Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pathophysiology of migraine and its associated perceptual symptoms remains controversial. We recorded long-latency auditory event related potentials (AEPs) in 30 unmedicated patients with common migraine, and compared them to 20 controls. 1,000 and 3,000 Hz tones were presented in an 80:20 ratio at 75 dB SL. 200 responses were recorded and replicated from Cz-A1 + A2, with filter band-pass of 1-100 Hz, analysis time of 1,000 ms., and interstimulus interval of 1.1 second. N100, P200, and N200 ERP components did not differ in latency or amplitude between migraine patients and controls. P300 was longer in latency among those with common migraine, and P300 amplitude was significantly reduced (P greater than 0.05). These findings suggest that migraine may have a central mechanism, and that migraineurs may have a difference in task involvement or perception which may influence their clinical course and response to therapy.
Headache 1989 Apr
PMID:Long-latency auditory event related potentials in migraine. 271 75

The event-related potential P300 has been studied in 15 migraine without aura sufferers, and in 15 episodic tension-type headache sufferers, during pain-free periods and during spontaneous headache attacks. There were no variations of potential, either of P3 latency or N2-P3 amplitude, in either group during the interictal period. Similarly, there were no variations of the P300 parameters in the group of tension-type headache subjects during headache attacks; by contrast, a significant elongation of latency (P < 0.01) and an increment of N2-P3 wave amplitude (P < 0.002) was observed in the group of migraineurs. The authors discuss the data in accordance with the etiopathogenic theories of migraine and the hypothesis that acetylcholine and norepinephrine are the neurotransmitter able to affect the event-related potential P300, which reflects cerebral activity during sensory information processing and analysis.
Headache 1995 Apr
PMID:The event-related potential P300 during headache-free period and spontaneous attack in adult headache sufferers. 777 78

There is strong evidence for a loss of habituation during cognitive processing in migraine as measured by P300 and contingent negative variation in adults. Event-related potentials evoked by an oddball paradigm have not yet been studied in children and adolescents suffering from different primary headache types. We recorded visually evoked event-related potentials (two consecutive trials, 200 stimuli each) in 48 children and adolescents suffering from migraine without or with aura, from episodic tension-type headache, and from ergotamine-induced headache and analyzed the latencies, amplitudes, and reaction times. No statistically significant differences were noted between all headache types and healthy controls analyzing the averaged parameters for the whole measurement. However, a highly significant loss of cortical habituation as measured by P300 amplitude and latency could be observed in migraine without and with aura by analyzing the first and the second trial of measurement separately. This phenomenon increased with age and could not be seen in healthy controls, or patients with tension-type headache or ergotamine-induced headache. Our data suggest a specific cognitive processing in migraine even in children and adolescents. Measurement of the habituation effect in P300 latency and amplitude provides a specific method to differentiate between primary headache types in childhood and adolescence.
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PMID:Event-related potentials (P300) in primary headache in childhood and adolescence. 970 80

In this randomized, double-blind, three-period crossover trial, 24 healthy volunteers without migraine received zolmitriptan 5 mg, dexfenfluramine 15 mg or placebo orally. At 2, 6, and 24 h postdose, auditory stimuli of 1000 Hz (nontarget tone) and 2000 Hz (target tone) were randomly and binaurally presented in an active oddball paradigm (4:1 ratio). Cortical auditory evoked responses were recorded for 500 msec poststimulus. Plasma concentrations of zolmitriptan and a 17-lead quantitative EEG were assessed at the same timepoints. Relative to placebo, zolmitriptan reduced the maximum absolute amplitude, amplitude difference (from nontarget tone noise) and area under the curve of the cortical auditory target tone event-related potential (P300 ERP). The most dramatic effect of zolmitriptan was to diminish the point estimate of noise during the 200-400 msec poststimulus epoch. The effect of zolmitriptan appeared concentration dependent. The latency of the P300 ERP was unaffected by zolmitriptan and there was no clinically significant effect on the EEG. Modification by zolmitriptan of the cortical electrical activity evoked by auditory stimuli confirms a central action of this drug in humans, which appears to affect cortical information processing without global alteration of the quantitative EEG.
Cephalalgia 1999 Mar
PMID:Effects of zolmitriptan (Zomig) on central serotonergic neurotransmission as assessed by active oddball auditory event-related potentials in volunteers without migraine. 1021 35

