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 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A survey of occupational physicians of the Food Industry Medical Officers Group was undertaken to establish details of medical kits supplied by their organizations to business travellers. The most common approach was an in-house medical kit with instructions emphasizing self treatment of the common ailments of travellers such as motion sickness, sleeplessness, diarrhoea, indigestion and headaches. The majority of kits included a small supply of needles, syringes, IV cannulae etc either in a commercial 'Aids Kit' or as inhouse supplies. Antimalarials were provided either as a standard kit item or as required. About half provided antibiotics for the self treatment of infections. Very few provided a telephone number for use in the event of medical emergencies. A standard medical kit specification is proposed.
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PMID:Medical kits for business travellers. 221 91

The article describes the health situation in relation to demographic and social class variables in a sample of 1,671 schoolchildren aged 11, 13 and 15 years in Denmark. The proportions assessing their health as excellent, good, fair, or poor were 47%, 39%, 13%, and 1%, respectively. 22% reported daily symptoms and 74% weekly symptoms (20% one symptom a week, 54% two or more symptoms). During one week, 50% suffered from bad moods, 37% insomnia, 30% depression, 26% headaches, 22% nervousness, 19% back pain, 14% abdominal pain, and 12% vertigo. 37% had used medical drugs during the last month, most frequently for headaches (25%), colds (11%), coughs (9%) and abdominal pain (8%). Girls showed poorer self-assessed health than boys, more symptoms and more use of medication. The youngest pupils had the most frequent symptoms and the oldest least. There were no health differences when place of residence or family composition were considered, but there were clear social class differences. Pupils from the lowest social class and pupils whose parents were not included in the social class classification (e.g. disability pensioners) had the poorest self-assessed health, the most frequent symptoms and the highest use of medication.
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PMID:[Social inequalities in child health status]. 221 29

We compared 40 outpatients with "pure" generalized anxiety disorder (GAD) with 152 panic disordered patients with varying degrees of phobic avoidance, and 241 primary major depressives with single and recurrent episodic patterns. Despite sociodemographic and symptomatologic overlaps with these comparison groups, GAD emerged as a relatively distinct disorder, characterized by chronic low-grade symptomatology with observed anxiety at interview, as well as nausea, headache, tension, and insomnia. These anxious "traits," which appear to be part of the habitual self of the patient, are subject to fluctuation over time, and may form the temperamental substrate or precursor of panic and other anxiety and depressive disorders.
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PMID:Delimitation of generalized anxiety disorder: clinical comparisons with panic and major depressive disorders. 222 99

We administered 20 ml of Yomeishu (YMS) twice a day before meals for 12 weeks to 50 post-operative patients in gynecology and then inquired into their subjective 20 symptoms (sense of fatigue, insomnia, headache and heavy headedness, appetite, stomach-ache, abdominal inflation, vertigo, lumbago, etc.) The YMS group showed a significant improvement on 14 items compared with the control group. On the whole, a great improvement was observed in the YMS group with serious subjective symptoms as well, and there were significant differences for general condition, sense of fatigue, and coldness in extremities.
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PMID:Effects of a medicinal herbal liqueur, "yomeishu", on post-operative gynecological patients. 223 15

A therapeutic committee was established in Toulouse Regional University Hospital in order to prescribe zidovudine in patients suffering from AIDS. Using an informatic card, the side effects were evaluated in the 125 patients treated by Zidovudine since the creation of the Committee (from July 1987 to January 1989). Zidovudine was prescribed from May 1987 to June 1988 at the total dose of 1,200 mg daily from June 1988 at 900 mg daily. The most frequent side effects were hematologic: zidovudine used alone (or associated with non hematotoxic drugs) elicited in 21.2% of patients a neutropenia (defined as a number of neutrophils less than 1,000/mm3), in 2.4% anaemia (haemoglobin less than or equal to 9 g/100 ml) and in 4.8% neutropenia associated with anaemia. When zidovudine was administered with hematotoxic drugs, neutropenia, anaemia or the association of both were observed in 12.0%, 3.2% and 2.4% of patients respectively. These hematologic side effects were always regressive after drug cessation. However, it is important to underline the low incidence of hematological side effects on red cells of zidovudine in the present study. This result is unexpected. The other side effects of Zidovudine (used alone) did not led to modification in drug treatment: gastrointestinal disturbances (30.4%), headaches (16.8%), insomnia (13.6%), somnolence (6.4%).... These side effects appeared during the four first months and decreased with the continuation of drug treatment. Their imputation was difficult to define and differentiate to evolution of the disease.
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PMID:[Evaluation of the pharmacovigilance follow-up of zidovudine]. 226 33

