Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and two patients with either rheumatoid arthritis or osteo-arthrosis were treated for prolonged periods with diclophenac sodium (Voltaren; Geigy) to evaluate the efficacy and tolerability of the drug. Fifty-seven patients completed a trial of 12 months. A total of 70% showed an improvement in functional class, and 40% of the total had complete functional capacity by the end of the trial. The drug was well tolerated. The side-effects (heartburn, abdominal cramps, headache and dizziness) were mild and in most cases did not require cessation of treatment. In 9 patients the Coombs test became positive during the trial, but this did not require cessation of therapy.
 ...
PMID:A long-term study of diclophenac sodium in the treatment of rheumatoid arthritis and osteo-arthrosis. 35 28

In a double-blind crossover trial conducted on a multicentre basis, 109 patients with "classic" or "definite" rheumatoid arthritis were treated for two weeks with diclofenac sodium (Voltaren, 25 mg t.i.d.) and indomethacin (25 mg t.i.d). Both drugs led to a clear-cut decrease in morning stiffness, as well as to a significant improvement in pain at rest and on movement. In these respects no significant difference between the two-drugs was observed. As regards their effect on status of rheumatoid condition, however, a trend towards a significant improvement was discernible, in the investigator's opinion, only in response to diclofenac sodium. "Unwanted effects" were mentioned by 25 patients before the trial, by 31 during treatment with diclofenac sodium, and by 33 during treatment with indomethacin. While the patients were receiving indomethacin, five of them discontinued treatment on account of side effects (headache in three cases, headache and tiredness in one case, and an allergic skin reaction in one case) and one of them, who complained of headache, lowered the dosage; treatment with diclofenac sodium was discontinued because of side effects by only one patient, who had developed an allergic skin reaction.
 ...
PMID:Diclofenac sodium (Voltaren) and indomethacin in the ambulatory treatment of rheumatoid arthritis: a double-blind multicentre study. 35 46

We refer the results of an open non-comparative study aimed to evaluate the clinical efficacy of Diclofenac sodium in the treatment of Polyarticular Juvenile Chronic Arthritis. We decided to use this drug to investigate if it exerts also in younger patients the anti-inflammatory and analgesic effects known in adults. We treated 26 patients (14 girls and 12 boys) aged 2-16 years; the disease duration ranged between 3 months and 14 years. Treatment was started only if previous anti-inflammatory drugs had been considered ineffective after a prolonged use (3-12 months). None was on basic therapy. No wash-out period was used for ethical reasons. During the trial period other additional symptomatic or anti-inflammatory drugs were not used. Diclofenac sodium was given by tablets and/or suppositories at the mean daily dosage of 2.4 mg/kg (min. 0.3-max. 5, according to disease activity) for a period of 2-52 months. Diclofenac sodium was particularly effective on joint pain and morning stiffness but also on joint swelling, and functional capacity. We noticed a tendency of JRA to improve during the trial period. The drug was well tolerated; one patient stopped because of headache, another continued the treatment only per os because of intolerance of rectal administration.
 ...
PMID:[Clinical efficacy of sodium diclofenac in chronic juvenile polyarthritis]. 223 63

We examined 140 patients, aged from 23 to 47 years, with headache of tension type (HAT). Patients were stratified into two groups: HAT with trigger zones in pericranial muscles (HAT-1) and HAT without those (HAT-2). The study included the detection of pain threshold and pain tolerability in pericranial muscles using pressure algometer, quantitative assessment with the McGill Pain Questionnaire, evaluation of depression and anxiety. Loci of primary and secondary hyperalgesia, signs of anxiety disorder were observed in patients with HAT-1. Diclofenac sodium had a temporary effect and tizanidine had a stable positive effect. In patients with HAT-2, we found loci with signs of secondary hyperalgesia in pericranial muscles and symptoms of depression. There was no effect of diclofenac sodium, tizanidine had a subtle positive effect and venlafaxine exerted a good stable effect. In conclusion, there are different pathophysiological mechanisms of HAT with the presence of trigger zones in pericranial muscles and HAT without trigger zones.
 ...
PMID:[Clinical features of headache of tension type and principles of treatment]. 2118 2