Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non-typhoid salmonellosis remains a common infective illness. We studied 77 consecutively admitted children aged 1 month to 15 years in order to determine frequency of antecedents, the strain of the isolated organisms, clinical findings, frequency of complications and the adequacy of management. The presentation and severity of the illness were compared between younger than two and older children. Salmonella typhimurium was isolated in 65% of the cases. Two thirds of the tested strains were multiresistant to antibiotics. Non-typhoid salmonellosis usually occurred in the form of acute gastroenteritis: in only 4% of the cases it presented as pyrexia of unknown origin without gastrointestinal symptoms. 30% of the cases had been exposed to one or more antimicrobial agents within four weeks before the date of their stool culture. Only 30% had been breast fed. Previously diagnosed cow's milk protein intolerance resulted to be present in 14% of the less than two years old children (p < 0.02). Abdominal pain and headache were found more frequently in older children (p < 0.02). Protein C reactive values were significantly higher in this age group (p < 0.05). 25% of the children were mildly or moderately dehydrated. Hypernatremia was uncommon. 31% of the cases were treated with antibiotics: the antimicrobial treated children presented diarrhoea for longer period (p < 0.05) and they remained admitted for longer time (p < 0.00).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Clinico-epidemiological observations of 77 pediatric cases of infection with non-typhi salmonellae]. 807 87

We report clinical findings, risk factors and neurological and cognitive long-term outcome in three Italian children aged 7, 8 and 5, respectively, who experienced cerebral venous sinus thrombosis (CVST). All children presented with headache, associated to nausea, vomiting and papilloedema. None suffered from epileptic seizures. In two of them a paresis of the sixth cranial nerve with diplopia was found. Diagnosis was confirmed by magnetic resonance imaging angiography (angio MRI) in all cases. In all patients plasma levels of protein C, protein S, antithrombin III (AT III), antiphospholipid antibodies (ApA) and homocysteine were detected. Furthermore, factor V Leiden mutation, prothrombin mutation G20210A and MTHFR mutation were searched for. A Protein C reduction was detected in all patients at onset; this finding, however, was not confirmed at follow-up in all of them. At one-year follow-up, neurological examination was normal in all children and neuropsychological assessment, aimed at excluding linguistic and non-linguistic cognitive deficits, revealed normal performances in two of them. In the third child, cognitive assessment confirmed a previously diagnosed developmental dyslexia.
 ...
PMID:Cerebral venous sinus thrombosis in childhood: clinical aspects and neurological and cognitive long-term outcome in three cases. 1562 88

The spectrum of presentation of intracranial hypotension is clinically perplexing. We report a case of 31-year-old post-partum woman who underwent an uneventful caesarean section under spinal anesthesia. From the second day of surgery she developed postural headache, the headache lost its postural character after few days. She then developed seizures and ataxic hemiparesis. Magnetic resonance imaging showed features of severe intracranial hypotension in the brain and the spinal cord, and magnetic resonance venography showed cortical vein and partial superior sagittal sinus thrombosis. Prothrombotic (etiological) work-up showed Protein C and S deficiency. She responded to anticoagulation therapy and recovered completely. On review of literature two distinct groups could be identified obstetric and non-obstetric. The non-obstetric group included patients who underwent diagnostic lumbar puncture, intrathecal injection of medications and epidural anesthesia for non-obstetric surgeries. Poor outcome and mortality was noted in non-obstetric group, while obstetric group had an excellent recovery.
...
PMID:Cerebral venous thrombosis in post-lumbar puncture intracranial hypotension: case report and review of literature. 2462 3