Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty consecutive patients with chronic renal failure (CRF) and 20 control patients received subarachnoid anaesthesia with 3 ml of 0.75% bupivacaine plain for surgery in the lower abdomen. Sensory analgesia (onset) developed significantly more rapidly in the CRF patients: maximum segmental level of pin-prick analgesia was reached in an average of 21 min in the CRF patients and in 35 min in the control patients. An observed tendency to acidosis and a possible reduced intrathecal space in the uraemic patients may account for the more rapid blockade. The mean spread of the sensory block in CRF patients (T4) was two segments higher than that in the control patients, but because of marked inter-individual variation this difference cannot be considered clinically important. Three CRF patients and two control patients had insufficient analgesia for surgery. In the CRF patients, both sensory and motor blockades were of shorter duration than in the control patients. The incidence of complaints of nausea and backache was similar in the groups. One control patient had a headache.
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PMID:Subarachnoid anaesthesia with 0.75% bupivacaine in patients with chronic renal failure. 370 97

Saddle blockade with pethidine hydrochloride was performed in 111 patients undergoing short surgical operations on the perineum. A dose of 5% pethidine 0.5 mg kg-1 was injected to the subarachnoid space at L4-5 or L5-S1 with the patient in the sitting position. Sensory blockade was achieved in 5.28 +/- 1.43 min. This extended to the sacrococcygeal area, perineum, buttocks and posterior surface of thighs, and was followed 1-2 min later by motor blockade. During the operation the patients were stable haemodynamically and no respiratory depression was recorded. Sensory blockade lasted for 141 +/- 26.06 min and was followed by postoperative analgesia, the mean duration of which was 301 +/- 98.38 min. Postoperative neurological complications were recorded in three patients (2.7%): headache alone in one, headache associated with backache in one, and leg weakness, backache, nuchal rigidity and photophobia in another. Seven patients (6.3%) complained of itching, five patients (4.5%) of nausea and vomiting and two (1.8%) developed urinary retention.
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PMID:Saddle block with pethidine for perineal operations. 375 47

Experiences with intrathecal morphine analgesia in 36 patients undergoing Wertheim-Held hysterectomy are reported. Postoperative painrelief, bloodgas-parameters (pO2, pCO2, pH, SBE, SAT), analgetica demand, side-effects are compared with 23 patients of a control group. 95% of patients with intrathecal morphine analgesia were postoperatively without pain for at least 24 hours. The postoperative demand of analgetic drugs could be reduced to less than 50% in the first 48 postoperative hours. Besides not significant decreasing of the pH-value no changing of the bloodgases was observed. The incidence of nausea, vomiting and headache were not increased. Considering the not in all cases avoidable development of a respiration insufficiency even after a little dosis of morphine this method seems to be a suitable treatment of postoperative pain which enables the early mobilisation of the patients.
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PMID:[Intrathecal morphine administration in pain therapy following extensive gynecologic operations. Clinical study]. 383 60

Four postpartum patients with complaints of headache and neck pain were examined. All had received epidural analgesia and had a long second stage associated with prolonged pushing. Many similarities to postdural puncture headache were noted. The headache started the day after delivery and involved the occipital region primarily, along with the neck and shoulder girdle areas. However, the pain did not change with positional changes and was associated with marked tenderness of muscles at specific anatomic points. A diagnosis of cervical myofascial pain was made. All patients responded quickly to physical therapy. The authors suggest that many patients initially considered to have postdural puncture headache may actually have postpartum cervical myofascial pain.
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PMID:Postpartum cervical myofascial pain syndrome: review of four patients. 397 77

Seven patients are described in whom a prophylactic blood patch was instituted within 15 min of accidental dural puncture. Five of the patients received extradural anaesthesia before the blood patch, and one after the blood patch had been performed. In three of these patients further "top-up" doses of local anaesthetic were performed through the extradural catheter. The quality of analgesia obtained was satisfactory. No symptoms of spinal headache occurred in any of the patients.
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PMID:Extradural blood patch--why delay? 399 90

Endogenous hyperprolactinaemia induced by anterior pituitary transplantation under the kidney capsule has been found to reduce the behavioural responsiveness to electrical footshock and to increase morphine-induced analgesia. The apparent analgesic effect of prolactin has been related to the stimulation of nigro-striatal dopaminergic transmission, as suggested by the increase in striatal dopamine turnover observed in hyperprolactinaemic rats. It seems likely that central opiate system is involved in the behavioural effects of prolactin. Thus, naloxone prevents the effects of hyperprolactinaemia on footshock responsiveness and heroin self-administration is decreased in hyperprolactinaemic rats.
Cephalalgia 1983 Aug
PMID:Role of prolactin-opiate interactions in the central regulation of pain threshold. 631 24

