Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Drug
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Target Concepts:
Gene/Protein
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Query: UMLS:C0018681 (
headache
)
56,091
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pavetta indica
L. is used in traditional medicine for the treatment of various diseases including hemorrhoids,
headache
, urinary conditions, ulcerated nose, and dropsy. However, no study has evaluated the anticancer effect of
P. indica
L. In this study, we found that a methanol extract of the leaves and branches of
P. indica
L. (
MEPI
) caused cellcycle arrest at the sub-G1 phase and induced apoptosis, as indicated by the activation of caspase-8, -3, -7, and c-PARP. Western blotting revealed that
MEPI
significantly reduced the levels of markers of the epithelial-mesenchymal transition, such as Vimentin, Snail, Slug, and matrix metallopeptidase 9. Notably, the expression of multidrug resistance-associated protein 1 in triple negative breast cancer (TNBC) was significantly decreased by
MEPI
. Moreover, the co-treatment with
MEPI
and doxorubicin resulted in a synergistic reduction in cell viability.
MEPI
also induced radiation sensitization of TNBC cells. Gas chromatography-mass spectrometry analysis revealed that 5,6-dehydrokawain (DK) is the major constituent of
MEPI
. Interestingly, DK exerted significant anti-invasive and anti-metastatic effects. Our results provide a strong rationale for investigating the molecular mechanisms of action of
MEPI
in TNBC.
...
PMID:Methanol Extract of Aerial Parts of
Pavetta indica
L. Enhances the Cytotoxic Effect of Doxorubicin and Induces Radiation Sensitization in MDA-MB-231 Triple-Negative Breast Cancer Cells. 3121 82
