Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nine patients suffered from intractable pain that was not relieved by analgesic medication. All had cancer of the stomach or pancreas. The coeliac plexus was approached from the back, two long Teflon catheters being directed onto the appropriate ganglia under x-ray control. When the catheters were correctly positioned, under continuous aspiration we administered via each catheter 25 ml of Xylocaine 0.5-0.8%. The successful and uneventful trial was followed with injection of an equal volume of 25 ml 50% alcohol through each catheter on the next day. In eight patients pain ceased completely while the ninth presented a 50% improvement. In the last five patients alcohol was injected 2 to 3 hours after the injection of the local anesthetic. We had a postspinal headache from accidental puncture of the dura mater, and a mild toxic reaction to Xylocaine. Also three patients presented hypotension after the Xylocaine was administered.
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PMID:[Infiltration block of the coeliac plexus using a plastic catheter]. 712 32

Often reasons of drug allergy are local anaesthetics. True allergic reactions are presented by the contact allergic dermatitis (the 4th type of allergic reaction, mediated by sensitized G-lymphocyte), while the reactions of instant type such as anaphylactic one can be observed rarely. So, if the drug allergy is clinically presented by contact allergic dermatitis, Novocain can be replaced by Lydocaine as they don't have similar chemical structure (the same antigenic features). However, in case of the anaphylactic (pseudo allergic) reactions, the main focus become the general mechanisms of local anaesthetic effects (instant toxic effect which are the same as Novocain, Lydocaine and all other local anaesthetics. This is why in case of anaphylactic reaction the substitution of Novocain by Lydocaine is not recommended. When conducting a skin test, if the drug which had caused an allergic reaction has not been identified, it is better to use the drug of the 2nd group. During the last 14 years the allergy department in the Central Clinic of TSMU, after negative skin tests (prick-test) on local anesthetics we conduct provocation tests on local anaesthetics which contain vasoconstrictive substance adrenaline (Ultracaine, Ubistezine, etc ). In 2008 this test was conducted with 1125 patients. Only in two cases the allergic reactions were observed in the form of edema and hyperemia of mucous membrane, headache and dizziness. In case of use of these drugs the system allergic reactions were not observed. So, the sublingual provocation test is a safe and reliable diagnostic test which prevents heavy system reactions, which correlates with data given by V. Pytski. Although measurable test, pre-medication, desensitization in most cases gives us the opportunity to prescribe the proper medicine, we should not forget about potential danger of reaction appearance and be ready to relief the symptoms rapidly. In addition, we should not forget about juridical, forensic aspects and, in particular, medical card must include informational agreement, precisely documented necessity of medical procedure, and respective consultations of specialists.
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PMID:[Main principles of pathogenesis, diagnostics and prevention of drug allergy caused by local anaesthetics]. 1935 25