Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lisuride is an ergot derivative which acts on serotonin and dopamine receptors at both peripheral and central levels. According to the central theory of headache, lisuride is an active prophylactic drug in adult headache sufferers. Because of its activity on dopamine receptors, a hypotensive action has been observed after acute and chronic administration of high doses of the drug in adults. An open trial on 45 migrainous children was carried out, to compare lisuride with pizotiphene treatment. Some 23 children were treated with lisuride and 22 with pizotiphene for 42 days. No statistically significant difference in therapeutic results between the two groups was found. Eight migrainous children were treated with a single oral dose of lisuride (0.0250 mg) and arterial blood pressure was measured before and after the drug. No significant change in either supine or orthostatic blood pressure was recorded in pre-drug and post-drug values. This study shows that lisuride is an effective and well-tolerated prophylactic drug in migrainous children.
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PMID:Lisuride as a migraine prophylactic in children: an open clinical trial. 667 14

Data on the treatment of 136 patients with essential headache using Lisuride are reported and discussed. The excellent tolerability of the drug and its considerable efficacy even after suspension of treatment are emphasised.
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PMID:[Analysis of the clinical experience with 136 patients with headache treated with lisuride]. 673 3

A macroprolactinoma recurred in a 25-year-old lady, who had initially presented with inability to conceive, secondary amenorrhea, galactorrhea and persistent headache. She was diagnosed as a patient of pituitary macroadenoma of 1.7 cm with elevated serum prolactin level. She was given Bromocriptine, which normalized her menstruation as well as the prolactin level followed by conception during treatment. Pregnancy remained uneventful till 27 weeks when she developed severe headache and total loss of vision from left eye and partial from right eye at 27 weeks. MRI showed enlargement of macroadenoma upto 2.5 cm with compression on optic chiasma. Transsphenoidal adenectomy was performed. After surgery visual field defect improved but plasma prolactin level remained elevated. She delivered vaginally at 39 weeks. Later, treatment with Bromocriptine (15 mg/day) failed to keep prolactin level normal and Lisuride hydrogen (0.8 mg/day) reduced the prolactin levels.
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PMID:Pregnancy with macroprolactinoma. 1903 98