Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Piracetam was applied to the treatment of 60 patients with the initial manifestations of brain blood supply failure and stage I encephalopathy associated with circulatory disorders. Echopulsography of the intracranial vessels and dopplerography of the extracranial vessels of the brain were employed, changes in lipid metabolism, rheological and coagulation properties of the blood were defined. Continuous use of piracetam per os was found to produce a number of beneficial therapeutic effects. Some patients suffering from encephalopathy associated with circulatory disorders showed headache enhancement after intake of 1.6 g of the drug, accompanied by a considerable increase of the amplitude of pulse fluctuations, prompting the reduction of the drug dose. Piracetam decreased the high vascular resistance and raised the lowered volume of pulse fluctuations. In all the patients examined, aggregation of formed elements of the blood returned to normal whereas the content of atherogenic lipids in blood serum significantly dropped.
 ...
PMID:[Piracetam and the indicators of cerebral hemodynamics, lipid metabolism and rheological properties of blood in the initial forms of cerebrovascular disorders]. 196 71

Piracetam was applied to the treatment of 60 patients with initial manifestations of brain circulation failure and stage I circulatory encephalopathy. The drug exerted a beneficial therapeutic effect by reducing high brain vascular resistance (both extra- and intracranial) and by increasing the lowered volume of pulse fluctuations. It made fibrinolytic blood activity and aggregation of formed elements of the blood return to normal. An appreciable antiatherogenic effect was discovered as well. It should be taken into consideration that in patients with a dramatic lowering of pulse fluctuations, the use of piracetam in a dose of 1.6 g/day may enhance headache. In such cases the dose should be reduced.
 ...
PMID:[Significance of subjective symptoms and diagnostic criteria in initial forms of cerebral circulation insufficiency]. 269 40