To examine the cognitive processing differences in chronic and episodic pain sufferers, auditory event-related potentials (P300 or P3) were recorded in two consecutive trials from 23 chronic lower back pain patients, 22 episodic tension-type headache sufferers, and from 23 age- and sex-matched healthy persons. P3 latency and amplitude showed no difference between groups at first trial. Considering P3 latency habituation, healthy controls and episodic tension-type headache sufferers showed a significant change of P3 latency whereas lower back pain sufferers failed. Comparing the amount of habituation lower back pain sufferers stood clearly apart from healthy controls. Although there was a remarkable increase of P3 latency in episodic tension-type headache sufferers, the amount of habituation was not statistically different than it was in lower back pain sufferers. Significant P3 amplitude habituation was observed only in healthy controls. Actually, episodic tension-type headache sufferers also showed some degree of habituation, which was not statistically remarkable. The amount of amplitude habituation was not different between groups. No correlation was observed between P3 habituation and age, disease duration and symptom severity. These results may point to a disturbed attentional processing in chronic pain sufferers. Our findings suggest that in spite of a similar cortical information processing, the neurocognitive networks related with decision making and memory processing seem to work differently in chronic pain sufferers from those in episodic pain sufferers in repeating tasks. Taking into consideration the reported P3 habituation abnormalities in chronic migraine patients we can say that not the location of pain but rather its temporal pattern may have a role in disturbed attentional processing.
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PMID:The auditory event related potentials in episodic and chronic pain sufferers. 1203 11

The acoustically evoked cortical potentials of 20 migraine patients were investigated using a combined conditioning-testing and oddball paradigm. The short- and long-term habituation results of the P50 and P300 waves were compared with 16 healthy subjects. Migraineurs were characterized by a sensory gating deficit of the P50 wave (reduced short-term habituation) in the non-target condition and a reduced long-term habituation of the P300 wave in the target condition. The study describes disturbances of information processing on the automatic and cognitive levels in migraine patients and emphasizes the role of sensory gating and orienting response in migraine pathogenesis.
Cephalalgia 2003 Sep
PMID:What kind of habituation is impaired in migraine patients? 1295 Mar 76

Clinical phenomenon of migraine aura and comparison of main types of migraine were studied, using a method of visual evoked potentials (VEP) in 46 patients with migraine with aura, in 30--without aura and in 10 healthy controls. Common features as well as differences were revealed. Patients with migraine with aura were distinguished by significantly higher mean amplitudes of P300 component and by more frequents unstable VEP registration as compared to those without aura. Qualitative changes of amplitude and configuration and reduction of latent P300 period concomitant with headache side had the same frequency in both groups. In intra-group clinico-neurophysiological analysis, in regard to visual aura phenomena, the attacks with simple phenomena were the most severe in frequency, combinations with other aura symptoms, clinical and neurophysiological signs of visual system hyperexcitability.
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PMID:[Clinico-neurophysiological features of migraine with and without aura]. 1462 87

Cognitive processing was investigated interictally in 18 children with migraine without aura and 18 age-matched controls by measuring event-related potentials (ERPs) and reaction times (RTs) during an acoustic oddball paradigm. Results showed that N100 amplitude evoked by frequent stimuli was significantly smaller in patients compared with controls. Habituation of target P300 amplitude was observed in patients but not in controls. Mean RTs were equivalent in the two groups, but migraine children made more errors than controls.
Cephalalgia 2004 Jul
PMID:Auditory event-related potentials and reaction times in migraine children. 1519 98

Fifteen healthy individuals and 17 patients with episodic exertional headaches were examined before and after treatment with citalopram using P300 event-related potentials. Unlike healthy controls, patients with headaches before treatment displayed an increase in P300 amplitude and the loss of its habituation, which correlated with a decrease in cognitive functions. The treatment lowered the degree of pain and vegetative syndromes, normalized P300 parameters, and improved cognitive functions. The use of P300 method may be an additional criterion of the effectiveness of therapy in patients with exertional headaches.
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PMID:[The use of P300 event-related potentials in the evaluation of the effectiveness of therapy of episodic exertional headaches]. 1733 78

In the study knowledge about cognitive event related potentials, particulary P300 potential was presented. It was shown as a objective and non-invasion method of estimate of cognitive functions, allowing on estimate of memory, taking decision and degree of concentration. Their origin in state of health and many disturbances and developmental diseases of nervous system were discussed. Difficulty in their registration and interpretation in this age has shown. Endogenous evoked potentials position in neuropediatrics was discussed, especially for diagnostics of neurologic and psychiatric diseases, as well as for monitoring course and treatment of these diseases. The diagnostic value of P300 for estimate of change of cognitive function in some syndromes and development diseases as epilepsy, tumour and brain injury, headache, demyelinisation, metabolic and degeneration diseases and progressive and non progressive encephalopathies was revealed. It was reminded of requirement of practice complex research of different potentials as well as application of new stimulation methods.
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PMID:[Cognitive event related potentials in neuropediatrics]. 1734 26


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