Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective was to assess acute effects from controlled exposure of volunteers to 2-ethyl-1-hexanol, a volatile organic compound that is often found in indoor air. Sixteen males and fourteen females were in random order exposed to 1 mg/m(3) of vapors of 2-ethyl-1-hexanol or to clean air (control exposure) in an exposure chamber during 2 h at rest. The subjects performed symptom ratings on Visual Analog Scales. During exposure to 2-ethyl-1-hexanol subjective ratings of smell and eye discomfort were minimally but significantly increased. Ratings of nasal irritation, throat irritation, headache, dyspnoea, fatigue, dizziness, nausea, and intoxication were not significantly affected. No exposure-related effects on measurement of blinking frequency by electromyography, measurement of the eye break-up time, vital staining of the eye, nasal lavage biomarkers, transfer tests, spirometric and rhinometric measures were seen. No differences in response were seen between sexes or between atopics and non-atopics. Practical Implications It is important to assess acute effects in volatile organic compounds like 2-ethyl-1-hexanol. 2-ethyl-1-hexanol is often found in indoor air generated by degradation of plastic building materials or in new buildings. There are associations between 2-ethyl-1-hexanol in indoor air and respiratory effects, eye irritation, headache, and blurred vision. A controlled chamber exposure study in acute effects was performed. In conclusion, this study showed weak subjective symptom of irritation in the eyes.
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PMID:Acute effects of exposure to 1 mg/m(3) of vaporized 2-ethyl-1-hexanol in humans. 2040 94

In this case study, hospital workers did suffer from symptoms related to the poor indoor air quality. To investigate reasons for symptoms MM40-survey and house inspection methods were performed. The study consisted of 49 operating rooms and 470 employees. MM-40 survey revealed that over 40% of the staff suffered from skin reactions, over 50% had upper respiratory tract symptoms and 25% suffered headaches. No reason for the staff's symptom could be found in the structural studies of workplaces. The mean air exchange rate of the rooms was 5.51/h. In total 61 materials and 49 indoor air samples were taken. The most frequently found compounds in the material samples were 2-ethyl-1-hexanol and aliphatic hydrocarbons. VOC emissions were high in some of the material samples and they presumably were the one reason for the workers' symptoms observed in some in of the rooms. However, indoor air VOC concentrations were low in most of the cases. According to the linear regression model emissions from flooring material couldn't explain the indoor air concentration of the VOCs. One reason for that was the high ventilation rates of the rooms, which presumably kept VOC levels in indoors low. In addition, VOC concentrations indoors were strongly related to the ongoing healthcare activities in the hospital.
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PMID:Indoor air-related symptoms and volatile organic compounds in materials and air in the hospital environment. 3047 94