This is a study of the prevalence of depressive disorder among elderly Chinese people living in the community in Singapore. A total of 612 subjects were assessed using the Geriatric Mental State Schedule. The prevalence of depressive disorder was found to be 4.6%. The rate was higher among Chinese people between 65-74 years than among those 75 years and above, and also higher for females than males. The majority of cases were mild and the common symptoms were feelings of sadness, insomnia, headache, pessimism and tension. There was no depressive psychosis or mania.
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PMID:Depressive disorder in elderly Chinese people. 234 65

It is evident that couvade syndrome exists in the industrialized culture. However, there are questions about the occurrence of couvade given the large range of reported incidence. Clinton found no difference in the occurrence of symptoms between expectant fathers and nonexpectant men throughout the three trimesters of pregnancy. Differences were noted, however, in the types and perceived seriousness of symptoms between these men, with expectant fathers reporting more colds, unintentional weight gain, insomnia, and restlessness. Significant differences in health deviation were reported by the new fathers during the immediate postpartum period. These new fathers experienced fatigue, emotional and cognitive disturbances, and headaches. Strickland's work did not provide comparative estimates of the incidence of couvade syndrome. The focus of this study was to explore the nature of pregnancy-related symptoms among expectant fathers. These expectant fathers reported key symptoms during the second trimester of pregnancy with increasing occurrence during the last trimester of pregnancy. Expectant fathers most likely to experience couvade were anxious, black, working class men experiencing an unplanned pregnancy. Anxiety, suppression of hostility, and identification with the pregnant partner were explored as predictors of the occurrence of couvade syndrome. Anxiety is likely to occur in expectant fathers because of financial concerns and changes in relationships and roles. Feelings of protectiveness toward the partner and fetus/infant also can be anxiety producing for the expectant father. The developmental tasks described by Duvall and Penticuff were predicated on the transitional nature of becoming a parent. Each task depicts the inherent change in both structure and function of the male's family role which is influenced by society and the family unit. May proposed that expectant fathers have unique styles that predict the degree of involvement with the partner and the pregnancy. Phases of father involvement, described by May, and the father's laboring for relevance, described by Jordan, are conceptually consistent with the developmental tasks identified by Duvall. Each phase or subprocess is sequential, marked by intrapersonal and interpersonal characteristics. Movement through these tasks, phases, or subprocesses is dependent upon accepting the reality of the pregnancy, cultural norms, and society's expectations of fathers. Herzog identified degrees of involvement among fathers whose partners delivered prematurely. In this retrospective inquiry, fathers with a high degree of involvement were more likely to experience symptoms of couvade syndrome than were fathers who were less involved. All fathers in the study, regardless of the involvement, reported being fearful of the unknown outcome and experiencing grief over the preterm delivery.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Expectant fathers' response to pregnancy: review of literature and implications for research in high-risk pregnancy. 239 46

Aminoglutethimide (AG) was administered as palliative therapy in 112 patients with metastatic breast cancer. In 36 patients, the dose level was 1000 mg/day; 76 patients received a dose level of 500 mg/day. Patients with brain or liver metastasis were excluded, as were patients with tumors determined to be negative for estrogen receptors. Objective regression was observed in 35 (31%) patients, with the duration of response ranging from 4 to 36 + months (mean, 12 months; median, 10 months). Response was observed in 11 of 31 (35%) patients with soft tissue metastasis; 16/59 (27%) patients with osseous metastasis; and 8 of 22 (36%) having visceral metastasis. In 93 patients with positive estrogen receptor (ER), 33 responded (35%), whereas in 19 patients with unknown ER status, two responded (11%). Response to previous treatment with tamoxifen (TAM) had occurred in 31 patients; of these, response to AG was noted in 11 (35%). Of 24 patients failing to respond to prior treatment with tamoxifen, four (17%) responded to subsequent therapy with AG. Thirteen patients had previously received combination chemotherapy, and response to AG was noted in two (15%). The side effects observed in this study included skin rash in ten patients, fever in eight, somnolence in three, weakness and dizziness in one, headache in one, insomnia in one, dyspnea in one, and ataxia in one. Treatment had to be discontinued in eight patients, due to the severity of the side effects. As expected, patients receiving AG at the lower dose level of 500 mg/day experienced fewer and less severe side effects than those treated with the higher dose. The response rate in the 1000 mg/day group was 10/36 (28%) and in the 500 mg/day group, it was 25/76 (33%). The lower dosage was better tolerated without apparent compromise in therapeutic efficacy.
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PMID:Aminoglutethimide in patients with metastatic breast cancer. 246 35

