LTC4 levels were 94.8 +/- 17.0 and 97.4 +/- 16.8 pg/ml respectively, and were significantly higher than those in six patients with discopathy, epilepsy and headache (p < 0.01). In the second group of 10 patients with beginning SSPE (disease duration from 1 to 11 months) LTB4 level was lower (was not different from that in the control group), while LTC4 concentration was 97.6 +/- 10.8 pg/ml and again was significantly raised. Higher LTB4 and LTC4 levels in the cerebrospinal fluid of patients with SSPE indicate that these compounds participate in chronic inflammatory reaction around cerebral veins.
Pol Tyg Lek
PMID:[Leukotrienes in cerebrospinal fluid of patients with subacute sclerosing panencephalitis]. 765 22

The authors present a case of teratoma adultum of unusual intrasellar localisation. The tumour was surgically treated with excellent result. It was confined to sella turcica and partially invaded the suprasellar region. It produced headache, mild bitemporal hemianopsia and did not cause clinically evident hormonal disturbances.
Neurol Neurochir Pol
PMID:[A case of intrasellar teratoma]. 787 Feb 69

Headaches belong to the most frequent sufferings. According to certain most modern epidemiological studies about 20% of adults have recurrent headaches, among them particularly migraine and tension headache. In recent years the interest in these conditions had increased resulting in a great number of research works. A great role is played by the International Headache Society, and the newly formed European Federation of Headaches. In 1988 a universally accepted classification, and diagnostic criterias were elaborated and have been accepted by the Polish neurologists. Tens or research centres are studying the problems in this field. The main directions of studies are-the role of neurotransmitters, the vascular system of the head, the mechanisms of autonomic regulation, the role of neurogenic bland inflammation in the generation of pain, and the psycho-emotional factors. A number of new clinical forms of headache have been described. Therapeutic possibilities have also increased (beta-blockers, calcium blockers, serotonin receptor drugs, eg. sumatriptan, microsurgery of neuralgias etc). This opens a new period for satisfactory advances in that rather marginal, as yet, area.
Neurol Neurochir Pol 1994
PMID:[Present problems of migraine and similar headaches]. 791 20

The direct cytostatic and cytotoxic effect of recombinant human TNF alpha on human tumor xenografts encourages further clinical investigation. The most commonly observed toxicities (even after low doses), include constitutional symptoms, such as fever, chills, headache, hypotension and local inflammatory reaction at the injection point. Pharmacokinetic study has shown a rapid clearance following iv. infusion (half time 10-30 min). The phase I study has not revealed any beneficial effect so far (2-4% response), which may be due to low doses. Now the phase II investigations has started incorporating the combined application of TNF with other cytokines and cytostatics as well. The preliminary results seem to be promising.
Acta Haematol Pol 1994
PMID:[Recombinant human tumor necrosis factor alpha (TNF): preclinical studies and results of early clinical trials]. 806

The occurring frequency of 14 most common chemotherapy and anti-nausea drug side-effects was examined. The studies were performed on 29 women with ovarian cancer treated by total number of 125 chemotherapy courses (schedule PAC and Acy) and additionally, in order to eliminate nausea caused by the chemotherapy, by anti-nausea drugs (Zofran, Solu-Medrol, Droperidol, Metoclopramide + Fenactil, Torecan). Zofran caused the fewest number of side-effects, solu-medrol inhibited nausea and vomiting significantly, however it caused many side-effects such as flush on a face, restlessness, incitement and headaches. Torecan did not prevent patients from vomiting. The greatest number of side-effects was observed after droperidol and metoclopramide + fenactil treatment.
Ginekol Pol 1993 Sep
PMID:[Side effects of drug treatment for ovarian cancer after administration of antiemetic drugs]. 814 54

Interferon-gamma (IFN-gamma) is produced by activated T cells and probably by NK cells. Its production can be induced by mitogens, antigens and other molecules. IFN-gamma interacts with cells by binding to specific membrane receptors. IFN-gamma--1b is an Escherichia coli--derived recombinant DNA product, which has biological activity identical to natural human IFN-gamma. This IFN type is a more potent immunomodulator than IFN-alpha and IFN-beta. Long term treatment with a therapeutic dosage of IFN-gamma--1b produces a significant reduction in the incidence of serious infections in patients with chronic granulomatous disease. This cytokine can be also useful in the treatment of patients with visceral leishmaniasis, Epstein-Barr virus infections, lepromatous leprosy and other infectious diseases. Phase I and II studies have demonstrated it to be capable of producing antitumor effects, especially in metastatic renal cell carcinoma and some hematologic malignancies. Clinical trials have suggested efficacy of IFN-gamma in the treatment of severe atopic dermatitis and rheumatoid arthritis. The most common adverse reactions are fever, headaches and erythema at the injection site.
Acta Haematol Pol 1994
PMID:[Biological properties and clinical applications of interferon gamma (IFN-gamma)]. 820 10

A primary HIV infection presenting as an acute viral syndrome in 31-years-old male drug addict is described. Two weeks after the probable infection the patient presented with fever, sweats, anorexia, vomiting, diarrhoea, myalgia, arthralgia, headaches, macular eruption, generalized lymphadenopathy, paresthesia and thrombocytopenia. These symptoms lasted 7 weeks. The immune abnormalities included an increase of CD8+ lymphocyte percentage resulting in decrease od CD4/CD8 ratio. HIV antigenemia was found 4 weeks after the presumed exposure whereas anti-HIV became detectable 2 weeks later.
Pol Arch Med Wewn 1993 Sep
PMID:[Concomitant symptom syndrome of primary HIV infection]. 828 48

The premenstrual syndrome occurs in the second phase of period and strain, sensitivity, nervousness, anxiety, sleeplessness, headaches, sickness, swollen breasts are the typical symptoms of the syndrome. 143 high school girls have been subjected to the anonymous questionnaire. They were divided into two groups: A--those who showed the symptoms of the premenstrual syndrome, and B--those who did not shown the symptoms. The results of the survey are presented in two sub-scales: fear-condition and fear-feature.
Ginekol Pol 1993 Aug
PMID:[An attempt to apply Spielberg's self-assessment questionnaire in cases of premenstrual syndrome in girls]. 837 20


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