Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mefloquine was compared with sulfadoxine-pyrimethamine for safety and efficacy in a randomized, double-blind clinical trial in adult males from a malaria-endemic area of Brazil. A total of 99 oligosymptomatic and symptomatic volunteers with Plasmodium falciparum parasitaemia took part in the trial; 49 were given 1000 mg of mefloquine and the remainder received 1500 mg of sulfadoxine plus 75 mg of pyrimethamine, in a single oral dose.Mefloquine was 100% successful in clearing parasitaemia within 7 days; there were no recrudescences. Sulfadoxine-pyrimethamine was less successful; 35 cases showed an S-type response, 8 an RI response, 3 an RII, and 2 an RIII response. The side-effects of mefloquine were mild and transient and included headache, nausea, vomiting, dizziness, and diarrhoea. A satisfactory weight gain and rise in haemoglobin level were seen in both groups.
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PMID:A phase II clinical trial of mefloquine in Brazilian male subjects. 636 Apr 1

The knowledge and practices on malaria treatment measures were assessed among 1400 pregnant women in semi-urban and rural communities (Akomoje, Iberekodo, Osiele and Sabopapamaru) of Abeokuta, Nigeria in 2006. Data was collected using structured questionnaires and focus group discussions. The largest proportion (41%) of the respondents was in the age group 21-25years. About three quarters (74%) of the women were multigravids. Sixty-five percent of the women had between three to four episodes of malaria per year. According to the respondents, symptoms associated with malaria in pregnancy included abdominal pains and foetal weakness due to reduced kicks (53%), body pains and headaches (27%) and anaemia (20%). Sixty-eight percent of the pregnant women utilized herbs for treating symptoms associated with malaria due to its effectiveness and suitability and not due to financial constraint or lack of access to health facility. Though most women utilized herbs, 32% relied more on the use of antimalarials. Sulfadoxine-pyrimethamine was the preferred antimalarial during pregnancy at the 2nd and 3rd trimesters. Only 15% of the women were using insecticide treated mosquito nets for personal protection. The majority (77%) of respondents used nylon net to screen their windows off mosquitoes. Since malaria poses adverse effect on the mother and developing foetus, health education becomes very essential to the traditional birth attendants and the women who patronize them. Pregnant women who attend traditional birth homes should be encouraged to also attend orthodox antenatal clinics, in order to receive proper and adequate treatment against malaria for themselves and the foetus.
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PMID:Knowledge and practices on malaria treatment measures among pregnant women in Abeokuta, Nigeria. 1940 84