Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In an observational study involving 10 non-hospital-affiliated physicians, 48 patients between 6 and 73 years of age with symptoms of acute tonsillitis were treated with either a liquid or tablet formulation of a herbal compound of Phytolacca, Guajacum, and Capsicum. More than half of the patients reported marked alleviation of the principal symptom, moderate or severe difficulty in swallowing, within the first 5 days of treatment. Comparable improvements occurred in other outcome measures, including earache, headache, and fatigue. No adverse side effects were reported.
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PMID:Treatment of acute tonsillitis with a fixed-combination herbal preparation. 1118 59

Capsaicin, the main ingredient responsible for the hot pungent taste of chilli peppers, is an alkaloid found in the Capsicum family. Capsaicin was traditionally used for muscular pain, headaches, to improve circulation and for its gastrointestinal protective effects. It was also commonly added to herbal formulations because it acts as a catalyst for other herbs and aids in their absorption. In addition, capsaicin and other capsaicinoid compounds showed strong evidence of having promising potential in the fight against many types of cancer. The mechanism of action of capsaicin has been extensively studied over the past decade. It has been established that capsaicin binds to the transient receptor potential vanilloid 1 receptor which was expressed predominantly by sensory neurons. And many analogues of capsaicin have been synthesized and evaluated for diverse bioactivities. In this review, we will attempt to summarize the biology and structure-activity relationship of capsaicinoids.
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PMID:Capsaicin and its analogues: structure-activity relationship study. 2362 37