A multicenter, randomized, double-blind, comparative study was conducted in 274 patients with mild to moderate hypertension to assess the impact of nitrendipine and propranolol on quality of life. After placebo baseline, 136 patients were given nitrendipine (5-20 mg b.i.d.) and 138 were given propranolol (40-120 mg b.i.d.). Quality of life was evaluated at baseline, weeks 6-10, and weeks 14-18 of the maintenance period. At weeks 6-10, the nitrendipine group became significantly more vigorous (p less than 0.01) and less fatigued (p less than 0.05) than the propranolol group. Propranolol subjects noted decreased problems of trembling hands (p less than 0.01) and alcohol use (p less than 0.05) than the nitrendipine subjects. No other significant differences between groups in mood states, troublesome conditions (insomnia, headaches, and loss of appetite), or sexual satisfaction were noted at this visit, and patient willingness to continue study medication was marginally significantly higher (p less than 0.1) in the nitrendipine group than in the propranolol group. At weeks 14-18, the propranolol subjects perceived significantly decreased problems with the "felt worried, tense, and drank alcohol to cope" factor (p less than 0.05); however, there were no differences between groups at this visit for Profile of Mood States (POMS) scores, sex life variables, or medication preference. Based on within-group analysis, the propranolol group perceived a reduction in partner sexual satisfaction (p less than 0.05). Overall, nitrendipine seemed to be better tolerated than propranolol.
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PMID:Comparison of quality of life on nitrendipine and propranolol. 246 71

From may 1986 to July 1988 ten patients have been treated by interstitial implantation of radioactive isotopes using Yttrium 90 colloidal solution (9 cases) and Aurum 198 grains (1 case). There were 7 cystic out of 8 craniopharyngiomas, one malignant pituitary adenoma and one hemispheric Astrocytoma grade III-IV. In all but one patient the tumors were recurrent after one or more reductive or palliative operations. To external radiation undervent preoperatively two cases (one craniopharyngioma and one pituitary adenoma). Target volume was established by CT data and X-ray studies after stereotaxic injection of contrast medium (one case). Doses for intracystic irradiation were calculated using the Backlund's formula. The lowest activity was calculated to be 3.84 mCi, and the highest 12.9 mCi (m 6.8 mCi or 252 MBq). The delivered activity was 100-200 Gy of Y90 (m 140 Gy). The activity of Au198 was determined using the producers dosimetric tables. The radionuclide implantation was performed by stereotaxic techniques with Leksell's system in 5 patients. In 5 patients the surgical procedures were open: 3 osteoplastic supratentorial and 2 craniectomies for direct instillation of Y90 into the craniopharyngiomatous cavities spread to posterior fossa. Early short lasting side effects of endocavitary irradiation were observed in 5 patients (headache and somnolence; adynamy, pseudobulbar symptoms and rigor; insomnia and agressiveness; lack of orientation and increased mental irritability). The longest follow up was 26 months. The clinical response to intracystic instillation of Y90 was very favorable in 8 cases: 7 craniopharyngiomas and one pituitary adenoma. A satisfactory anatomical result with diminution or retraction of cystic cavities was evident in all cases. The more pronounced achievement of intracystic irradiation therapy in our series were the effects on stabilization or recuperation of vision and on improvement of visual field finding. The recovery of endocrine insufficiency was also noted. Two patients died: the 3-year old child, one year after implantation of Au198 grains in a huge calcified craniopharyngioma, and a woman, 67 old, twelve days after Y90 instillation to a hemispheric glioma grade III-IV.
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PMID:[Implantation of radioactive isotopes in intracranial tumors]. 248 66


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