A study of the side effects of epidural anesthesia for painless delivery in 100 patients showed that 90% of the post partum patients were very satisfied with the analgesia and did not consider symptoms post partum to be very debilitating and did not blame the epidural anesthesia for the symptoms. Severe pain in the occiput and the cervical spine occurred in only two cases. In one case, the cerebro-spinal fluid was punctured. Headaches following epidural anesthesia are described as a great disadvantage of this method of obstetric analgesia. However, the headaches were no more common in the group with epidural anesthesia than in the compare group. No correlation was found with puncture of the dura which is suspected in the literature. Retention of urine was not found to be correlated to the epidural anesthesia. Uniformity of the responses by the maternity patients were striking especially if one considered that the social condition and the psychic condition of the individual woman such as attitude to delivery, presence of the husband at delivery, and other factors were not evaluated.
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PMID:[Headache following epidural anesthesia]. 637 80

Epidural buprenorphine was investigated as a postoperative analgesic in a randomized double-blind study of 158 patients given epidural analgesia with mepivacaine or bupivacaine for orthopedic surgery of the lower extremity. At the end of surgery, patients were given either 0.15 mg of epidural buprenorphine (n = 38), 0.3 mg (n = 37) in 15-ml saline, or no further epidural injections (n = 47, control group) after 2% mepivacaine for intraoperative anesthesia. A fourth group (n = 36) received 0.3 mg of buprenorphine in 15-ml saline, after the intraoperative use of 0.5% bupivacaine. The patients rated postoperative pain. The need for additional analgesics as well as side effects were recorded. Analgesia after 0.15 mg buprenorphine was superior to that after no reinjection for 6 hr after surgery (P less than 0.05). Buprenorphine (0.3 mg) was superior both to no reinjection and to 0.15 mg of buprenorphine until the twelfth hour (P less than 0.05). Analgesia after bupivacaine followed by 0.3 mg of buprenorphine was not significantly different than analgesia seen after mepivacaine followed by 0.3 mg of buprenorphine. There was an increase of PaCO2 of 2-5 mm Hg between 1.5-3.5 hr after 0.3 mg of buprenorphine without any evidence for late respiratory depression. Other side effects, e.g., disturbances of micturition, pruritus, nausea, vomiting, fatigue, and headache, were comparably common in all groups. The epidural administration of 0.3 mg buprenorphine may be recommended for postoperative analgesia following orthopedic surgery of the lower extremity.
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PMID:Epidural buprenorphine--a double-blind study of postoperative analgesia and side effects. 637 65

In this factorial study, 148 outpatients with pain after oral surgery were randomly assigned, on a double-blind basis, a single oral dose of acetaminophen 650 mg, phenyltoloxamine 60 mg, a combination of acetaminophen 650 mg with phenyltoloxamine 60 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medication. Measures of total and peak analgesia were derived from these subjective reports. The acetaminophen effect was significant for every measure of total and peak analgesia. The phenyltoloxamine effect was not significant for any measure of analgesia. Although efficacy was lower for the acetaminophen-phenyltoloxamine combination than for acetaminophen alone, for every variable, the contrast for interaction was not statistically significant. The results of this study differ from those of previous studies in patients with headache and musculoskeletal pain. All adverse effects were transitory and consistent with the known pharmacologic profiles of the study medications or the backup analgesic.
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PMID:Analgesic effect of acetaminophen, phenyltoloxamine and their combination in postoperative oral surgery pain. 648 39

The indications for rachianesthesia have been considerably widened in recent years in our department. The technique is particularly suitable for urological cases, and two thousand patients have been anesthetized in this way over the past four years, with a zero mortality rate. Complications were exceptional at operation, and postoperative complications consisted mainly of headaches. The incidence of these cases can be reduced by using very fine needles, and the are more frequent in the young than in older patients. There are few absolute contra-indications, and they consist in coagulation problems, suppurative lesions of the lumbar region, evolutive medullar affections and a case history of Pott's disease. The advantage of rachidial over peridural anesthesia is the greater rapidity of the execution and installation. For this reason it seems to us the method of choice for relatively short and repetitive operations, and operations on elderly patients (it is preferable to avoid this method in young patients, because of the risk of headaches). We reserve peridural anesthesia more particularly for long operations requiring postoperative analgesia.
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PMID:[Spinal anesthesia in urology. Apropos of 2200 cases]. 652 3


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